PRDX5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	37 studies	44% ± 13%	Explore
fibroblast	35 studies	51% ± 17%	Explore
B cell	32 studies	36% ± 12%	Explore
endothelial cell	32 studies	44% ± 17%	Explore
macrophage	31 studies	40% ± 15%	Explore
CD8-positive, alpha-beta T cell	30 studies	37% ± 16%	Explore
pericyte	29 studies	41% ± 17%	Explore
conventional dendritic cell	27 studies	42% ± 13%	Explore
T cell	26 studies	35% ± 11%	Explore
CD4-positive, alpha-beta T cell	26 studies	35% ± 14%	Explore
classical monocyte	25 studies	45% ± 15%	Explore
smooth muscle cell	24 studies	38% ± 14%	Explore
epithelial cell	24 studies	67% ± 21%	Explore
non-classical monocyte	23 studies	46% ± 15%	Explore
plasma cell	22 studies	51% ± 20%	Explore
basal cell	21 studies	69% ± 20%	Explore
regulatory T cell	21 studies	37% ± 13%	Explore
plasmacytoid dendritic cell	20 studies	43% ± 14%	Explore
monocyte	19 studies	42% ± 14%	Explore
ciliated cell	19 studies	87% ± 16%	Explore
memory B cell	19 studies	32% ± 9%	Explore
connective tissue cell	19 studies	51% ± 21%	Explore
endothelial cell of lymphatic vessel	18 studies	56% ± 15%	Explore
dendritic cell	16 studies	45% ± 22%	Explore
mature NK T cell	16 studies	40% ± 12%	Explore
naive B cell	16 studies	32% ± 7%	Explore
gamma-delta T cell	16 studies	41% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	40% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	47% ± 12%	Explore
mast cell	14 studies	34% ± 15%	Explore
myeloid cell	14 studies	43% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	27% ± 6%	Explore
myofibroblast cell	13 studies	49% ± 17%	Explore
plasmablast	12 studies	59% ± 19%	Explore
secretory cell	12 studies	71% ± 20%	Explore
capillary endothelial cell	12 studies	34% ± 14%	Explore
goblet cell	12 studies	53% ± 24%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	37% ± 12%	Explore
endothelial cell of artery	11 studies	40% ± 17%	Explore
vein endothelial cell	11 studies	39% ± 18%	Explore
endothelial cell of vascular tree	11 studies	34% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	39% ± 17%	Explore
progenitor cell	10 studies	61% ± 22%	Explore
abnormal cell	10 studies	59% ± 20%	Explore
mesothelial cell	10 studies	69% ± 20%	Explore
mucosal invariant T cell	10 studies	30% ± 5%	Explore
type I pneumocyte	9 studies	66% ± 20%	Explore
type II pneumocyte	9 studies	74% ± 25%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	39% ± 17%	Explore
platelet	9 studies	31% ± 9%	Explore
innate lymphoid cell	8 studies	35% ± 8%	Explore
club cell	8 studies	74% ± 22%	Explore
neutrophil	8 studies	32% ± 9%	Explore
leukocyte	8 studies	38% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	34% ± 11%	Explore
neuron	8 studies	50% ± 29%	Explore
T follicular helper cell	8 studies	32% ± 8%	Explore
ionocyte	7 studies	77% ± 12%	Explore
epithelial cell of proximal tubule	7 studies	62% ± 20%	Explore
enterocyte	7 studies	55% ± 19%	Explore
IgG plasma cell	7 studies	34% ± 15%	Explore
hematopoietic precursor cell	6 studies	47% ± 24%	Explore
respiratory goblet cell	6 studies	68% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	48% ± 16%	Explore
kidney loop of Henle epithelial cell	6 studies	71% ± 18%	Explore
renal alpha-intercalated cell	6 studies	84% ± 7%	Explore
enteroendocrine cell	6 studies	68% ± 24%	Explore
intestinal crypt stem cell	6 studies	66% ± 28%	Explore
IgA plasma cell	6 studies	36% ± 15%	Explore
transit amplifying cell	6 studies	62% ± 31%	Explore
retinal ganglion cell	6 studies	71% ± 32%	Explore
astrocyte	6 studies	42% ± 20%	Explore
hematopoietic stem cell	6 studies	40% ± 16%	Explore
alveolar macrophage	5 studies	42% ± 9%	Explore
exhausted T cell	5 studies	50% ± 11%	Explore
mononuclear phagocyte	5 studies	47% ± 20%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	78% ± 3%	Explore
erythroblast	5 studies	38% ± 23%	Explore
microglial cell	5 studies	31% ± 15%	Explore
retinal cone cell	5 studies	56% ± 26%	Explore
retinal rod cell	5 studies	42% ± 16%	Explore
granulocyte	5 studies	31% ± 13%	Explore
deuterosomal cell	4 studies	53% ± 12%	Explore
duct epithelial cell	4 studies	79% ± 6%	Explore
squamous epithelial cell	4 studies	59% ± 20%	Explore
pancreatic A cell	4 studies	80% ± 14%	Explore
type B pancreatic cell	4 studies	77% ± 14%	Explore
glutamatergic neuron	4 studies	29% ± 9%	Explore
glomerular endothelial cell	4 studies	36% ± 13%	Explore
OFF-bipolar cell	4 studies	55% ± 31%	Explore
ON-bipolar cell	4 studies	55% ± 31%	Explore
megakaryocyte	4 studies	41% ± 16%	Explore
precursor B cell	4 studies	40% ± 10%	Explore
erythrocyte	4 studies	45% ± 22%	Explore
immature B cell	4 studies	49% ± 14%	Explore
amacrine cell	4 studies	65% ± 13%	Explore
retina horizontal cell	4 studies	50% ± 22%	Explore
adventitial cell	4 studies	47% ± 8%	Explore
mucus secreting cell	4 studies	55% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	57% ± 15%	Explore
intermediate monocyte	4 studies	55% ± 17%	Explore
CD4-positive helper T cell	4 studies	22% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	51% ± 9%	Explore
GABAergic neuron	4 studies	20% ± 3%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	47% ± 19%	Explore
group 3 innate lymphoid cell	4 studies	52% ± 11%	Explore
T-helper 17 cell	4 studies	43% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	32% ± 6%	Explore
precursor cell	3 studies	70% ± 10%	Explore
pancreatic D cell	3 studies	79% ± 14%	Explore
kidney connecting tubule epithelial cell	3 studies	78% ± 13%	Explore
podocyte	3 studies	61% ± 12%	Explore
neural crest cell	3 studies	46% ± 7%	Explore
retinal bipolar neuron	3 studies	60% ± 24%	Explore
GABAergic amacrine cell	3 studies	45% ± 16%	Explore
renal principal cell	3 studies	76% ± 8%	Explore
extravillous trophoblast	3 studies	96% ± 2%	Explore
placental villous trophoblast	3 studies	90% ± 11%	Explore
common myeloid progenitor	3 studies	46% ± 24%	Explore
lymphocyte	3 studies	56% ± 10%	Explore
pro-B cell	3 studies	35% ± 4%	Explore
brush cell	3 studies	49% ± 25%	Explore
neuroendocrine cell	3 studies	75% ± 21%	Explore
retinal pigment epithelial cell	3 studies	53% ± 28%	Explore
serous secreting cell	3 studies	60% ± 3%	Explore
intraepithelial lymphocyte	3 studies	53% ± 5%	Explore
Mueller cell	3 studies	49% ± 12%	Explore
rod bipolar cell	3 studies	52% ± 22%	Explore
oligodendrocyte	3 studies	25% ± 5%	Explore
germinal center B cell	3 studies	46% ± 2%	Explore
myoepithelial cell	3 studies	68% ± 13%	Explore
inflammatory macrophage	3 studies	28% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	35% ± 9%	Explore
IgM plasma cell	3 studies	45% ± 12%	Explore
acinar cell	3 studies	42% ± 17%	Explore
pancreatic ductal cell	3 studies	77% ± 6%	Explore
oligodendrocyte precursor cell	3 studies	44% ± 11%	Explore
granulocyte monocyte progenitor cell	3 studies	55% ± 28%	Explore
glial cell	3 studies	49% ± 23%	Explore
hepatocyte	3 studies	62% ± 26%	Explore
keratinocyte	3 studies	50% ± 9%	Explore
T-helper 1 cell	3 studies	49% ± 22%	Explore
double negative thymocyte	3 studies	51% ± 20%	Explore
progenitor cell of mammary luminal epithelium	3 studies	53% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	52% ± 21%	Explore
peripheral blood	18 studies	37% ± 12%	Explore
intestine	14 studies	44% ± 22%	Explore
kidney	9 studies	49% ± 15%	Explore
eye	8 studies	45% ± 17%	Explore
brain	7 studies	29% ± 6%	Explore
lymph node	6 studies	42% ± 18%	Explore
placenta	5 studies	55% ± 34%	Explore
bone marrow	5 studies	30% ± 15%	Explore
uterus	5 studies	59% ± 18%	Explore
liver	5 studies	38% ± 22%	Explore
pancreas	4 studies	71% ± 16%	Explore
prostate	4 studies	48% ± 19%	Explore
breast	4 studies	45% ± 5%	Explore
ovary	3 studies	35% ± 7%	Explore
adrenal gland	3 studies	39% ± 5%	Explore
esophagus	3 studies	61% ± 28%	Explore
skin	3 studies	35% ± 10%	Explore
thymus	3 studies	58% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	13742.82	258 / 258	100%	1204.56	230 / 230
ovary	100%	8112.85	180 / 180	100%	814.95	430 / 430
thymus	100%	13566.04	653 / 653	100%	1713.06	605 / 605
brain	100%	10526.38	2640 / 2642	100%	852.75	705 / 705
skin	100%	6345.54	1806 / 1809	100%	716.41	472 / 472
uterus	100%	5907.22	170 / 170	100%	1102.47	457 / 459
kidney	100%	11551.27	89 / 89	99%	892.98	896 / 901
liver	100%	5229.00	225 / 226	100%	725.67	405 / 406
prostate	100%	6107.48	245 / 245	99%	703.33	498 / 502
pancreas	100%	4244.34	327 / 328	99%	887.26	177 / 178
bladder	100%	6312.90	21 / 21	98%	1181.08	495 / 504
intestine	100%	7876.54	966 / 966	98%	1377.02	517 / 527
breast	100%	6245.97	459 / 459	98%	608.14	1092 / 1118
lung	100%	7946.50	576 / 578	98%	852.43	1127 / 1155
stomach	100%	8197.38	359 / 359	96%	1063.15	274 / 286
esophagus	100%	7987.75	1444 / 1445	96%	341.19	175 / 183
adipose	100%	5940.94	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	1150.03	80 / 80
lymph node	0%	0	0 / 0	100%	1013.82	29 / 29
spleen	100%	5674.87	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	951.77	45 / 45
ureter	0%	0	0 / 0	100%	910.83	1 / 1
muscle	100%	6760.05	801 / 803	0%	0	0 / 0
peripheral blood	99%	7644.87	922 / 929	0%	0	0 / 0
blood vessel	98%	3781.72	1314 / 1335	0%	0	0 / 0
heart	98%	9845.02	846 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0045454	Biological process	cell redox homeostasis
GO_0034614	Biological process	cellular response to reactive oxygen species
GO_0006954	Biological process	inflammatory response
GO_0098869	Biological process	cellular oxidant detoxification
GO_0042744	Biological process	hydrogen peroxide catabolic process
GO_0016480	Biological process	negative regulation of transcription by RNA polymerase III
GO_0034599	Biological process	cellular response to oxidative stress
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0006979	Biological process	response to oxidative stress
GO_0005615	Cellular component	extracellular space
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0070062	Cellular component	extracellular exosome
GO_0005777	Cellular component	peroxisome
GO_0005829	Cellular component	cytosol
GO_0005782	Cellular component	peroxisomal matrix
GO_0005759	Cellular component	mitochondrial matrix
GO_0005737	Cellular component	cytoplasm
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0005634	Cellular component	nucleus
GO_0004601	Molecular function	peroxidase activity
GO_0043027	Molecular function	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO_0008379	Molecular function	thioredoxin peroxidase activity
GO_0001016	Molecular function	RNA polymerase III transcription regulatory region sequence-specific DNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PRDX5
Protein name	Peroxiredoxin-5, mitochondrial (EC 1.11.1.24) (Alu corepressor 1) (Antioxidant enzyme B166) (AOEB166) (Liver tissue 2D-page spot 71B) (PLP) (Peroxiredoxin V) (Prx-V) (Peroxisomal antioxidant enzyme) (TPx type VI) (Thioredoxin peroxidase PMP20) (Thioredoxin-dependent peroxiredoxin 5)
Synonyms	SBBI10 ACR1
Description	FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. .
Accessions	ENST00000347941.4 [P30044-4] P30044 ENST00000352435.8 [P30044-3] ENST00000265462.9 [P30044-1]

PRDX5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review