NKG7 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	50 studies	88% ± 19%	Explore
CD8-positive, alpha-beta T cell	39 studies	69% ± 20%	Explore
T cell	29 studies	45% ± 19%	Explore
mature NK T cell	23 studies	89% ± 14%	Explore
gamma-delta T cell	21 studies	73% ± 22%	Explore
CD16-negative, CD56-bright natural killer cell, human	17 studies	91% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	17 studies	93% ± 17%	Explore
mucosal invariant T cell	16 studies	75% ± 20%	Explore
classical monocyte	14 studies	26% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	67% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	72% ± 26%	Explore
non-classical monocyte	12 studies	23% ± 6%	Explore
CD4-positive, alpha-beta T cell	11 studies	29% ± 22%	Explore
monocyte	9 studies	36% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	82% ± 26%	Explore
plasmacytoid dendritic cell	8 studies	29% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	53% ± 25%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	26% ± 10%	Explore
innate lymphoid cell	7 studies	59% ± 28%	Explore
conventional dendritic cell	6 studies	37% ± 15%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	62% ± 28%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	56% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	94% ± 4%	Explore
exhausted T cell	5 studies	92% ± 4%	Explore
platelet	5 studies	33% ± 15%	Explore
leukocyte	5 studies	39% ± 30%	Explore
myeloid cell	5 studies	37% ± 14%	Explore
mast cell	5 studies	37% ± 19%	Explore
dendritic cell	4 studies	25% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	41% ± 21%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	23% ± 5%	Explore
plasmablast	3 studies	49% ± 18%	Explore
erythrocyte	3 studies	40% ± 4%	Explore
common myeloid progenitor	3 studies	30% ± 10%	Explore
hematopoietic stem cell	3 studies	21% ± 3%	Explore
granulocyte	3 studies	37% ± 1%	Explore
plasma cell	3 studies	40% ± 9%	Explore
T-helper 1 cell	3 studies	28% ± 7%	Explore
hematopoietic precursor cell	3 studies	53% ± 3%	Explore
double negative thymocyte	3 studies	58% ± 31%	Explore
group 3 innate lymphoid cell	3 studies	46% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	21 studies	35% ± 8%	Explore
lung	6 studies	22% ± 5%	Explore
bone marrow	4 studies	35% ± 13%	Explore
liver	4 studies	33% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	1498.56	578 / 578	87%	40.20	1002 / 1155
liver	96%	370.96	216 / 226	65%	24.71	262 / 406
breast	85%	223.76	391 / 459	65%	27.59	722 / 1118
kidney	69%	164.10	61 / 89	79%	72.97	711 / 901
thymus	80%	210.09	522 / 653	63%	27.71	381 / 605
uterus	60%	112.48	102 / 170	75%	49.93	344 / 459
stomach	57%	106.49	203 / 359	69%	37.47	196 / 286
bladder	67%	163.52	14 / 21	58%	26.65	291 / 504
prostate	77%	151.16	189 / 245	42%	7.96	213 / 502
intestine	54%	144.49	517 / 966	66%	23.79	347 / 527
lymph node	0%	0	0 / 0	100%	636.92	29 / 29
spleen	100%	4672.45	241 / 241	0%	0	0 / 0
peripheral blood	99%	17768.50	921 / 929	0%	0	0 / 0
esophagus	37%	56.17	531 / 1445	61%	18.80	111 / 183
adipose	93%	322.25	1122 / 1204	0%	0	0 / 0
ovary	22%	30.04	39 / 180	69%	26.18	297 / 430
tonsil	0%	0	0 / 0	89%	97.65	40 / 45
skin	13%	15.57	234 / 1809	75%	89.60	355 / 472
pancreas	12%	14.71	38 / 328	70%	20.74	124 / 178
adrenal gland	47%	57.74	122 / 258	32%	7.02	73 / 230
heart	55%	96.49	471 / 861	0%	0	0 / 0
blood vessel	50%	101.30	673 / 1335	0%	0	0 / 0
brain	23%	29.69	606 / 2642	18%	5.16	127 / 705
eye	0%	0	0 / 0	35%	21.72	28 / 80
muscle	19%	23.10	156 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0043320	Biological process	natural killer cell degranulation
GO_0002420	Biological process	natural killer cell mediated cytotoxicity directed against tumor cell target
GO_0031640	Biological process	killing of cells of another organism
GO_0140507	Biological process	granzyme-mediated programmed cell death signaling pathway
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0006954	Biological process	inflammatory response
GO_0035710	Biological process	CD4-positive, alpha-beta T cell activation
GO_0042832	Biological process	defense response to protozoan
GO_0042267	Biological process	natural killer cell mediated cytotoxicity
GO_0044194	Cellular component	cytolytic granule
GO_0101004	Cellular component	cytolytic granule membrane
GO_0005886	Cellular component	plasma membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NKG7
Protein name	Natural killer cell granule protein 7 (Natural killer cell group 7 sequence, isoform CRA_b) Protein NKG7 (G-CSF-induced gene 1 protein) (GIG-1 protein) (Granule membrane protein of 17 kDa) (GMP-17) (Natural killer cell protein 7) (p15-TIA-1) Natural killer cell granule protein 7
Synonyms	hCG_91952 GIG1
Description	FUNCTION: Regulates cytotoxic granule exocytosis in effector lymphocytes, thus acting as a critical mediator of inflammation in a broad range of infectious and non-infectious diseases (By similarity). Essential for cytotoxic degranulation of natural killer (NK) cells and CD8(+) T-cells and for the activation of CD4(+) T-cells following infection (By similarity). Plays a critical role in CD8(+) T-cell and NK cell-mediated cytolysis of target cells and contributes to the cytolytic activity via the perforin/granzyme pathway by enhancing exocytosis of LAMP1-carrying lytic granules (By similarity). Contributes to NK cell-mediated control of cancer metastasis (By similarity). .
Accessions	ENST00000595157.1 M0R3G3 A0A0B4J2A6 ENST00000221978.10 M0R0D6 ENST00000593572.5 M0QXT6 ENST00000595217.1 Q16617 ENST00000600427.5

NKG7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review