TNFAIP6 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TNFAIP6 at tissue level.

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0007165Biological processsignal transduction
GO_0007155Biological processcell adhesion
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0007267Biological processcell-cell signaling
GO_1905590Biological processfibronectin fibril organization
GO_0030212Biological processhyaluronan metabolic process
GO_1903911Biological processpositive regulation of receptor clustering
GO_0050728Biological processnegative regulation of inflammatory response
GO_0030335Biological processpositive regulation of cell migration
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0001550Biological processovarian cumulus expansion
GO_0090024Biological processnegative regulation of neutrophil chemotaxis
GO_0045671Biological processnegative regulation of osteoclast differentiation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_1904724Cellular componenttertiary granule lumen
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0106435Molecular functioncarboxylesterase activity
GO_0001968Molecular functionfibronectin binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0005540Molecular functionhyaluronic acid binding

IV. Literature review

[source]
Gene nameTNFAIP6
Protein nameTumor necrosis factor-inducible gene 6 protein (EC 3.1.1.-) (Hyaluronate-binding protein) (TNF-stimulated gene 6 protein) (TSG-6) (Tumor necrosis factor alpha-induced protein 6) (TNF alpha-induced protein 6)
SynonymsTSG6
DescriptionFUNCTION: Major regulator of extracellular matrix organization during tissue remodeling . Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin . Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization . Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling . Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation . In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium . Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts . Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation . .

AccessionsP98066
ENST00000243347.5