HDAC5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0090051Biological processnegative regulation of cell migration involved in sprouting angiogenesis
GO_0006954Biological processinflammatory response
GO_0032869Biological processcellular response to insulin stimulus
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0010830Biological processregulation of myotube differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0014823Biological processresponse to activity
GO_0043393Biological processregulation of protein binding
GO_0030182Biological processneuron differentiation
GO_0010832Biological processnegative regulation of myotube differentiation
GO_0042220Biological processresponse to cocaine
GO_0042113Biological processB cell activation
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030183Biological processB cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000118Cellular componenthistone deacetylase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0004407Molecular functionhistone deacetylase activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0042802Molecular functionidentical protein binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameHDAC5
Protein namehistone deacetylase (EC 3.5.1.98)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Histone deacetylase 5
SynonymsKIAA0600
DescriptionFUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Serves as a corepressor of RARA and causes its deacetylation . In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response . .

AccessionsENST00000588261.1
ENST00000587135.1
Q9UQL6
ENST00000591714.5
ENST00000682912.1 [Q9UQL6-1]
K7EJL4
K7EJZ7
ENST00000225983.10 [Q9UQL6-3]
ENST00000588703.5
K7EJL6
ENST00000586802.5 [Q9UQL6-1]
K7ES01
ENST00000336057.9 [Q9UQL6-2]