PLA2G2A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLA2G2A at tissue level.

III. Associated gene sets

GO_0010744Biological processpositive regulation of macrophage derived foam cell differentiation
GO_0036335Biological processintestinal stem cell homeostasis
GO_0006954Biological processinflammatory response
GO_0016042Biological processlipid catabolic process
GO_0031640Biological processkilling of cells of another organism
GO_0034374Biological processlow-density lipoprotein particle remodeling
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0046473Biological processphosphatidic acid metabolic process
GO_0006644Biological processphospholipid metabolic process
GO_0050729Biological processpositive regulation of inflammatory response
GO_0046337Biological processphosphatidylethanolamine metabolic process
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_1902563Biological processregulation of neutrophil activation
GO_0050482Biological processarachidonic acid secretion
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0070062Cellular componentextracellular exosome
GO_0005783Cellular componentendoplasmic reticulum
GO_0005741Cellular componentmitochondrial outer membrane
GO_0030141Cellular componentsecretory granule
GO_0047498Molecular functioncalcium-dependent phospholipase A2 activity
GO_0005543Molecular functionphospholipid binding
GO_0004623Molecular functionphospholipase A2 activity
GO_0005509Molecular functioncalcium ion binding

IV. Literature review

[source]
Gene namePLA2G2A
Protein namePhospholipase A2 (EC 3.1.1.4)
Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Non-pancreatic secretory phospholipase A2) (NPS-PLA2) (Phosphatidylcholine 2-acylhydrolase 2A)
Phospholipase A2, membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A)
SynonymsPLA2L
RASF-A
PLA2B
DescriptionFUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids with implications in host antimicrobial defense, inflammatory response and tissue regeneration . Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines . Contributes to lipid remodeling of cellular membranes and generation of lipid mediators involved in pathogen clearance. Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing phospholipids of the bacterial membrane . Upon sterile inflammation, targets membrane phospholipids of extracellular mitochondria released from activated platelets, generating free unsaturated fatty acids such as arachidonate that is used by neighboring leukocytes to synthesize inflammatory eicosanoids such as leukotrienes. Simultaneously, by compromising mitochondrial membrane integrity, promotes the release in circulation of potent damage-associated molecular pattern molecules that activate the innate immune response . Plays a stem cell regulator role in the intestinal crypt. Within intracellular compartment mediates Paneth cell differentiation and its stem cell supporting functions by inhibiting Wnt signaling pathway in intestinal stem cell (ICS). Secreted in the intestinal lumen upon inflammation, acts in an autocrine way and promotes prostaglandin E2 synthesis that stimulates Wnt signaling pathway in ICS cells and tissue regeneration (By similarity). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines . Independent of its catalytic activity, acts as a ligand for integrins . Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 . Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 . Induces cell proliferation in an integrin-dependent manner . .

AccessionsQ8NI47
ENST00000375111.7
ENST00000400520.8
P14555
A0A3B3IRX2
ENST00000482011.3
ENST00000649436.1