TCIRG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0043029Biological processT cell homeostasis
GO_0010272Biological processresponse to silver ion
GO_0010468Biological processregulation of gene expression
GO_0050796Biological processregulation of insulin secretion
GO_0006954Biological processinflammatory response
GO_0031529Biological processruffle organization
GO_0030316Biological processosteoclast differentiation
GO_0045667Biological processregulation of osteoblast differentiation
GO_0000045Biological processautophagosome assembly
GO_0090383Biological processphagosome acidification
GO_0007042Biological processlysosomal lumen acidification
GO_1902600Biological processproton transmembrane transport
GO_0035711Biological processT-helper 1 cell activation
GO_0016236Biological processmacroautophagy
GO_0060041Biological processretina development in camera-type eye
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0033365Biological processprotein localization to organelle
GO_0006968Biological processcellular defense response
GO_0007039Biological processprotein catabolic process in the vacuole
GO_0097188Biological processdentin mineralization
GO_0061484Biological processhematopoietic stem cell homeostasis
GO_0021554Biological processoptic nerve development
GO_0030217Biological processT cell differentiation
GO_0044691Biological processtooth eruption
GO_0035709Biological processmemory T cell activation
GO_0071345Biological processcellular response to cytokine stimulus
GO_0045851Biological processpH reduction
GO_0016064Biological processimmunoglobulin mediated immune response
GO_0002158Biological processosteoclast proliferation
GO_0045453Biological processbone resorption
GO_0007035Biological processvacuolar acidification
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0010155Biological processregulation of proton transport
GO_0070166Biological processenamel mineralization
GO_0010467Biological processgene expression
GO_0001503Biological processossification
GO_0051650Biological processestablishment of vesicle localization
GO_0030183Biological processB cell differentiation
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0033176Cellular componentproton-transporting V-type ATPase complex
GO_0005770Cellular componentlate endosome
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0000220Cellular componentvacuolar proton-transporting V-type ATPase, V0 domain
GO_0010008Cellular componentendosome membrane
GO_0016471Cellular componentvacuolar proton-transporting V-type ATPase complex
GO_0005765Cellular componentlysosomal membrane
GO_0005634Cellular componentnucleus
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTCIRG1
Protein nameV-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3)
V-type proton ATPase subunit a
T-cell immune regulator 1 transcript variant 7
T-cell immune regulator 1 transcript variant 6
T-cell immune regulator 1 transcript variant 8
SynonymsATP6V0A3
ATP6N1C
DescriptionFUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Seems to be directly involved in T-cell activation . .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

AccessionsENST00000524598.5
A0A8V8TM28
ENST00000265686.8 [Q13488-1]
ENST00000698256.1
Q6QBN6
E9PM12
H0YEL3
A0A8V8TNB5
ENST00000530063.1
ENST00000528981.5
ENST00000532635.5 [Q13488-2]
E9PNA6
Q6QBN7
Q6QBN5
Q13488
Q64F87
ENST00000529657.1
Q6QBN4
ENST00000698255.1
A0A8V8TN16
H0YCE3
Q8TCH1
E9PMC5
ENST00000529364.1
ENST00000534673.5
ENST00000698254.1
Q6QBN8