MIF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042327Biological processpositive regulation of phosphorylation
GO_0002906Biological processnegative regulation of mature B cell apoptotic process
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0006954Biological processinflammatory response
GO_0010629Biological processnegative regulation of gene expression
GO_0045087Biological processinnate immune response
GO_0050918Biological processpositive chemotaxis
GO_0031666Biological processpositive regulation of lipopolysaccharide-mediated signaling pathway
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0043030Biological processregulation of macrophage activation
GO_0070207Biological processprotein homotrimerization
GO_0090238Biological processpositive regulation of arachidonic acid secretion
GO_0061081Biological processpositive regulation of myeloid leukocyte cytokine production involved in immune response
GO_0033033Biological processnegative regulation of myeloid cell apoptotic process
GO_2000343Biological processpositive regulation of chemokine (C-X-C motif) ligand 2 production
GO_0051248Biological processnegative regulation of protein metabolic process
GO_0043066Biological processnegative regulation of apoptotic process
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0010739Biological processpositive regulation of protein kinase A signaling
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0001516Biological processprostaglandin biosynthetic process
GO_0010760Biological processnegative regulation of macrophage chemotaxis
GO_1902166Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0019752Biological processcarboxylic acid metabolic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0030336Biological processnegative regulation of cell migration
GO_0090398Biological processcellular senescence
GO_0001819Biological processpositive regulation of cytokine production
GO_0061078Biological processpositive regulation of prostaglandin secretion involved in immune response
GO_0043518Biological processnegative regulation of DNA damage response, signal transduction by p53 class mediator
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_2000773Biological processnegative regulation of cellular senescence
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0034774Cellular componentsecretory granule lumen
GO_0009986Cellular componentcell surface
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031982Cellular componentvesicle
GO_0004167Molecular functiondopachrome isomerase activity
GO_0005126Molecular functioncytokine receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0002020Molecular functionprotease binding
GO_0042056Molecular functionchemoattractant activity
GO_0050178Molecular functionphenylpyruvate tautomerase activity
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameMIF
Protein nameMacrophage migration inhibitory factor (MIF) (EC 5.3.2.1) (Glycosylation-inhibiting factor) (GIF) (L-dopachrome isomerase) (L-dopachrome tautomerase) (EC 5.3.3.12) (Phenylpyruvate tautomerase)
Macrophage migration inhibitory factor (EC 5.3.2.1) (EC 5.3.3.12) (L-dopachrome isomerase) (L-dopachrome tautomerase) (Phenylpyruvate tautomerase)
SynonymsGLIF
MMIF
DescriptionFUNCTION: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens . The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense . Counteracts the anti-inflammatory activity of glucocorticoids . Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known . It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity . .

AccessionsP14174
ENST00000215754.8
I4AY87
ENST00000613839.2
A6MUU8