Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 100% | 1048.82 | 577 / 578 | 93% | 20.07 | 1069 / 1155 |
stomach | 88% | 182.99 | 315 / 359 | 78% | 19.97 | 223 / 286 |
breast | 72% | 158.53 | 329 / 459 | 81% | 12.66 | 905 / 1118 |
uterus | 71% | 111.09 | 121 / 170 | 79% | 17.47 | 363 / 459 |
prostate | 85% | 180.51 | 208 / 245 | 63% | 6.78 | 317 / 502 |
thymus | 82% | 187.19 | 536 / 653 | 65% | 11.87 | 391 / 605 |
kidney | 66% | 128.65 | 59 / 89 | 80% | 21.23 | 723 / 901 |
bladder | 76% | 211.57 | 16 / 21 | 66% | 13.67 | 333 / 504 |
liver | 93% | 222.88 | 211 / 226 | 48% | 6.38 | 196 / 406 |
intestine | 63% | 148.73 | 610 / 966 | 77% | 13.33 | 407 / 527 |
adrenal gland | 85% | 181.05 | 219 / 258 | 53% | 9.62 | 121 / 230 |
ovary | 37% | 48.66 | 66 / 180 | 83% | 16.17 | 359 / 430 |
esophagus | 43% | 50.70 | 618 / 1445 | 74% | 11.71 | 136 / 183 |
spleen | 100% | 2326.26 | 241 / 241 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 4570.54 | 918 / 929 | 0% | 0 | 0 / 0 |
brain | 21% | 56.41 | 547 / 2642 | 78% | 40.68 | 548 / 705 |
lymph node | 0% | 0 | 0 / 0 | 97% | 94.66 | 28 / 29 |
pancreas | 20% | 22.64 | 66 / 328 | 75% | 10.48 | 133 / 178 |
tonsil | 0% | 0 | 0 / 0 | 91% | 29.83 | 41 / 45 |
adipose | 84% | 368.89 | 1007 / 1204 | 0% | 0 | 0 / 0 |
skin | 7% | 7.58 | 135 / 1809 | 74% | 21.32 | 347 / 472 |
blood vessel | 58% | 172.33 | 771 / 1335 | 0% | 0 | 0 / 0 |
heart | 38% | 55.06 | 330 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 19% | 3.09 | 15 / 80 |
muscle | 3% | 2.84 | 23 / 803 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0006954 | Biological process | inflammatory response |
GO_0050850 | Biological process | positive regulation of calcium-mediated signaling |
GO_0043547 | Biological process | positive regulation of GTPase activity |
GO_0007165 | Biological process | signal transduction |
GO_0009615 | Biological process | response to virus |
GO_0043922 | Biological process | negative regulation by host of viral transcription |
GO_0007163 | Biological process | establishment or maintenance of cell polarity |
GO_0007155 | Biological process | cell adhesion |
GO_0007267 | Biological process | cell-cell signaling |
GO_0006955 | Biological process | immune response |
GO_0070098 | Biological process | chemokine-mediated signaling pathway |
GO_0030335 | Biological process | positive regulation of cell migration |
GO_2000503 | Biological process | positive regulation of natural killer cell chemotaxis |
GO_0048245 | Biological process | eosinophil chemotaxis |
GO_0051928 | Biological process | positive regulation of calcium ion transport |
GO_0061844 | Biological process | antimicrobial humoral immune response mediated by antimicrobial peptide |
GO_0009636 | Biological process | response to toxic substance |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0031726 | Molecular function | CCR1 chemokine receptor binding |
GO_0031730 | Molecular function | CCR5 chemokine receptor binding |
GO_0008009 | Molecular function | chemokine activity |
GO_0048020 | Molecular function | CCR chemokine receptor binding |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0005125 | Molecular function | cytokine activity |
Gene name | CCL4 |
Protein name | Chemokine C-C motif ligand 4 C-C motif chemokine 4 (C-C motif chemokine ligand 4) (CC chemokine ligand 4d2) (Monocyte adherence-induced protein 5 alpha) C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)] |
Synonyms | MIP1B SCYA4 LAG1 |
Description | FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. . |
Accessions | ENST00000621600.4 ENST00000621626.1 ENST00000610612.1 Q6JSE0 P13236 ENST00000613036.1 ENST00000615863.2 ENST00000617322.4 Q7M4M2 |