Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type II pneumocyte | 11 studies | 41% ± 15% | |
| adipocyte | 10 studies | 54% ± 27% | |
| epithelial cell | 6 studies | 24% ± 8% | |
| hepatocyte | 5 studies | 38% ± 18% | |
| endothelial cell | 4 studies | 25% ± 8% | |
| retinal ganglion cell | 4 studies | 61% ± 24% | |
| luminal hormone-sensing cell of mammary gland | 4 studies | 32% ± 3% | |
| abnormal cell | 4 studies | 26% ± 7% | |
| neuron | 3 studies | 20% ± 4% | |
| GABAergic neuron | 3 studies | 22% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 4 studies | 24% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 98% | 33865.63 | 241 / 245 | 99% | 572.68 | 499 / 502 |
| breast | 99% | 125053.39 | 453 / 459 | 97% | 427.86 | 1083 / 1118 |
| skin | 100% | 29128.27 | 1803 / 1809 | 95% | 246.00 | 449 / 472 |
| stomach | 93% | 21697.23 | 333 / 359 | 94% | 142.33 | 268 / 286 |
| liver | 96% | 44666.22 | 218 / 226 | 90% | 219.12 | 365 / 406 |
| esophagus | 85% | 14542.87 | 1225 / 1445 | 99% | 198.79 | 181 / 183 |
| brain | 89% | 15033.77 | 2352 / 2642 | 93% | 109.71 | 653 / 705 |
| bladder | 86% | 11167.24 | 18 / 21 | 93% | 149.06 | 469 / 504 |
| lung | 83% | 26431.81 | 480 / 578 | 89% | 126.78 | 1027 / 1155 |
| intestine | 77% | 9250.13 | 742 / 966 | 92% | 131.66 | 487 / 527 |
| uterus | 70% | 6123.28 | 119 / 170 | 85% | 97.79 | 390 / 459 |
| adrenal gland | 91% | 13286.86 | 236 / 258 | 53% | 49.96 | 123 / 230 |
| ovary | 58% | 5333.38 | 105 / 180 | 87% | 97.79 | 372 / 430 |
| ureter | 0% | 0 | 0 / 0 | 100% | 61.83 | 1 / 1 |
| adipose | 99% | 156055.26 | 1190 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 81% | 9625.77 | 527 / 653 | 18% | 10.57 | 108 / 605 |
| eye | 0% | 0 | 0 / 0 | 98% | 146.38 | 78 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 81.74 | 40 / 45 |
| pancreas | 31% | 2742.87 | 102 / 328 | 53% | 39.94 | 94 / 178 |
| blood vessel | 63% | 11158.90 | 839 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 27.30 | 12 / 29 |
| kidney | 29% | 3162.60 | 26 / 89 | 12% | 7.71 | 104 / 901 |
| muscle | 36% | 6179.74 | 291 / 803 | 0% | 0 | 0 / 0 |
| heart | 23% | 3401.46 | 199 / 861 | 0% | 0 | 0 / 0 |
| spleen | 22% | 1417.95 | 53 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 20% | 4336.09 | 188 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0030879 | Biological process | mammary gland development |
| GO_0008611 | Biological process | ether lipid biosynthetic process |
| GO_0006954 | Biological process | inflammatory response |
| GO_0030223 | Biological process | neutrophil differentiation |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0002068 | Biological process | glandular epithelial cell development |
| GO_0071353 | Biological process | cellular response to interleukin-4 |
| GO_0006631 | Biological process | fatty acid metabolic process |
| GO_0006633 | Biological process | fatty acid biosynthetic process |
| GO_0044788 | Biological process | modulation by host of viral process |
| GO_0090557 | Biological process | establishment of endothelial intestinal barrier |
| GO_0030224 | Biological process | monocyte differentiation |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0042587 | Cellular component | glycogen granule |
| GO_0016020 | Cellular component | membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0042470 | Cellular component | melanosome |
| GO_0031177 | Molecular function | phosphopantetheine binding |
| GO_0004312 | Molecular function | fatty acid synthase activity |
| GO_0016297 | Molecular function | fatty acyl-[ACP] hydrolase activity |
| GO_0008693 | Molecular function | (3R)-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity |
| GO_0045296 | Molecular function | cadherin binding |
| GO_0047450 | Molecular function | (3R)-3-hydroxybutanoyl-[acyl-carrier-protein] hydratase activity |
| GO_0008659 | Molecular function | (3R)-3-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity |
| GO_0004313 | Molecular function | [acyl-carrier-protein] S-acetyltransferase activity |
| GO_0004317 | Molecular function | (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity |
| GO_0047451 | Molecular function | (3R)-3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity |
| GO_0004315 | Molecular function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| GO_0004316 | Molecular function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| GO_0141148 | Molecular function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
| GO_0003723 | Molecular function | RNA binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004314 | Molecular function | [acyl-carrier-protein] S-malonyltransferase activity |
| Gene name | FASN |
| Protein name | Fatty acid synthase (EC 1.1.1.100) (EC 1.3.1.39) (EC 2.3.1.38) (EC 2.3.1.39) (EC 2.3.1.41) (EC 2.3.1.85) (EC 3.1.2.14) (EC 4.2.1.59) Fatty acid synthase (EC 2.3.1.85) Fatty acid synthase Fatty acid synthase (EC 2.3.1.85) (Type I fatty acid synthase) [Includes: [Acyl-carrier-protein] S-acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.39); Acyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)] |
| Synonyms | FAS |
| Description | FUNCTION: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. . FUNCTION: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. .; FUNCTION: (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. . |
| Accessions | Q6PJJ3 ENST00000306749.4 ENST00000634990.1 ENST00000635197.1 ENST00000637026.1 ENST00000636628.1 A0A1B0GWG8 ENST00000580382.1 A0A0U1RRG3 J3KTF0 A0A1B0GVK4 ENST00000636968.1 P49327 A0A0U1RQF0 A0A1B0GTR5 |
