I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 14 studies | 25% ± 7% | |
| fibroblast | 12 studies | 22% ± 6% | |
| smooth muscle cell | 5 studies | 26% ± 6% | |
| platelet | 4 studies | 19% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 14 studies | 25% ± 7% | |
| fibroblast | 12 studies | 22% ± 6% | |
| smooth muscle cell | 5 studies | 26% ± 6% | |
| platelet | 4 studies | 19% ± 5% |
Insufficient scRNA-seq data for expression of PTGIR at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 4771.57 | 577 / 578 | 95% | 4.25 | 1095 / 1155 |
| thymus | 99% | 1647.26 | 647 / 653 | 82% | 3.27 | 496 / 605 |
| adrenal gland | 89% | 551.42 | 229 / 258 | 83% | 9.14 | 190 / 230 |
| kidney | 92% | 1180.12 | 82 / 89 | 76% | 4.36 | 683 / 901 |
| breast | 65% | 440.08 | 298 / 459 | 91% | 3.02 | 1020 / 1118 |
| pancreas | 51% | 243.07 | 166 / 328 | 96% | 8.10 | 170 / 178 |
| liver | 81% | 415.11 | 182 / 226 | 64% | 2.39 | 258 / 406 |
| intestine | 66% | 405.57 | 642 / 966 | 74% | 2.39 | 392 / 527 |
| stomach | 56% | 469.69 | 202 / 359 | 82% | 3.15 | 235 / 286 |
| skin | 71% | 585.11 | 1284 / 1809 | 66% | 1.85 | 313 / 472 |
| esophagus | 57% | 376.25 | 830 / 1445 | 77% | 2.13 | 140 / 183 |
| uterus | 64% | 398.54 | 108 / 170 | 67% | 1.90 | 309 / 459 |
| bladder | 57% | 530.43 | 12 / 21 | 66% | 1.99 | 332 / 504 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 26.61 | 29 / 29 |
| blood vessel | 100% | 3881.86 | 1332 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 99% | 951.52 | 238 / 241 | 0% | 0 | 0 / 0 |
| ovary | 24% | 155.87 | 43 / 180 | 67% | 1.98 | 289 / 430 |
| heart | 91% | 1234.38 | 782 / 861 | 0% | 0 | 0 / 0 |
| adipose | 89% | 982.71 | 1077 / 1204 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 76% | 4.46 | 34 / 45 |
| peripheral blood | 67% | 449.61 | 624 / 929 | 0% | 0 | 0 / 0 |
| prostate | 24% | 176.23 | 60 / 245 | 18% | 0.29 | 89 / 502 |
| brain | 1% | 3.00 | 23 / 2642 | 24% | 0.53 | 171 / 705 |
| muscle | 18% | 92.26 | 148 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.06 | 4 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010642 | Biological process | negative regulation of platelet-derived growth factor receptor signaling pathway |
| GO_0007204 | Biological process | positive regulation of cytosolic calcium ion concentration |
| GO_0006954 | Biological process | inflammatory response |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0048662 | Biological process | negative regulation of smooth muscle cell proliferation |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0007187 | Biological process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016501 | Molecular function | prostacyclin receptor activity |
| GO_0005085 | Molecular function | guanyl-nucleotide exchange factor activity |
| Gene name | PTGIR |
| Protein name | Prostacyclin receptor (Prostaglandin I2 receptor) (PGI receptor) (PGI2 receptor) (Prostanoid IP receptor) Prostaglandin I2 (Prostacyclin) receptor (IP) Prostaglandin I2 receptor Prostaglandin I2 (Prostacyclin) receptor (IP), isoform CRA_b (Prostaglandin I2 receptor) |
| Synonyms | PRIPR hCG_1777582 |
| Description | FUNCTION: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. |
| Accessions | A0A0B4J2A7 ENST00000291294.7 M0QXV5 ENST00000594275.1 ENST00000597185.1 P43119 ENST00000596260.1 Q2YD89 ENST00000598865.5 M0QZW0 M0QZI2 |
