TIRAP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TIRAP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TIRAP at tissue level.

III. Associated gene sets

GO_0002755Biological processMyD88-dependent toll-like receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0071221Biological processcellular response to bacterial lipopeptide
GO_2000340Biological processpositive regulation of chemokine (C-X-C motif) ligand 1 production
GO_0032738Biological processpositive regulation of interleukin-15 production
GO_0045087Biological processinnate immune response
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0035665Biological processTIRAP-dependent toll-like receptor 4 signaling pathway
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_2000343Biological processpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO_0034137Biological processpositive regulation of toll-like receptor 2 signaling pathway
GO_0045088Biological processregulation of innate immune response
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0030099Biological processmyeloid cell differentiation
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0071223Biological processcellular response to lipoteichoic acid
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0032648Biological processregulation of interferon-beta production
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0070935Biological process3'-UTR-mediated mRNA stabilization
GO_0090023Biological processpositive regulation of neutrophil chemotaxis
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0034141Biological processpositive regulation of toll-like receptor 3 signaling pathway
GO_0032496Biological processresponse to lipopolysaccharide
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0007166Biological processcell surface receptor signaling pathway
GO_0032587Cellular componentruffle membrane
GO_0005886Cellular componentplasma membrane
GO_0030139Cellular componentendocytic vesicle
GO_0031234Cellular componentextrinsic component of cytoplasmic side of plasma membrane
GO_0009986Cellular componentcell surface
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005080Molecular functionprotein kinase C binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0035663Molecular functionToll-like receptor 2 binding
GO_0042802Molecular functionidentical protein binding
GO_0035662Molecular functionToll-like receptor 4 binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTIRAP
Protein nameTIR domain containing adaptor protein
Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)
SynonymsMAL
DescriptionFUNCTION: Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6). .

AccessionsENST00000479770.2 [P58753-1]
ENST00000700491.1 [P58753-2]
P58753
ENST00000700495.1
ENST00000700488.1 [P58753-1]
ENST00000700489.1 [P58753-1]
A0A8V8TPR1
ENST00000392680.6 [P58753-1]
ENST00000700492.1 [P58753-2]
ENST00000700490.1 [P58753-1]
ENST00000488598.5
ENST00000392678.7 [P58753-2]
ENST00000392679.6 [P58753-1]
F5H2K1