MAPKAPK2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044351Biological processmacropinocytosis
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0032680Biological processregulation of tumor necrosis factor production
GO_0006954Biological processinflammatory response
GO_0043488Biological processregulation of mRNA stability
GO_0000165Biological processMAPK cascade
GO_0034097Biological processresponse to cytokine
GO_0006974Biological processDNA damage response
GO_0048839Biological processinner ear development
GO_0010803Biological processregulation of tumor necrosis factor-mediated signaling pathway
GO_1900034Biological processregulation of cellular response to heat
GO_0006691Biological processleukotriene metabolic process
GO_0035556Biological processintracellular signal transduction
GO_0070935Biological process3'-UTR-mediated mRNA stabilization
GO_0060907Biological processpositive regulation of macrophage cytokine production
GO_0048010Biological processvascular endothelial growth factor receptor signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0032675Biological processregulation of interleukin-6 production
GO_0038066Biological processp38MAPK cascade
GO_0035924Biological processcellular response to vascular endothelial growth factor stimulus
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0032496Biological processresponse to lipopolysaccharide
GO_0005813Cellular componentcentrosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0009931Molecular functioncalcium-dependent protein serine/threonine kinase activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0005524Molecular functionATP binding
GO_0004683Molecular functioncalmodulin-dependent protein kinase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAPKAPK2
Protein nameMAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)
Synonyms
DescriptionFUNCTION: Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Phosphorylates HSF1; leading to the interaction with HSP90 proteins and inhibiting HSF1 homotrimerization, DNA-binding and transactivation activities . Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to the dissociation of HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impairment of their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to the regulation of the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity, leading to inhibition of dependent degradation of ARE-containing transcripts. Phosphorylates CEP131 in response to cellular stress induced by ultraviolet irradiation which promotes binding of CEP131 to 14-3-3 proteins and inhibits formation of novel centriolar satellites . Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilization of GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. .

AccessionsP49137
ENST00000294981.8 [P49137-2]
ENST00000367103.4 [P49137-1]