CD47 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050870Biological processpositive regulation of T cell activation
GO_0001525Biological processangiogenesis
GO_0032680Biological processregulation of tumor necrosis factor production
GO_0050766Biological processpositive regulation of phagocytosis
GO_0032655Biological processregulation of interleukin-12 production
GO_0006954Biological processinflammatory response
GO_0032653Biological processregulation of interleukin-10 production
GO_0032649Biological processregulation of type II interferon production
GO_0045428Biological processregulation of nitric oxide biosynthetic process
GO_0051496Biological processpositive regulation of stress fiber assembly
GO_0060368Biological processregulation of Fc receptor mediated stimulatory signaling pathway
GO_0071347Biological processcellular response to interleukin-1
GO_0034113Biological processheterotypic cell-cell adhesion
GO_2000439Biological processpositive regulation of monocyte extravasation
GO_0050765Biological processnegative regulation of phagocytosis
GO_0007229Biological processintegrin-mediated signaling pathway
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0050729Biological processpositive regulation of inflammatory response
GO_0032675Biological processregulation of interleukin-6 production
GO_0071349Biological processcellular response to interleukin-12
GO_0016477Biological processcell migration
GO_1904669Biological processATP export
GO_0022409Biological processpositive regulation of cell-cell adhesion
GO_0071346Biological processcellular response to type II interferon
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0070821Cellular componenttertiary granule membrane
GO_0070053Molecular functionthrombospondin receptor activity
GO_0086080Molecular functionprotein binding involved in heterotypic cell-cell adhesion
GO_0098632Molecular functioncell-cell adhesion mediator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCD47
Protein nameLeukocyte surface antigen CD47 (Integrin-associated protein)
CD47 molecule
Leukocyte surface antigen CD47 (Antigenic surface determinant protein OA3) (Integrin-associated protein) (IAP) (Protein MER6) (CD antigen CD47)
SynonymsMER6
DescriptionFUNCTION: Adhesive protein that mediates cell-to-cell interactions . Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins . Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation . Plays a role in modulating pulmonary endothelin EDN1 signaling . Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells . Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation . Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging . In response to THBS1, negatively modulates wound healing (By similarity). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction . May prevent premature elimination of red blood cells (By similarity). .

AccessionsENST00000355354.13 [Q08722-3]
ENST00000398258.7
Q08722
A0A2R8Y484
A0A0A1TSG4
ENST00000644850.1
ENST00000517766.5
H7BYS8
ENST00000361309.6 [Q08722-1]
H0YC40