Name | Number of supported studies | Average coverage | |
---|---|---|---|
plasmacytoid dendritic cell | 19 studies | 47% ± 15% | |
endothelial cell | 9 studies | 23% ± 5% | |
macrophage | 8 studies | 21% ± 6% | |
natural killer cell | 6 studies | 21% ± 8% | |
classical monocyte | 6 studies | 28% ± 10% | |
fibroblast | 6 studies | 20% ± 3% | |
type I pneumocyte | 6 studies | 19% ± 3% | |
monocyte | 5 studies | 21% ± 2% | |
smooth muscle cell | 5 studies | 20% ± 2% | |
myeloid cell | 5 studies | 28% ± 11% | |
plasma cell | 5 studies | 29% ± 9% | |
epithelial cell | 5 studies | 34% ± 14% | |
cardiac muscle cell | 5 studies | 30% ± 6% | |
pericyte | 5 studies | 20% ± 2% | |
type II pneumocyte | 5 studies | 20% ± 3% | |
non-classical monocyte | 4 studies | 32% ± 17% | |
B cell | 4 studies | 19% ± 3% | |
hematopoietic precursor cell | 4 studies | 25% ± 6% | |
mature NK T cell | 4 studies | 19% ± 2% | |
goblet cell | 4 studies | 24% ± 9% | |
T cell | 3 studies | 26% ± 10% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 27% ± 4% | |
CD8-positive, alpha-beta T cell | 3 studies | 28% ± 11% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 30% ± 11% | |
squamous epithelial cell | 3 studies | 33% ± 20% | |
retinal cone cell | 3 studies | 19% ± 3% | |
lymphocyte | 3 studies | 23% ± 5% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 24% ± 5% | |
basal cell | 3 studies | 24% ± 6% | |
gamma-delta T cell | 3 studies | 23% ± 5% | |
dendritic cell | 3 studies | 36% ± 25% | |
leukocyte | 3 studies | 21% ± 1% | |
endothelial cell of vascular tree | 3 studies | 20% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6866.99 | 1445 / 1445 | 100% | 108.32 | 183 / 183 |
kidney | 100% | 9510.12 | 89 / 89 | 100% | 123.26 | 901 / 901 |
lung | 100% | 11559.69 | 578 / 578 | 100% | 136.91 | 1155 / 1155 |
stomach | 100% | 7577.38 | 359 / 359 | 100% | 97.90 | 286 / 286 |
uterus | 100% | 7709.29 | 170 / 170 | 100% | 132.10 | 459 / 459 |
thymus | 100% | 7478.32 | 652 / 653 | 100% | 124.61 | 605 / 605 |
ovary | 100% | 6287.13 | 180 / 180 | 100% | 77.59 | 429 / 430 |
skin | 100% | 7438.26 | 1808 / 1809 | 100% | 120.15 | 471 / 472 |
breast | 100% | 7749.48 | 459 / 459 | 100% | 232.02 | 1115 / 1118 |
pancreas | 100% | 4325.84 | 327 / 328 | 100% | 129.80 | 178 / 178 |
intestine | 100% | 7488.18 | 966 / 966 | 100% | 105.07 | 525 / 527 |
prostate | 100% | 6577.60 | 245 / 245 | 100% | 64.16 | 500 / 502 |
bladder | 100% | 7191.14 | 21 / 21 | 99% | 102.01 | 501 / 504 |
liver | 100% | 4977.64 | 226 / 226 | 99% | 86.89 | 402 / 406 |
adrenal gland | 100% | 10481.49 | 258 / 258 | 97% | 62.82 | 223 / 230 |
brain | 91% | 2701.26 | 2415 / 2642 | 100% | 82.29 | 703 / 705 |
adipose | 100% | 7898.47 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 78.71 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 197.79 | 29 / 29 |
muscle | 100% | 15883.86 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 11001.54 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 155.23 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 99.60 | 1 / 1 |
blood vessel | 100% | 8364.40 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 100% | 15862.52 | 857 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 11493.48 | 922 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0044351 | Biological process | macropinocytosis |
GO_0002224 | Biological process | toll-like receptor signaling pathway |
GO_0018105 | Biological process | peptidyl-serine phosphorylation |
GO_0032680 | Biological process | regulation of tumor necrosis factor production |
GO_0006954 | Biological process | inflammatory response |
GO_0043488 | Biological process | regulation of mRNA stability |
GO_0000165 | Biological process | MAPK cascade |
GO_0034097 | Biological process | response to cytokine |
GO_0006974 | Biological process | DNA damage response |
GO_0048839 | Biological process | inner ear development |
GO_0010803 | Biological process | regulation of tumor necrosis factor-mediated signaling pathway |
GO_1900034 | Biological process | regulation of cellular response to heat |
GO_0006691 | Biological process | leukotriene metabolic process |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0070935 | Biological process | 3'-UTR-mediated mRNA stabilization |
GO_0060907 | Biological process | positive regulation of macrophage cytokine production |
GO_0048010 | Biological process | vascular endothelial growth factor receptor signaling pathway |
GO_0006468 | Biological process | protein phosphorylation |
GO_0046777 | Biological process | protein autophosphorylation |
GO_0032675 | Biological process | regulation of interleukin-6 production |
GO_0038066 | Biological process | p38MAPK cascade |
GO_0035924 | Biological process | cellular response to vascular endothelial growth factor stimulus |
GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
GO_0032496 | Biological process | response to lipopolysaccharide |
GO_0005813 | Cellular component | centrosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0009931 | Molecular function | calcium-dependent protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0004672 | Molecular function | protein kinase activity |
GO_0051019 | Molecular function | mitogen-activated protein kinase binding |
GO_0005524 | Molecular function | ATP binding |
GO_0004683 | Molecular function | calmodulin-dependent protein kinase activity |
GO_0005516 | Molecular function | calmodulin binding |
GO_0005515 | Molecular function | protein binding |
Gene name | MAPKAPK2 |
Protein name | MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1) |
Synonyms | |
Description | FUNCTION: Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities . Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites . Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. . |
Accessions | P49137 ENST00000294981.8 [P49137-2] ENST00000367103.4 [P49137-1] |