RAC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048870Biological processcell motility
GO_0006954Biological processinflammatory response
GO_0030041Biological processactin filament polymerization
GO_0001764Biological processneuron migration
GO_0097178Biological processruffle assembly
GO_0030036Biological processactin cytoskeleton organization
GO_0030334Biological processregulation of cell migration
GO_1900026Biological processpositive regulation of substrate adhesion-dependent cell spreading
GO_0043652Biological processengulfment of apoptotic cell
GO_0060326Biological processcell chemotaxis
GO_1902622Biological processregulation of neutrophil migration
GO_0010811Biological processpositive regulation of cell-substrate adhesion
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0007155Biological processcell adhesion
GO_0003376Biological processsphingosine-1-phosphate receptor signaling pathway
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0009653Biological processanatomical structure morphogenesis
GO_0048012Biological processhepatocyte growth factor receptor signaling pathway
GO_0010310Biological processregulation of hydrogen peroxide metabolic process
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0016601Biological processRac protein signal transduction
GO_0051492Biological processregulation of stress fiber assembly
GO_0051894Biological processpositive regulation of focal adhesion assembly
GO_0060263Biological processregulation of respiratory burst
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0048261Biological processnegative regulation of receptor-mediated endocytosis
GO_0009611Biological processresponse to wounding
GO_0016477Biological processcell migration
GO_0045730Biological processrespiratory burst
GO_0031529Biological processruffle organization
GO_0045428Biological processregulation of nitric oxide biosynthetic process
GO_0007160Biological processcell-matrix adhesion
GO_0030032Biological processlamellipodium assembly
GO_0010595Biological processpositive regulation of endothelial cell migration
GO_0032707Biological processnegative regulation of interleukin-23 production
GO_0010592Biological processpositive regulation of lamellipodium assembly
GO_0030031Biological processcell projection assembly
GO_0010764Biological processnegative regulation of fibroblast migration
GO_0031116Biological processpositive regulation of microtubule polymerization
GO_0030865Biological processcortical cytoskeleton organization
GO_0035556Biological processintracellular signal transduction
GO_0051668Biological processlocalization within membrane
GO_0007264Biological processsmall GTPase-mediated signal transduction
GO_0007015Biological processactin filament organization
GO_0008045Biological processmotor neuron axon guidance
GO_0008360Biological processregulation of cell shape
GO_0060071Biological processWnt signaling pathway, planar cell polarity pathway
GO_0008361Biological processregulation of cell size
GO_0071526Biological processsemaphorin-plexin signaling pathway
GO_0035025Biological processpositive regulation of Rho protein signal transduction
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0010591Biological processregulation of lamellipodium assembly
GO_0098978Cellular componentglutamatergic synapse
GO_0005856Cellular componentcytoskeleton
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0043020Cellular componentNADPH oxidase complex
GO_0098794Cellular componentpostsynapse
GO_0005802Cellular componenttrans-Golgi network
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0005634Cellular componentnucleus
GO_0070062Cellular componentextracellular exosome
GO_0055038Cellular componentrecycling endosome membrane
GO_0030027Cellular componentlamellipodium
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0005884Cellular componentactin filament
GO_0005737Cellular componentcytoplasm
GO_0032587Cellular componentruffle membrane
GO_0030667Cellular componentsecretory granule membrane
GO_0043197Cellular componentdendritic spine
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0005925Cellular componentfocal adhesion
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0042470Cellular componentmelanosome
GO_0051022Molecular functionRho GDP-dissociation inhibitor binding
GO_0003924Molecular functionGTPase activity
GO_0019899Molecular functionenzyme binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0031996Molecular functionthioesterase binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0003925Molecular functionG protein activity

IV. Literature review

[source]
Gene nameRAC1
Protein nameRas-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (p21-Rac1)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Rac family small GTPase 1
Ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1)
pancreatic ribonuclease (EC 4.6.1.18)
SynonymsMIG5
tcag7.839
TC25
hCG_14926
DescriptionFUNCTION: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles . Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity . In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts . In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In neurons, is involved in dendritic spine formation and synaptic plasticity (By similarity). In hippocampal neurons, involved in spine morphogenesis and synapse formation, through local activation at synapses by guanine nucleotide exchange factors (GEFs), such as ARHGEF6/ARHGEF7/PIX . In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in PAK1 activation and eventually F-actin stabilization (By similarity). .; FUNCTION: [Isoform B]: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins . It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction . .

AccessionsENST00000704003.1
ENST00000356142.4 [P63000-2]
P63000
ENST00000348035.9 [P63000-1]
A4D2P0
A0A994J4S4
ENST00000704002.1
A0A994J6T1
W0UV93
A4D2P1
A4D2P2