ALOX15 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030838Biological processpositive regulation of actin filament polymerization
GO_0006954Biological processinflammatory response
GO_0043651Biological processlinoleic acid metabolic process
GO_2001303Biological processlipoxin A4 biosynthetic process
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0034440Biological processlipid oxidation
GO_0010811Biological processpositive regulation of cell-substrate adhesion
GO_0019395Biological processfatty acid oxidation
GO_0019372Biological processlipoxygenase pathway
GO_0002820Biological processnegative regulation of adaptive immune response
GO_0050727Biological processregulation of inflammatory response
GO_0035358Biological processregulation of peroxisome proliferator activated receptor signaling pathway
GO_1901074Biological processregulation of engulfment of apoptotic cell
GO_0071277Biological processcellular response to calcium ion
GO_0042060Biological processwound healing
GO_0043277Biological processapoptotic cell clearance
GO_0035963Biological processcellular response to interleukin-13
GO_0030282Biological processbone mineralization
GO_0042759Biological processlong-chain fatty acid biosynthetic process
GO_0001503Biological processossification
GO_0006629Biological processlipid metabolic process
GO_0019369Biological processarachidonic acid metabolic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0051122Biological processhepoxilin biosynthetic process
GO_0006646Biological processphosphatidylethanolamine biosynthetic process
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0016020Cellular componentmembrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0005829Cellular componentcytosol
GO_0050473Molecular functionarachidonate 15-lipoxygenase activity
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0005506Molecular functioniron ion binding
GO_0004052Molecular functionarachidonate 12(S)-lipoxygenase activity
GO_0016165Molecular functionlinoleate 13S-lipoxygenase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameALOX15
Protein namePolyunsaturated fatty acid lipoxygenase ALOX15 (12/15-lipoxygenase) (Arachidonate 12-lipoxygenase, leukocyte-type) (12-LOX) (EC 1.13.11.31) (Arachidonate 15-lipoxygenase) (15-LOX) (15-LOX-1) (EC 1.13.11.33) (Arachidonate omega-6 lipoxygenase) (Hepoxilin A3 synthase Alox15) (EC 1.13.11.-) (Linoleate 13S-lipoxygenase) (EC 1.13.11.12)
SynonymsLOG15
DescriptionFUNCTION: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators . It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE . It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE . May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets . Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides . Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 . .

AccessionsENST00000570836.6 [P16050-1]
ENST00000574640.1 [P16050-2]
ENST00000293761.8 [P16050-1]
P16050