CHST1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CHST1 at tissue level.

III. Associated gene sets

GO_0042339Biological processkeratan sulfate metabolic process
GO_0006044Biological processN-acetylglucosamine metabolic process
GO_0006954Biological processinflammatory response
GO_0005976Biological processpolysaccharide metabolic process
GO_0006790Biological processsulfur compound metabolic process
GO_0018146Biological processkeratan sulfate biosynthetic process
GO_0006012Biological processgalactose metabolic process
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0016020Cellular componentmembrane
GO_0045130Molecular functionkeratan sulfotransferase activity
GO_0008146Molecular functionsulfotransferase activity
GO_0001517Molecular functionN-acetylglucosamine 6-O-sulfotransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCHST1
Protein nameCarbohydrate sulfotransferase 1 (Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1) (GST-1) (Keratan sulfate Gal-6 sulfotransferase) (KS6ST) (KSGal6ST) (KSST) (EC 2.8.2.21)
Synonyms
DescriptionFUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer . Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer . Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (By similarity). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking . Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures . .

AccessionsO43916
ENST00000308064.7