TNFAIP3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000349Biological processnegative regulation of CD40 signaling pathway
GO_0071108Biological processprotein K48-linked deubiquitination
GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_2000347Biological processpositive regulation of hepatocyte proliferation
GO_0006954Biological processinflammatory response
GO_0070429Biological processnegative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO_0070433Biological processnegative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0034136Biological processnegative regulation of toll-like receptor 2 signaling pathway
GO_0035523Biological processprotein K29-linked deubiquitination
GO_0061043Biological processregulation of vascular wound healing
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0045779Biological processnegative regulation of bone resorption
GO_0001922Biological processB-1 B cell homeostasis
GO_0002634Biological processregulation of germinal center formation
GO_0032495Biological processresponse to muramyl dipeptide
GO_0002237Biological processresponse to molecule of bacterial origin
GO_1990168Biological processprotein K33-linked deubiquitination
GO_0002677Biological processnegative regulation of chronic inflammatory response
GO_0034144Biological processnegative regulation of toll-like receptor 4 signaling pathway
GO_0071947Biological processprotein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO_0007010Biological processcytoskeleton organization
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0045824Biological processnegative regulation of innate immune response
GO_0070936Biological processprotein K48-linked ubiquitination
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0050728Biological processnegative regulation of inflammatory response
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0090291Biological processnegative regulation of osteoclast proliferation
GO_0006508Biological processproteolysis
GO_0034140Biological processnegative regulation of toll-like receptor 3 signaling pathway
GO_0048662Biological processnegative regulation of smooth muscle cell proliferation
GO_0016579Biological processprotein deubiquitination
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006915Biological processapoptotic process
GO_1902042Biological processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0072666Biological processestablishment of protein localization to vacuole
GO_0034148Biological processnegative regulation of toll-like receptor 5 signaling pathway
GO_0072573Biological processtolerance induction to lipopolysaccharide
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0050691Biological processregulation of defense response to virus by host
GO_0035871Biological processprotein K11-linked deubiquitination
GO_0050869Biological processnegative regulation of B cell activation
GO_0016477Biological processcell migration
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0035872Biological processnucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_0005764Cellular componentlysosome
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0004843Molecular functioncysteine-type deubiquitinase activity
GO_0019900Molecular functionkinase binding
GO_0042802Molecular functionidentical protein binding
GO_0002020Molecular functionprotease binding
GO_0008270Molecular functionzinc ion binding
GO_0061578Molecular functionK63-linked deubiquitinase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameTNFAIP3
Protein nameTruncated tumor necrosis factor alpha-induced protein 3
ubiquitinyl hydrolase 1 (EC 3.4.19.12)
Tumor necrosis factor alpha-induced protein 3
Tumor necrosis factor alpha-induced protein 3 (TNF alpha-induced protein 3) (EC 2.3.2.-) (EC 3.4.19.12) (OTU domain-containing protein 7C) (Putative DNA-binding protein A20) (Zinc finger protein A20) [Cleaved into: A20p50; A20p37]
TNF alpha induced protein 3
TNFAIP3 (A20)
SynonymsOTUD7C
DescriptionFUNCTION: Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages. .

AccessionsD3TTZ6
D3TTZ4
ENST00000711061.1
D3TTZ5
Q5VXQ9
ENST00000421450.1
D3TTZ3
D3TTZ2
ENST00000420009.5
D3TTZ8
P21580
ENST00000420009.6
Q5VXR0
F8K9X7
ENST00000433680.1
D3TTZ7
ENST00000237289.8
A0AA34QW12
D3TTY9
D3TTY6
D3TTY8
D3TTY5
D3TTZ0
ENST00000612899.5
D3TTY7
D3TTZ1
ENST00000433680.2
ENST00000421450.2
D3TTY4
Q5VXQ8