MFHAS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0034136Biological processnegative regulation of toll-like receptor 2 signaling pathway
GO_0045087Biological processinnate immune response
GO_0046330Biological processpositive regulation of JNK cascade
GO_0007165Biological processsignal transduction
GO_0034144Biological processnegative regulation of toll-like receptor 4 signaling pathway
GO_0043030Biological processregulation of macrophage activation
GO_1900745Biological processpositive regulation of p38MAPK cascade
GO_0034137Biological processpositive regulation of toll-like receptor 2 signaling pathway
GO_0030218Biological processerythrocyte differentiation
GO_0050728Biological processnegative regulation of inflammatory response
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_1900181Biological processnegative regulation of protein localization to nucleus
GO_0034121Biological processregulation of toll-like receptor signaling pathway
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0035308Biological processnegative regulation of protein dephosphorylation
GO_0005856Cellular componentcytoskeleton
GO_0005739Cellular componentmitochondrion
GO_0005764Cellular componentlysosome
GO_0005737Cellular componentcytoplasm
GO_0051721Molecular functionprotein phosphatase 2A binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMFHAS1
Protein nameMalignant fibrous histiocytoma-amplified sequence 1 (Malignant fibrous histiocytoma-amplified sequence with leucine-rich tandem repeats 1)
Alternative protein MFHAS1
SynonymsMASL1
DescriptionFUNCTION: Probable GTP-binding protein . Functions in innate immunity and more specifically the inflammatory response as a regulator of the Toll-like receptor TLR2 and TLR4 signaling pathways . Negatively regulates the part of the TLR4 signaling pathway that leads to the activation of the transcription factor AP-1. By retaining the phosphatase complex PP2A into the cytoplasm, prevents the dephosphorylation of the AP-1 subunit JUN which is required for proper activation of the transcription factor . Both inhibits and activates the TLR2-dependent signaling pathway . Positively regulates the TLR2 signaling pathway to activate specifically the downstream p38 and JNK MAP kinases and promote the polarization of macrophages toward the pro-inflammatory M1 phenotype . It may also play a role in the regulation of inflammation induced by high glucose through the PKB/AKT signaling pathway . Also involved in erythrocyte differentiation through activation of the ERK1/ERK2 signaling pathway . .

AccessionsQ9Y4C4
L8E7L4
ENST00000276282.7