I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| enterocyte | 3 studies | 25% ± 5% | |
| epithelial cell | 3 studies | 20% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| enterocyte | 3 studies | 25% ± 5% | |
| epithelial cell | 3 studies | 20% ± 3% |
Insufficient scRNA-seq data for expression of TRIM31 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 76% | 497.11 | 273 / 359 | 93% | 57.03 | 267 / 286 |
| intestine | 74% | 1276.89 | 715 / 966 | 95% | 69.93 | 501 / 527 |
| bladder | 90% | 856.19 | 19 / 21 | 59% | 38.23 | 297 / 504 |
| pancreas | 55% | 13.25 | 180 / 328 | 84% | 34.37 | 149 / 178 |
| liver | 61% | 76.26 | 138 / 226 | 43% | 7.05 | 175 / 406 |
| ureter | 0% | 0 | 0 / 0 | 100% | 127.87 | 1 / 1 |
| lung | 55% | 18.93 | 317 / 578 | 31% | 10.55 | 363 / 1155 |
| prostate | 82% | 224.67 | 202 / 245 | 1% | 0.49 | 5 / 502 |
| esophagus | 26% | 7.06 | 379 / 1445 | 49% | 32.79 | 90 / 183 |
| skin | 68% | 26.65 | 1232 / 1809 | 0% | 0 | 0 / 472 |
| adrenal gland | 66% | 10.89 | 169 / 258 | 0% | 0.02 | 1 / 230 |
| thymus | 58% | 11.53 | 378 / 653 | 0% | 0.12 | 2 / 605 |
| uterus | 16% | 3.59 | 27 / 170 | 30% | 15.48 | 136 / 459 |
| kidney | 35% | 6.01 | 31 / 89 | 1% | 0.08 | 8 / 901 |
| breast | 33% | 12.68 | 150 / 459 | 1% | 0.05 | 9 / 1118 |
| spleen | 22% | 3.35 | 53 / 241 | 0% | 0 | 0 / 0 |
| ovary | 12% | 1.42 | 21 / 180 | 3% | 0.33 | 11 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 3.00 | 6 / 45 |
| peripheral blood | 11% | 4.46 | 104 / 929 | 0% | 0 | 0 / 0 |
| adipose | 9% | 1.40 | 103 / 1204 | 0% | 0 | 0 / 0 |
| brain | 4% | 0.83 | 118 / 2642 | 0% | 0 | 0 / 705 |
| blood vessel | 1% | 0.31 | 18 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 1% | 0.09 | 6 / 803 | 0% | 0 | 0 / 0 |
| heart | 0% | 0.08 | 4 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016567 | Biological process | protein ubiquitination |
| GO_0006954 | Biological process | inflammatory response |
| GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
| GO_0045087 | Biological process | innate immune response |
| GO_1900226 | Biological process | negative regulation of NLRP3 inflammasome complex assembly |
| GO_0051607 | Biological process | defense response to virus |
| GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
| GO_0046597 | Biological process | negative regulation of viral entry into host cell |
| GO_0070936 | Biological process | protein K48-linked ubiquitination |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0070534 | Biological process | protein K63-linked ubiquitination |
| GO_0019076 | Biological process | viral release from host cell |
| GO_0032897 | Biological process | negative regulation of viral transcription |
| GO_0140374 | Biological process | antiviral innate immune response |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0061630 | Molecular function | ubiquitin protein ligase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TRIM31 |
| Protein name | E3 ubiquitin-protein ligase TRIM31 (EC 2.3.2.27) (Tripartite motif-containing protein 31) RING-type E3 ubiquitin transferase (EC 2.3.2.27) |
| Synonyms | DASS-211F20.2-001 RNF C6orf13 |
| Description | FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates . Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria . Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation . Regulator of Src-induced anchorage independent cell growth (By similarity). . |
| Accessions | A0A0G2JJX2 ENST00000453266.2 [Q9BZY9-1] ENST00000455349.2 A0A140T9J6 ENST00000433864.2 ENST00000376734.4 [Q9BZY9-1] ENST00000445679.2 [Q9BZY9-1] C4B4E3 ENST00000449412.2 [Q9BZY9-1] ENST00000422484.1 Q2L6J1 Q9BZY9 ENST00000357569.5 |
