NDST1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015014Biological processheparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
GO_0035904Biological processaorta development
GO_0006954Biological processinflammatory response
GO_0008283Biological processcell population proliferation
GO_0030210Biological processheparin biosynthetic process
GO_0030900Biological processforebrain development
GO_0060976Biological processcoronary vasculature development
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0015015Biological processheparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0003279Biological processcardiac septum development
GO_0048703Biological processembryonic viscerocranium morphogenesis
GO_0048702Biological processembryonic neurocranium morphogenesis
GO_0030901Biological processmidbrain development
GO_0008543Biological processfibroblast growth factor receptor signaling pathway
GO_0007585Biological processrespiratory gaseous exchange by respiratory system
GO_0005794Cellular componentGolgi apparatus
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0000139Cellular componentGolgi membrane
GO_0102140Molecular functionheparan sulfate N-deacetylase activity
GO_0019213Molecular functiondeacetylase activity
GO_0015016Molecular function[heparan sulfate]-glucosamine N-sulfotransferase activity
GO_0050119Molecular functionN-acetylglucosamine deacetylase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNDST1
Protein nameN-deacetylase and N-sulfotransferase 1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (Glucosaminyl N-deacetylase/N-sulfotransferase 1) (NDST-1) (N-heparan sulfate sulfotransferase 1) (N-HSST 1) ([Heparan sulfate]-glucosamine N-sulfotransferase 1) (HSNST 1) [Includes: Heparan sulfate N-deacetylase 1 (EC 3.5.1.-); Heparan sulfate N-sulfotransferase 1 (EC 2.8.2.8)]
Alternative protein NDST1
SynonymsHSST1
HSST
DescriptionFUNCTION: [Isoform 1]: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate . Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis . Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan . .; FUNCTION: [Isoform 3]: Lacks both N-deacetylase and N-sulfotransferase activities. Acts as a dominant negative on isoform 1, likely by changing the composition of enzyme complexes responsible for elongation and modification of heparan sulfates. .

AccessionsENST00000519157.1
E5RGN9
L0R5C1
E5RG58
ENST00000261797.7 [P52848-1]
ENST00000523767.5 [P52848-3]
ENST00000518299.1
P52848
E5RG24
ENST00000522491.1