NOD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0098792Biological processxenophagy
GO_0070427Biological processnucleotide-binding oligomerization domain containing 1 signaling pathway
GO_0002221Biological processpattern recognition receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0032874Biological processpositive regulation of stress-activated MAPK cascade
GO_0016045Biological processdetection of bacterium
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0045087Biological processinnate immune response
GO_0046330Biological processpositive regulation of JNK cascade
GO_0007165Biological processsignal transduction
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0002606Biological processpositive regulation of dendritic cell antigen processing and presentation
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1904417Biological processpositive regulation of xenophagy
GO_0051403Biological processstress-activated MAPK cascade
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0070371Biological processERK1 and ERK2 cascade
GO_0035556Biological processintracellular signal transduction
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0042742Biological processdefense response to bacterium
GO_0060907Biological processpositive regulation of macrophage cytokine production
GO_0009595Biological processdetection of biotic stimulus
GO_0006915Biological processapoptotic process
GO_0071225Biological processcellular response to muramyl dipeptide
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0043065Biological processpositive regulation of apoptotic process
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0006952Biological processdefense response
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0005829Cellular componentcytosol
GO_0045335Cellular componentphagocytic vesicle
GO_0005737Cellular componentcytoplasm
GO_0016323Cellular componentbasolateral plasma membrane
GO_0050700Molecular functionCARD domain binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0042834Molecular functionpeptidoglycan binding
GO_0038187Molecular functionpattern recognition receptor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0008656Molecular functioncysteine-type endopeptidase activator activity involved in apoptotic process
GO_0042802Molecular functionidentical protein binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameNOD1
Protein nameNucleotide-binding oligomerization domain-containing protein 1 (hNod1) (Caspase recruitment domain-containing protein 4)
Nucleotide-binding oligomerization domain containing 1 isoform 2 (Nucleotide-binding oligomerization domain containing 1 isoform 3) (Nucleotide-binding oligomerization domain containing 1 isoform 4)
Nucleotide binding oligomerization domain containing 1
Caspase recruitment domain family, member 4 (Nucleotide-binding oligomerization domain containing 1 isoform 1)
Caspase recruitment domain family, member 4, isoform CRA_c (Nucleotide binding oligomerization domain containing 1)
SynonymshCG_39138
CARD4
tcag7.679
DescriptionFUNCTION: Pattern recognition receptor (PRR) that detects bacterial peptidoglycan fragments and other danger signals and thus participates in both innate and adaptive immune responses . Specifically recognizes and binds gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP), a dipeptide present in peptidoglycan of Gram-negative bacteria . Preferentially binds iE-DAP in tripeptide-containing muropeptides (MurNAc-TriDAP or TriDAP) . Ligand binding triggers oligomerization that facilitates the binding and subsequent activation of the proximal adapter receptor-interacting RIPK2 . Following recruitment, RIPK2 undergoes 'Met-1'- (linear) and 'Lys-63'-linked polyubiquitination by E3 ubiquitin-protein ligases XIAP, BIRC2, BIRC3 and the LUBAC complex, becoming a scaffolding protein for downstream effectors, triggering activation of the NF-kappa-B and MAP kinases signaling . This in turn leads to the transcriptional activation of hundreds of genes involved in immune response . Also acts as a regulator of antiviral response elicited by dsRNA and the expression of RLR pathway members by targeting IFIH1 and TRAF3 to modulate the formation of IFIH1-MAVS and TRAF3-MAVS complexes leading to increased transcription of type I IFNs . Also acts as a regulator of autophagy via its interaction with ATG16L1, possibly by recruiting ATG16L1 at the site of bacterial entry (By similarity). Besides recognizing pathogens, also involved in the endoplasmic reticulum stress response: acts by sensing and binding to the cytosolic metabolite sphingosine-1-phosphate generated in response to endoplasmic reticulum stress, initiating an inflammation process that leads to activation of the NF-kappa-B and MAP kinases signaling . In addition, plays a role in insulin trafficking in beta cells in a cell-autonomous manner (By similarity). Mechanistically, upon recognizing cognate ligands, NOD1 and RIPK2 localize to insulin vesicles where they recruit RAB1A to direct insulin trafficking through the cytoplasm (By similarity). .; FUNCTION: [Isoform 3]: In contrast to isoform 1, does not efficiently recognize and bind gamma-D-glutamyl-meso-diaminopimelic acid (iE-DAP) ligand. .

AccessionsENST00000434755.5
A0A0S2Z4W5
ENST00000419601.1
ENST00000419799.5
A0A024RA73
ENST00000222823.9 [Q9Y239-1]
C9J8X8
A0A1B0GX71
Q9Y239
ENST00000411552.5
G3XAL1
ENST00000413433.5