ELF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0030198Biological processextracellular matrix organization
GO_0060056Biological processmammary gland involution
GO_0030154Biological processcell differentiation
GO_0001824Biological processblastocyst development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameELF3
Protein nameE74-like ETS transcription factor 3 isoform 12
E74-like ETS transcription factor 3 isoform 16
E74-like ETS transcription factor 3 isoform 13
E74-like ETS transcription factor 3 isoform 17
E74 like ETS transcription factor 3
E74-like ETS transcription factor 3 isoform 15
E74-like ETS transcription factor 3 isoform 19
E74-like ETS transcription factor 3 isoform 3 (E74-like ETS transcription factor 3 isoform 6)
E74-like ETS transcription factor 3 isoform 18
E74-like ETS transcription factor 3 isoform 5
E74-like ETS transcription factor 3 isoform 2
E74-like ETS transcription factor 3 isoform 20
E74-like ETS transcription factor 3 isoform 11
E74-like ETS transcription factor 3 isoform 14
E74-like ETS transcription factor 3 isoform 7
E74-like ETS transcription factor 3 isoform 8
ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)
E74-like ETS transcription factor 3 isoform 9
E74-like ETS transcription factor 3 isoform 4
E74-like ETS transcription factor 3 isoform 10
SynonymsESX
JEN
ERT
DescriptionFUNCTION: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). .

AccessionsA0A8E8V1S5
A0A8E8R7S3
A0A8E8V2N5
A0A8E8V181
ENST00000446188.1
A0A8E8R9U5
A0A8E8RB67
A0A8E8R7T2
ENST00000367284.10 [P78545-1]
A0A8E8R9T1
A0A8E8V174
ENST00000367283.7 [P78545-1]
A0A8E8V1H0
A0A8E8V1G0
A0A8E8R9M4
A0A8E8V2S2
A0A8E8R9N5
Q5SR36
ENST00000359651.7 [P78545-1]
P78545
A0A8E8R951
A0A8E8V1T0
A0A8E8R9M5
A0A8E8R776