Name | Number of supported studies | Average coverage | |
---|---|---|---|
classical monocyte | 10 studies | 24% ± 9% | |
endothelial cell | 6 studies | 23% ± 7% | |
glutamatergic neuron | 6 studies | 33% ± 10% | |
non-classical monocyte | 5 studies | 27% ± 10% | |
pancreatic A cell | 4 studies | 33% ± 8% | |
neuron | 4 studies | 29% ± 10% | |
epithelial cell | 4 studies | 31% ± 9% | |
basal cell | 4 studies | 26% ± 10% | |
type B pancreatic cell | 3 studies | 36% ± 4% | |
conventional dendritic cell | 3 studies | 29% ± 11% | |
fibroblast | 3 studies | 21% ± 4% | |
ciliated cell | 3 studies | 20% ± 2% | |
macrophage | 3 studies | 23% ± 2% | |
dendritic cell | 3 studies | 32% ± 10% | |
abnormal cell | 3 studies | 20% ± 4% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 5% | |
GABAergic neuron | 3 studies | 27% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 100% | 5654.61 | 89 / 89 | 100% | 51.09 | 901 / 901 |
liver | 100% | 8499.98 | 226 / 226 | 100% | 64.64 | 406 / 406 |
ovary | 100% | 3507.96 | 180 / 180 | 100% | 25.74 | 430 / 430 |
pancreas | 100% | 4193.05 | 328 / 328 | 100% | 45.95 | 178 / 178 |
prostate | 100% | 5233.72 | 245 / 245 | 100% | 68.23 | 502 / 502 |
esophagus | 100% | 6737.89 | 1444 / 1445 | 100% | 41.47 | 183 / 183 |
brain | 100% | 10669.53 | 2639 / 2642 | 100% | 76.77 | 705 / 705 |
skin | 100% | 7527.88 | 1809 / 1809 | 100% | 54.92 | 471 / 472 |
uterus | 100% | 3528.05 | 170 / 170 | 100% | 39.17 | 458 / 459 |
stomach | 100% | 3678.75 | 358 / 359 | 100% | 37.20 | 286 / 286 |
adrenal gland | 100% | 5127.45 | 258 / 258 | 100% | 46.26 | 229 / 230 |
thymus | 100% | 4129.52 | 651 / 653 | 100% | 51.87 | 604 / 605 |
intestine | 100% | 3860.28 | 966 / 966 | 99% | 39.08 | 524 / 527 |
bladder | 100% | 4950.00 | 21 / 21 | 99% | 44.95 | 501 / 504 |
lung | 99% | 3829.71 | 575 / 578 | 100% | 35.78 | 1152 / 1155 |
breast | 100% | 3802.75 | 459 / 459 | 99% | 40.97 | 1107 / 1118 |
eye | 0% | 0 | 0 / 0 | 100% | 78.78 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 36.83 | 29 / 29 |
muscle | 100% | 5742.66 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 4155.45 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 44.31 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 22.91 | 1 / 1 |
adipose | 100% | 3768.83 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4449.05 | 1333 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 97% | 3584.62 | 903 / 929 | 0% | 0 | 0 / 0 |
heart | 95% | 2862.41 | 815 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006954 | Biological process | inflammatory response |
GO_0030855 | Biological process | epithelial cell differentiation |
GO_0045087 | Biological process | innate immune response |
GO_0007165 | Biological process | signal transduction |
GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
GO_0070498 | Biological process | interleukin-1-mediated signaling pathway |
GO_0045321 | Biological process | leukocyte activation |
GO_0033235 | Biological process | positive regulation of protein sumoylation |
GO_0006914 | Biological process | autophagy |
GO_0016310 | Biological process | phosphorylation |
GO_0036010 | Biological process | protein localization to endosome |
GO_0035578 | Cellular component | azurophil granule lumen |
GO_0005576 | Cellular component | extracellular region |
GO_0035580 | Cellular component | specific granule lumen |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005769 | Cellular component | early endosome |
GO_0019897 | Cellular component | extrinsic component of plasma membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0032991 | Cellular component | protein-containing complex |
GO_0016604 | Cellular component | nuclear body |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0019900 | Molecular function | kinase binding |
GO_0035325 | Molecular function | Toll-like receptor binding |
GO_0031625 | Molecular function | ubiquitin protein ligase binding |
GO_0032183 | Molecular function | SUMO binding |
GO_0005150 | Molecular function | interleukin-1, type I receptor binding |
GO_0005515 | Molecular function | protein binding |
GO_0043130 | Molecular function | ubiquitin binding |
GO_0031624 | Molecular function | ubiquitin conjugating enzyme binding |
Gene name | TOLLIP |
Protein name | Toll-interacting protein Toll interacting protein TOLLIP protein (Toll interacting protein) (cDNA, FLJ96670, Homo sapiens toll interacting protein (TOLLIP), mRNA) |
Synonyms | hCG_40380 |
Description | FUNCTION: Component of the signaling pathway of IL-1 and Toll-like receptors . Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex . Inhibits IRAK1 phosphorylation and kinase activity . Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates . The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates . In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes . Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) . . |
Accessions | ENST00000317204.11 [Q9H0E2-1] ENST00000263646.11 ENST00000527938.5 ENST00000707519.1 [Q9H0E2-1] ENST00000530506.5 ENST00000707520.1 [Q9H0E2-2] Q6FIE9 ENST00000530541.1 F2Z2Y8 E9PQ25 Q9H0E2 E9PNS3 ENST00000525159.5 ENST00000527886.5 [Q9H0E2-2] E7EN89 E9PP67 |