PRKCZ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030010Biological processestablishment of cell polarity
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0072659Biological processprotein localization to plasma membrane
GO_0006954Biological processinflammatory response
GO_0051899Biological processmembrane depolarization
GO_0032869Biological processcellular response to insulin stimulus
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0007616Biological processlong-term memory
GO_0007165Biological processsignal transduction
GO_0032736Biological processpositive regulation of interleukin-13 production
GO_0031333Biological processnegative regulation of protein-containing complex assembly
GO_0001954Biological processpositive regulation of cell-matrix adhesion
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0060291Biological processlong-term synaptic potentiation
GO_2000463Biological processpositive regulation of excitatory postsynaptic potential
GO_2000553Biological processpositive regulation of T-helper 2 cell cytokine production
GO_0050732Biological processnegative regulation of peptidyl-tyrosine phosphorylation
GO_0045197Biological processestablishment or maintenance of epithelial cell apical/basal polarity
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0060081Biological processmembrane hyperpolarization
GO_0032754Biological processpositive regulation of interleukin-5 production
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0051222Biological processpositive regulation of protein transport
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0046628Biological processpositive regulation of insulin receptor signaling pathway
GO_0098696Biological processregulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO_0008284Biological processpositive regulation of cell population proliferation
GO_1990138Biological processneuron projection extension
GO_0070528Biological processprotein kinase C signaling
GO_0006468Biological processprotein phosphorylation
GO_0070374Biological processpositive regulation of ERK1 and ERK2 cascade
GO_0016477Biological processcell migration
GO_0047496Biological processvesicle transport along microtubule
GO_0007166Biological processcell surface receptor signaling pathway
GO_0045630Biological processpositive regulation of T-helper 2 cell differentiation
GO_0016324Cellular componentapical plasma membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0070160Cellular componenttight junction
GO_0031982Cellular componentvesicle
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005815Cellular componentmicrotubule organizing center
GO_0043203Cellular componentaxon hillock
GO_0070062Cellular componentextracellular exosome
GO_0005635Cellular componentnuclear envelope
GO_0031252Cellular componentcell leading edge
GO_0045179Cellular componentapical cortex
GO_0005911Cellular componentcell-cell junction
GO_0016363Cellular componentnuclear matrix
GO_0001725Cellular componentstress fiber
GO_0005829Cellular componentcytosol
GO_0120157Cellular componentPAR polarity complex
GO_0035748Cellular componentmyelin sheath abaxonal region
GO_0014069Cellular componentpostsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0030054Cellular componentcell junction
GO_0005768Cellular componentendosome
GO_0106310Molecular functionprotein serine kinase activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0071889Molecular function14-3-3 protein binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0043560Molecular functioninsulin receptor substrate binding
GO_0004672Molecular functionprotein kinase activity
GO_0043274Molecular functionphospholipase binding
GO_0015459Molecular functionpotassium channel regulator activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKCZ
Protein nameProtein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Protein kinase C zeta
SynonymsPKC2
DescriptionFUNCTION: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro . .; FUNCTION: [Isoform 2]: Involved in late synaptic long term potention phase in CA1 hippocampal cells and long term memory maintenance. .

AccessionsENST00000468310.5
ENST00000470596.5
ENST00000496325.5
ENST00000497183.5
ENST00000471018.6
ENST00000378567.8 [Q05513-1]
D6RAN5
D6RC84
ENST00000470511.5
F2Z3C5
ENST00000466352.5
D6RBD4
E9PBE1
D6RCN4
ENST00000461465.5
D6RD31
ENST00000470986.5
ENST00000486681.5
D6RDM0
ENST00000478770.6
F2Z2H9
J3KRP7
ENST00000503297.1
ENST00000482686.5
D6RAU1
D6REZ8
D6RJG4
ENST00000495347.5
ENST00000461106.6 [Q05513-3]
ENST00000400921.6 [Q05513-2]
Q05513
D6RGG1
D6RG01
ENST00000481140.5