Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| endothelial cell | 4 studies | 18% ± 2% | |
| epithelial cell | 4 studies | 22% ± 1% | |
| ciliated cell | 3 studies | 22% ± 3% | |
| GABAergic neuron | 3 studies | 27% ± 3% | |
| glutamatergic neuron | 3 studies | 33% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 25% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 1295.45 | 2639 / 2642 | 100% | 12.72 | 705 / 705 |
| breast | 100% | 1497.98 | 459 / 459 | 100% | 8.17 | 1116 / 1118 |
| bladder | 100% | 1672.24 | 21 / 21 | 100% | 8.20 | 503 / 504 |
| prostate | 100% | 2259.53 | 245 / 245 | 100% | 7.41 | 501 / 502 |
| uterus | 100% | 1920.94 | 170 / 170 | 100% | 8.58 | 458 / 459 |
| skin | 100% | 1691.93 | 1809 / 1809 | 100% | 8.36 | 470 / 472 |
| lung | 100% | 1325.31 | 577 / 578 | 100% | 7.94 | 1151 / 1155 |
| thymus | 100% | 2071.57 | 653 / 653 | 99% | 7.98 | 601 / 605 |
| ovary | 100% | 1596.76 | 180 / 180 | 99% | 6.09 | 424 / 430 |
| kidney | 100% | 1608.18 | 89 / 89 | 98% | 7.20 | 887 / 901 |
| pancreas | 100% | 898.46 | 327 / 328 | 98% | 7.05 | 175 / 178 |
| intestine | 100% | 1607.90 | 966 / 966 | 97% | 6.10 | 512 / 527 |
| esophagus | 100% | 1405.44 | 1445 / 1445 | 97% | 5.43 | 177 / 183 |
| stomach | 100% | 1216.46 | 359 / 359 | 97% | 5.32 | 276 / 286 |
| adrenal gland | 100% | 1355.17 | 258 / 258 | 95% | 5.71 | 219 / 230 |
| liver | 100% | 786.96 | 226 / 226 | 79% | 3.48 | 321 / 406 |
| adipose | 100% | 1197.72 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 6.68 | 29 / 29 |
| spleen | 100% | 1797.04 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.07 | 1 / 1 |
| blood vessel | 100% | 1034.29 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 8.22 | 79 / 80 |
| heart | 99% | 737.06 | 849 / 861 | 0% | 0 | 0 / 0 |
| muscle | 98% | 633.67 | 788 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 7.19 | 44 / 45 |
| peripheral blood | 70% | 449.94 | 647 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006954 | Biological process | inflammatory response |
| GO_0032259 | Biological process | methylation |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0018026 | Biological process | peptidyl-lysine monomethylation |
| GO_0071863 | Biological process | regulation of cell proliferation in bone marrow |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0018023 | Biological process | peptidyl-lysine trimethylation |
| GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
| GO_0032755 | Biological process | positive regulation of interleukin-6 production |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0042800 | Molecular function | histone H3K4 methyltransferase activity |
| GO_0140944 | Molecular function | histone H4K20 monomethyltransferase activity |
| GO_0140941 | Molecular function | histone H4K20me methyltransferase activity |
| GO_0042799 | Molecular function | histone H4K20 methyltransferase activity |
| GO_0140945 | Molecular function | histone H3K4 monomethyltransferase activity |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0046975 | Molecular function | histone H3K36 methyltransferase activity |
| Gene name | SETD4 |
| Protein name | SET domain containing 4 SET domain-containing protein 4 (EC 2.1.1.-) (EC 2.1.1.364) |
| Synonyms | C21orf27 C21orf18 |
| Description | FUNCTION: Histone-lysine N-methyltransferase that acts as a regulator of cell proliferation, cell differentiation and inflammatory response . Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro-inflammatory cytokines IL6 and TNF-alpha (By similarity). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation . Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). . |
| Accessions | Q9NVD3 C9JWV5 ENST00000424303.5 ENST00000399215.5 [Q9NVD3-1] ENST00000429161.5 A8MTS1 ENST00000446166.5 ENST00000442559.5 C9JYV0 ENST00000399207.5 [Q9NVD3-4] ENST00000399205.5 ENST00000332131.9 [Q9NVD3-1] C9JIU9 ENST00000443703.1 ENST00000399208.6 [Q9NVD3-4] C9JPA1 ENST00000399201.5 ENST00000399212.5 [Q9NVD3-3] C9J256 |
