CCL4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007165Biological processsignal transduction
GO_0009615Biological processresponse to virus
GO_0043922Biological processnegative regulation by host of viral transcription
GO_0007163Biological processestablishment or maintenance of cell polarity
GO_0007155Biological processcell adhesion
GO_0007267Biological processcell-cell signaling
GO_0006955Biological processimmune response
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_2000503Biological processpositive regulation of natural killer cell chemotaxis
GO_0048245Biological processeosinophil chemotaxis
GO_0051928Biological processpositive regulation of calcium ion transport
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0009636Biological processresponse to toxic substance
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0031726Molecular functionCCR1 chemokine receptor binding
GO_0031730Molecular functionCCR5 chemokine receptor binding
GO_0008009Molecular functionchemokine activity
GO_0048020Molecular functionCCR chemokine receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameCCL4
Protein nameChemokine C-C motif ligand 4
C-C motif chemokine 4 (C-C motif chemokine ligand 4) (CC chemokine ligand 4d2) (Monocyte adherence-induced protein 5 alpha)
C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
SynonymsMIP1B
SCYA4
LAG1
DescriptionFUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. .

AccessionsENST00000621600.4
ENST00000621626.1
ENST00000610612.1
Q6JSE0
P13236
ENST00000613036.1
ENST00000615863.2
ENST00000617322.4
Q7M4M2