CCL13 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCL13 at tissue level.

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007165Biological processsignal transduction
GO_0006935Biological processchemotaxis
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0007010Biological processcytoskeleton organization
GO_0007267Biological processcell-cell signaling
GO_0031640Biological processkilling of cells of another organism
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_0048245Biological processeosinophil chemotaxis
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0008360Biological processregulation of cell shape
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0008009Molecular functionchemokine activity
GO_0048020Molecular functionCCR chemokine receptor binding
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCL13
Protein nameC-C motif chemokine 13 (CK-beta-10) (Monocyte chemoattractant protein 4) (Monocyte chemotactic protein 4) (MCP-4) (NCC-1) (Small-inducible cytokine A13) [Cleaved into: C-C motif chemokine 13, long chain; C-C motif chemokine 13, medium chain; C-C motif chemokine 13, short chain]
CC-chemokine (Chemokine (C-C motif) ligand 13, isoform CRA_a)
C-C motif chemokine ligand 13
SynonymsNCC1
SCYA13
MCP4
hCG_29297
DescriptionFUNCTION: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.

AccessionsJ3QLQ9
ENST00000577681.1
Q99616
ENST00000225844.7
O95690