SLC11A1 | OmnibusX

Name	Number of supported studies	Average coverage
macrophage	31 studies	39% ± 17%	Explore
classical monocyte	26 studies	53% ± 14%	Explore
monocyte	23 studies	43% ± 19%	Explore
non-classical monocyte	23 studies	58% ± 12%	Explore
neutrophil	14 studies	53% ± 17%	Explore
microglial cell	11 studies	43% ± 16%	Explore
myeloid cell	11 studies	39% ± 20%	Explore
alveolar macrophage	8 studies	81% ± 11%	Explore
dendritic cell	5 studies	33% ± 11%	Explore
intermediate monocyte	5 studies	58% ± 22%	Explore
mononuclear phagocyte	3 studies	42% ± 16%	Explore
inflammatory macrophage	3 studies	46% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	10 studies	21% ± 6%	Explore
lung	8 studies	24% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	29041.09	578 / 578	91%	10.33	1056 / 1155
bladder	62%	2089.00	13 / 21	59%	4.43	297 / 504
breast	53%	1619.82	242 / 459	57%	2.72	640 / 1118
esophagus	30%	652.28	438 / 1445	76%	4.45	139 / 183
adrenal gland	86%	2659.88	222 / 258	20%	1.12	46 / 230
pancreas	18%	444.98	58 / 328	87%	12.79	155 / 178
ovary	18%	307.96	33 / 180	86%	5.06	371 / 430
brain	22%	694.66	584 / 2642	81%	14.88	572 / 705
kidney	34%	741.49	30 / 89	68%	4.23	613 / 901
spleen	100%	23839.78	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.88	1 / 1
thymus	40%	725.03	258 / 653	55%	2.35	332 / 605
intestine	38%	873.98	363 / 966	55%	3.78	288 / 527
uterus	22%	458.51	37 / 170	67%	3.51	306 / 459
stomach	28%	729.20	101 / 359	60%	3.88	172 / 286
peripheral blood	81%	63682.26	755 / 929	0%	0	0 / 0
adipose	76%	4471.35	915 / 1204	0%	0	0 / 0
prostate	34%	838.66	83 / 245	31%	0.92	157 / 502
skin	8%	150.47	150 / 1809	46%	2.36	215 / 472
blood vessel	50%	1686.19	668 / 1335	0%	0	0 / 0
liver	33%	879.49	75 / 226	16%	0.93	65 / 406
tonsil	0%	0	0 / 0	49%	2.40	22 / 45
heart	46%	1332.66	395 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	34%	3.32	10 / 29
muscle	7%	104.74	55 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045454	Biological process	cell redox homeostasis
GO_0006828	Biological process	manganese ion transport
GO_0050766	Biological process	positive regulation of phagocytosis
GO_0045730	Biological process	respiratory burst
GO_0042116	Biological process	macrophage activation
GO_0006954	Biological process	inflammatory response
GO_0009617	Biological process	response to bacterium
GO_0042832	Biological process	defense response to protozoan
GO_0050829	Biological process	defense response to Gram-negative bacterium
GO_1902600	Biological process	proton transmembrane transport
GO_0010628	Biological process	positive regulation of gene expression
GO_1903826	Biological process	L-arginine transmembrane transport
GO_0034755	Biological process	iron ion transmembrane transport
GO_0045342	Biological process	MHC class II biosynthetic process
GO_0048255	Biological process	mRNA stabilization
GO_0002606	Biological process	positive regulation of dendritic cell antigen processing and presentation
GO_0060586	Biological process	multicellular organismal-level iron ion homeostasis
GO_0006826	Biological process	iron ion transport
GO_0032496	Biological process	response to lipopolysaccharide
GO_0071421	Biological process	manganese ion transmembrane transport
GO_0030001	Biological process	metal ion transport
GO_0051649	Biological process	establishment of localization in cell
GO_0034341	Biological process	response to type II interferon
GO_0042060	Biological process	wound healing
GO_0048002	Biological process	antigen processing and presentation of peptide antigen
GO_0019730	Biological process	antimicrobial humoral response
GO_0032147	Biological process	activation of protein kinase activity
GO_0006879	Biological process	intracellular iron ion homeostasis
GO_0098849	Biological process	cellular detoxification of cadmium ion
GO_0006909	Biological process	phagocytosis
GO_0001818	Biological process	negative regulation of cytokine production
GO_0042742	Biological process	defense response to bacterium
GO_0007035	Biological process	vacuolar acidification
GO_0032729	Biological process	positive regulation of type II interferon production
GO_0002309	Biological process	T cell proliferation involved in immune response
GO_0001819	Biological process	positive regulation of cytokine production
GO_0002827	Biological process	positive regulation of T-helper 1 type immune response
GO_0015707	Biological process	nitrite transport
GO_0070574	Biological process	cadmium ion transmembrane transport
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0031902	Cellular component	late endosome membrane
GO_0005886	Cellular component	plasma membrane
GO_0005764	Cellular component	lysosome
GO_0070821	Cellular component	tertiary granule membrane
GO_0005770	Cellular component	late endosome
GO_0030670	Cellular component	phagocytic vesicle membrane
GO_0101003	Cellular component	ficolin-1-rich granule membrane
GO_0010008	Cellular component	endosome membrane
GO_0005765	Cellular component	lysosomal membrane
GO_0042803	Molecular function	protein homodimerization activity
GO_0015086	Molecular function	cadmium ion transmembrane transporter activity
GO_0051139	Molecular function	metal cation:proton antiporter activity
GO_0005381	Molecular function	iron ion transmembrane transporter activity
GO_0005384	Molecular function	manganese ion transmembrane transporter activity
GO_0046915	Molecular function	transition metal ion transmembrane transporter activity

IV. Literature review

[source]

Gene name	SLC11A1
Protein name	Natural resistance-associated macrophage protein 1 Natural resistance-associated macrophage protein 1 (NRAMP 1) (Solute carrier family 11 member 1) Natural resistance-associated macrophage protein 1 (Solute carrier family 11 member 1) Solute carrier family 11 member 1
Synonyms	NRAMP LSH NRAMP1
Description	FUNCTION: Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity . Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (Probable). .
Accessions	ENST00000233202.11 [P49279-1] Q9HBK0 ENST00000354352.9 A0A0M4AZU7 ENST00000481524.5 P49279 A0A087X2D6 ENST00000473367.5 Q8NDV6 A0A087X181 A0A0A0MTL3 A0A0M3PPS2 ENST00000539932.5

SLC11A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review