FUT7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FUT7 at tissue level.

III. Associated gene sets

GO_0002522Biological processleukocyte migration involved in immune response
GO_0006954Biological processinflammatory response
GO_0009312Biological processoligosaccharide biosynthetic process
GO_1903037Biological processregulation of leukocyte cell-cell adhesion
GO_0022407Biological processregulation of cell-cell adhesion
GO_0036065Biological processfucosylation
GO_0097022Biological processlymphocyte migration into lymph node
GO_0002523Biological processleukocyte migration involved in inflammatory response
GO_0006672Biological processceramide metabolic process
GO_0006486Biological processprotein glycosylation
GO_0045785Biological processpositive regulation of cell adhesion
GO_0042355Biological processL-fucose catabolic process
GO_1903236Biological processregulation of leukocyte tethering or rolling
GO_1903238Biological processpositive regulation of leukocyte tethering or rolling
GO_2000389Biological processregulation of neutrophil extravasation
GO_1902624Biological processpositive regulation of neutrophil migration
GO_0001807Biological processregulation of type IV hypersensitivity
GO_0002361Biological processCD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO_1904996Biological processpositive regulation of leukocyte adhesion to vascular endothelial cell
GO_0072678Biological processT cell migration
GO_0046626Biological processregulation of insulin receptor signaling pathway
GO_0022409Biological processpositive regulation of cell-cell adhesion
GO_0007566Biological processembryo implantation
GO_0060353Biological processregulation of cell adhesion molecule production
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0032580Cellular componentGolgi cisterna membrane
GO_0008417Molecular functionfucosyltransferase activity
GO_0017083Molecular function4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
GO_0046920Molecular functionalpha-(1->3)-fucosyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFUT7
Protein nameAlpha-(1,3)-fucosyltransferase 7 (EC 2.4.1.-) (Fucosyltransferase 7) (Fucosyltransferase VII) (Fuc-TVII) (FucT-VII) (Galactoside 3-L-fucosyltransferase) (Selectin ligand synthase)
Synonyms
DescriptionFUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein or a glycolipid-linked sialopolylactosamines chain through an alpha-1,3 glycosidic linkage and participates in the final fucosylation step in the biosynthesis of the sialyl Lewis X (sLe(x)), a carbohydrate involved in cell and matrix adhesion during leukocyte trafficking and fertilization . In vitro, also synthesizes sialyl-dimeric-Lex structures, from VIM-2 structures and both di-fucosylated and trifucosylated structures from mono-fucosylated precursors . However does not catalyze alpha 1-3 fucosylation when an internal alpha 1-3 fucosylation is present in polylactosamine chain and the fucosylation rate of the internal GlcNAc residues is reduced once fucose has been added to the distal GlcNAc . Also catalyzes the transfer of a fucose from GDP-beta-fucose to the 6-sulfated a(2,3)sialylated substrate to produce 6-sulfo sLex mediating significant L-selectin-dependent cell adhesion . Through sialyl-Lewis(x) biosynthesis, can control SELE- and SELP-mediated cell adhesion with leukocytes and allows leukocytes tethering and rolling along the endothelial tissue thereby enabling the leukocytes to accumulate at a site of inflammation . May enhance embryo implantation through sialyl Lewis X (sLeX)-mediated adhesion of embryo cells to endometrium . May affect insulin signaling by up-regulating the phosphorylation and expression of some signaling molecules involved in the insulin-signaling pathway through SLe(x) which is present on the glycans of the INSRR alpha subunit . .

AccessionsQ11130
ENST00000314412.7