LACC1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LACC1 at tissue level.

III. Associated gene sets

GO_0002221Biological processpattern recognition receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0045087Biological processinnate immune response
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0050727Biological processregulation of inflammatory response
GO_0070431Biological processnucleotide-binding oligomerization domain containing 2 signaling pathway
GO_1900542Biological processregulation of purine nucleotide metabolic process
GO_0030641Biological processregulation of cellular pH
GO_0005634Cellular componentnucleus
GO_0005777Cellular componentperoxisome
GO_0005783Cellular componentendoplasmic reticulum
GO_0016682Molecular functionoxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO_0017061Molecular functionS-methyl-5-thioadenosine phosphorylase activity
GO_0047975Molecular functionguanosine phosphorylase activity
GO_0004731Molecular functionpurine-nucleoside phosphorylase activity
GO_0046936Molecular function2'-deoxyadenosine deaminase activity
GO_0005507Molecular functioncopper ion binding
GO_0005515Molecular functionprotein binding
GO_0004000Molecular functionadenosine deaminase activity

IV. Literature review

[source]
Gene nameLACC1
Protein namePurine nucleoside phosphorylase LACC1 (EC 2.4.2.1) (Adenosine deaminase LACC1) (EC 3.5.4.4) (Fatty acid metabolism-immunity nexus) (Guanosine phosphorylase LACC1) (Laccase domain-containing protein 1) (S-methyl-5'-thioadenosine phosphorylase LACC1) (EC 2.4.2.28)
Laccase domain containing 1
SynonymsC13orf31
FAMIN
DescriptionFUNCTION: Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine . Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate . Also has adenosine deaminase activity . Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages . Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface . The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity . Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance . Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) . Does not show laccase activity . .

AccessionsQ8IV20
A2A3Z5
ENST00000441843.5
ENST00000425906.1
ENST00000325686.7