AIF1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	43 studies	78% ± 22%	Explore
classical monocyte	29 studies	86% ± 12%	Explore
conventional dendritic cell	29 studies	85% ± 14%	Explore
non-classical monocyte	26 studies	94% ± 9%	Explore
monocyte	25 studies	80% ± 22%	Explore
dendritic cell	23 studies	71% ± 24%	Explore
myeloid cell	15 studies	70% ± 22%	Explore
neutrophil	14 studies	62% ± 26%	Explore
plasmacytoid dendritic cell	14 studies	32% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	35% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	27% ± 8%	Explore
CD4-positive, alpha-beta T cell	8 studies	38% ± 24%	Explore
CD8-positive, alpha-beta T cell	8 studies	33% ± 25%	Explore
hematopoietic stem cell	8 studies	79% ± 16%	Explore
mononuclear phagocyte	7 studies	77% ± 25%	Explore
leukocyte	7 studies	53% ± 20%	Explore
microglial cell	7 studies	66% ± 31%	Explore
alveolar macrophage	6 studies	67% ± 24%	Explore
hematopoietic precursor cell	6 studies	73% ± 24%	Explore
T cell	6 studies	30% ± 16%	Explore
natural killer cell	6 studies	26% ± 12%	Explore
intermediate monocyte	6 studies	89% ± 10%	Explore
podocyte	4 studies	80% ± 14%	Explore
pro-B cell	4 studies	47% ± 10%	Explore
inflammatory macrophage	4 studies	73% ± 18%	Explore
mast cell	4 studies	43% ± 26%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	73% ± 27%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	22% ± 5%	Explore
Langerhans cell	3 studies	65% ± 35%	Explore
B cell	3 studies	28% ± 8%	Explore
plasmablast	3 studies	43% ± 16%	Explore
monocyte-derived dendritic cell	3 studies	85% ± 9%	Explore
common myeloid progenitor	3 studies	60% ± 33%	Explore
megakaryocyte	3 studies	49% ± 20%	Explore
tissue-resident macrophage	3 studies	69% ± 29%	Explore
granulocyte	3 studies	39% ± 13%	Explore
granulocyte monocyte progenitor cell	3 studies	64% ± 19%	Explore
erythrocyte	3 studies	27% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	36% ± 11%	Explore
lung	6 studies	30% ± 8%	Explore
bone marrow	5 studies	33% ± 9%	Explore
liver	5 studies	22% ± 7%	Explore
kidney	4 studies	22% ± 5%	Explore
brain	4 studies	41% ± 30%	Explore
placenta	3 studies	34% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	2132.30	577 / 578	94%	67.25	1081 / 1155
breast	96%	843.28	442 / 459	96%	60.87	1078 / 1118
kidney	99%	1536.49	88 / 89	90%	80.50	811 / 901
intestine	95%	737.40	914 / 966	73%	30.68	383 / 527
bladder	95%	617.81	20 / 21	71%	45.19	358 / 504
prostate	88%	584.53	215 / 245	78%	25.75	393 / 502
brain	63%	546.73	1663 / 2642	99%	120.61	696 / 705
adrenal gland	97%	917.80	251 / 258	63%	28.20	146 / 230
thymus	67%	333.97	439 / 653	85%	80.84	517 / 605
uterus	63%	271.38	107 / 170	85%	49.69	389 / 459
stomach	66%	343.24	237 / 359	78%	37.89	222 / 286
liver	51%	283.26	115 / 226	77%	37.38	313 / 406
ovary	43%	185.31	78 / 180	84%	43.69	363 / 430
esophagus	61%	322.19	878 / 1445	64%	22.33	117 / 183
skin	40%	151.76	720 / 1809	85%	67.20	399 / 472
pancreas	29%	124.88	94 / 328	93%	70.84	165 / 178
lymph node	0%	0	0 / 0	100%	257.07	29 / 29
spleen	100%	8566.15	241 / 241	0%	0	0 / 0
adipose	99%	1440.24	1192 / 1204	0%	0	0 / 0
peripheral blood	98%	5710.15	910 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	93%	64.45	42 / 45
blood vessel	88%	770.60	1174 / 1335	0%	0	0 / 0
heart	58%	282.24	498 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	49%	19.22	39 / 80
muscle	9%	29.17	73 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0032722	Biological process	positive regulation of chemokine production
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0010468	Biological process	regulation of gene expression
GO_0071673	Biological process	positive regulation of smooth muscle cell chemotaxis
GO_0006954	Biological process	inflammatory response
GO_0001774	Biological process	microglial cell activation
GO_0050921	Biological process	positive regulation of chemotaxis
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0090026	Biological process	positive regulation of monocyte chemotaxis
GO_0030041	Biological process	actin filament polymerization
GO_0097178	Biological process	ruffle assembly
GO_0090271	Biological process	positive regulation of fibroblast growth factor production
GO_0006911	Biological process	phagocytosis, engulfment
GO_0071346	Biological process	cellular response to type II interferon
GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_0051017	Biological process	actin filament bundle assembly
GO_0034599	Biological process	cellular response to oxidative stress
GO_0071677	Biological process	positive regulation of mononuclear cell migration
GO_0030335	Biological process	positive regulation of cell migration
GO_0051764	Biological process	actin crosslink formation
GO_0048662	Biological process	negative regulation of smooth muscle cell proliferation
GO_0016601	Biological process	Rac protein signal transduction
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0030046	Biological process	parallel actin filament bundle assembly
GO_0071672	Biological process	negative regulation of smooth muscle cell chemotaxis
GO_2000406	Biological process	positive regulation of T cell migration
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0001726	Cellular component	ruffle
GO_0032587	Cellular component	ruffle membrane
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005884	Cellular component	actin filament
GO_0005829	Cellular component	cytosol
GO_0001891	Cellular component	phagocytic cup
GO_0005737	Cellular component	cytoplasm
GO_0097386	Cellular component	glial cell projection
GO_0030027	Cellular component	lamellipodium
GO_0005634	Cellular component	nucleus
GO_0051015	Molecular function	actin filament binding
GO_0005509	Molecular function	calcium ion binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	AIF1
Protein name	Allograft inflammatory factor 1 (AIF-1) (Ionized calcium-binding adapter molecule 1) (Protein G1) Allograft inflammatory factor 1
Synonyms	hCG_43680 G1 IBA1
Description	FUNCTION: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. .
Accessions	ENST00000454573.6 ENST00000440907.6 [P55008-1] ENST00000425748.6 [P55008-1] ENST00000437985.6 ENST00000376049.4 [P55008-2] ENST00000376059.8 [P55008-1] Q5STX8 ENST00000419376.2 [P55008-2] ENST00000417200.6 ENST00000383474.8 [P55008-1] ENST00000415830.2 [P55008-2] ENST00000337917.11 ENST00000383473.4 [P55008-2] ENST00000414149.6 [P55008-1] ENST00000454372.6 Q4V347 ENST00000413349.6 [P55008-1] ENST00000416422.2 [P55008-2] ENST00000412407.6 P55008 I3WTX1 ENST00000424944.2 [P55008-2]

AIF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review