TOLLIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0030855Biological processepithelial cell differentiation
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0045321Biological processleukocyte activation
GO_0033235Biological processpositive regulation of protein sumoylation
GO_0006914Biological processautophagy
GO_0016310Biological processphosphorylation
GO_0036010Biological processprotein localization to endosome
GO_0035578Cellular componentazurophil granule lumen
GO_0005576Cellular componentextracellular region
GO_0035580Cellular componentspecific granule lumen
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0019897Cellular componentextrinsic component of plasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0060090Molecular functionmolecular adaptor activity
GO_0019900Molecular functionkinase binding
GO_0035325Molecular functionToll-like receptor binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0032183Molecular functionSUMO binding
GO_0005150Molecular functioninterleukin-1, type I receptor binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding
GO_0031624Molecular functionubiquitin conjugating enzyme binding

IV. Literature review

[source]
Gene nameTOLLIP
Protein nameToll-interacting protein
Toll interacting protein
TOLLIP protein (Toll interacting protein) (cDNA, FLJ96670, Homo sapiens toll interacting protein (TOLLIP), mRNA)
SynonymshCG_40380
DescriptionFUNCTION: Component of the signaling pathway of IL-1 and Toll-like receptors . Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex . Inhibits IRAK1 phosphorylation and kinase activity . Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates . The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates . In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes . Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) . .

AccessionsENST00000317204.11 [Q9H0E2-1]
ENST00000263646.11
ENST00000527938.5
ENST00000707519.1 [Q9H0E2-1]
ENST00000530506.5
ENST00000707520.1 [Q9H0E2-2]
Q6FIE9
ENST00000530541.1
F2Z2Y8
E9PQ25
Q9H0E2
E9PNS3
ENST00000525159.5
ENST00000527886.5 [Q9H0E2-2]
E7EN89
E9PP67