PLA2G4C | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
oligodendrocyte	12 studies	32% ± 10%	Explore
retinal rod cell	8 studies	36% ± 14%	Explore
endothelial cell	5 studies	21% ± 3%	Explore
astrocyte	5 studies	29% ± 7%	Explore
glutamatergic neuron	4 studies	49% ± 21%	Explore
retinal bipolar neuron	4 studies	26% ± 5%	Explore
Mueller cell	4 studies	35% ± 9%	Explore
endothelial cell of lymphatic vessel	4 studies	21% ± 3%	Explore
GABAergic neuron	4 studies	42% ± 18%	Explore
rod bipolar cell	3 studies	22% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	26% ± 7%	Explore
interneuron	3 studies	36% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
eye	6 studies	32% ± 11%	Explore
brain	6 studies	39% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	2068.43	2641 / 2642	99%	13.46	701 / 705
adrenal gland	100%	2428.50	258 / 258	98%	13.37	226 / 230
kidney	97%	862.01	86 / 89	93%	8.62	838 / 901
prostate	93%	780.42	227 / 245	93%	7.33	467 / 502
thymus	97%	826.90	636 / 653	86%	4.44	518 / 605
breast	90%	695.51	415 / 459	86%	4.96	958 / 1118
lung	99%	1243.31	571 / 578	56%	2.47	651 / 1155
liver	57%	300.07	129 / 226	89%	8.56	363 / 406
skin	51%	252.14	930 / 1809	91%	10.49	429 / 472
uterus	96%	850.69	163 / 170	46%	2.51	209 / 459
pancreas	50%	233.82	163 / 328	76%	3.58	136 / 178
intestine	87%	780.41	844 / 966	37%	1.60	195 / 527
bladder	86%	662.29	18 / 21	33%	1.52	168 / 504
esophagus	71%	664.44	1020 / 1445	42%	2.01	76 / 183
muscle	100%	4051.22	803 / 803	0%	0	0 / 0
spleen	100%	1640.96	241 / 241	0%	0	0 / 0
blood vessel	99%	1044.03	1318 / 1335	0%	0	0 / 0
heart	98%	1521.29	848 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	14.27	78 / 80
stomach	44%	372.47	158 / 359	50%	2.57	142 / 286
lymph node	0%	0	0 / 0	93%	5.76	27 / 29
adipose	87%	700.75	1050 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	67%	4.28	30 / 45
ovary	37%	168.52	66 / 180	17%	0.54	74 / 430
peripheral blood	19%	138.33	172 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0036151	Biological process	phosphatidylcholine acyl-chain remodeling
GO_0006954	Biological process	inflammatory response
GO_0006663	Biological process	platelet activating factor biosynthetic process
GO_0140042	Biological process	lipid droplet formation
GO_0036152	Biological process	phosphatidylethanolamine acyl-chain remodeling
GO_0035556	Biological process	intracellular signal transduction
GO_0046475	Biological process	glycerophospholipid catabolic process
GO_0006644	Biological process	phospholipid metabolic process
GO_0019369	Biological process	arachidonic acid metabolic process
GO_0007567	Biological process	parturition
GO_0005886	Cellular component	plasma membrane
GO_0005811	Cellular component	lipid droplet
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0031966	Cellular component	mitochondrial membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005635	Cellular component	nuclear envelope
GO_0005829	Cellular component	cytosol
GO_0005938	Cellular component	cell cortex
GO_0008970	Molecular function	phospholipase A1 activity
GO_0047498	Molecular function	calcium-dependent phospholipase A2 activity
GO_0008374	Molecular function	O-acyltransferase activity
GO_0005544	Molecular function	calcium-dependent phospholipid binding
GO_0005543	Molecular function	phospholipid binding
GO_0047499	Molecular function	calcium-independent phospholipase A2 activity
GO_0004622	Molecular function	lysophospholipase activity
GO_0102545	Molecular function	phosphatidyl phospholipase B activity
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PLA2G4C
Protein name	Phospholipase A2, group IVC(Cytosolic, calcium-independent) PLA2G4C protein Phospholipase A2 group IVC Cytosolic phospholipase A2 gamma (cPLA2-gamma) (EC 3.1.1.4) (Cytosolic lysophospholipase) (EC 3.1.1.5) (Cytosolic lysophospholipid O-acyltransferase) (EC 2.3.1.-) (Phospholipase A2 group IVC)
Synonyms
Description	FUNCTION: Calcium-independent phospholipase, lysophospholipase and O-acyltransferase involved in phospholipid remodeling with implications in endoplasmic reticulum membrane homeostasis and lipid droplet biogenesis . Preferentially hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids with choline and ethanolamine head groups, producing lysophospholipids that are used in deacylation-reacylation cycles . Transfers the sn-1 fatty acyl from one lysophospholipid molecule to the sn-2 position of another lysophospholipid to form diacyl, alkylacyl and alkenylacyl glycerophospholipids. Cleaves ester bonds but not alkyl or alkenyl ether bonds at sn-1 position of lysophospholipids . Catalyzes sn-2 fatty acyl transfer from phospholipids to the sn-2 position of 1-O-alkyl or 1-O-alkenyl lysophospholipids with lower efficiency . In response to dietary fatty acids, may play a role in the formation of nascent lipid droplets from the endoplasmic reticulum likely by regulating the phospholipid composition of these organelles . .; FUNCTION: (Microbial infection) May play a role in replication and assembly of human hepatitis C virus (HCV) . In response to HCV infection, promotes remodeling of host endoplasmic reticulum membranes to form organelle-like structures called membranous web, where HCV replication occur . Can further mediate translocation of replication complexes to lipid droplets to enable virion assembly . .; FUNCTION: (Microbial infection) May facilitate human T-lymphotropic virus type 1 (HTLV-1) infection by promoting leukotriene B4 (LTB4) biosynthesis. LTB4 acts as a chemoattractant for HTLV-1-infected CD4-positive T cells and favors cell to cell viral transmission. .
Accessions	ENST00000595161.5 M0R339 ENST00000599921.6 [Q9UP65-1] M0R0M8 M0QX83 ENST00000599111.5 [Q9UP65-3] Q8WWC5 ENST00000596138.1 ENST00000597713.1 Q76EZ0 Q9UP65 M0R0F6 M0QZB1 ENST00000596352.5 M0QY18 M0R1B4 ENST00000601946.1 ENST00000595487.5 M0R3I9 ENST00000354276.7 [Q9UP65-2] ENST00000598488.1 ENST00000599300.5 Q76EY9

PLA2G4C report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review