Insufficient scRNA-seq data for expression of NLRC4 at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 95% | 113.22 | 435 / 459 | 93% | 2.59 | 1037 / 1118 |
| lung | 100% | 533.21 | 577 / 578 | 86% | 2.88 | 999 / 1155 |
| brain | 92% | 93.48 | 2425 / 2642 | 89% | 2.72 | 628 / 705 |
| pancreas | 85% | 62.96 | 280 / 328 | 85% | 2.59 | 151 / 178 |
| thymus | 87% | 68.50 | 566 / 653 | 80% | 1.61 | 481 / 605 |
| adrenal gland | 100% | 209.41 | 258 / 258 | 62% | 1.04 | 142 / 230 |
| uterus | 93% | 70.06 | 158 / 170 | 68% | 1.35 | 313 / 459 |
| kidney | 81% | 70.56 | 72 / 89 | 78% | 3.00 | 706 / 901 |
| bladder | 100% | 97.43 | 21 / 21 | 55% | 1.33 | 277 / 504 |
| ovary | 87% | 58.53 | 156 / 180 | 64% | 1.20 | 274 / 430 |
| intestine | 97% | 107.97 | 940 / 966 | 50% | 1.07 | 265 / 527 |
| stomach | 75% | 69.73 | 271 / 359 | 63% | 1.34 | 180 / 286 |
| liver | 98% | 97.21 | 221 / 226 | 39% | 0.71 | 157 / 406 |
| esophagus | 76% | 60.29 | 1097 / 1445 | 51% | 0.94 | 94 / 183 |
| skin | 54% | 33.29 | 971 / 1809 | 72% | 2.03 | 340 / 472 |
| prostate | 91% | 77.80 | 224 / 245 | 31% | 0.44 | 157 / 502 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 4.51 | 29 / 29 |
| spleen | 100% | 1407.97 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 100% | 4530.97 | 925 / 929 | 0% | 0 | 0 / 0 |
| adipose | 99% | 221.66 | 1189 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 97% | 98.08 | 779 / 803 | 0% | 0 | 0 / 0 |
| heart | 94% | 123.77 | 808 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 83% | 99.47 | 1112 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 76% | 1.54 | 34 / 45 |
| eye | 0% | 0 | 0 / 0 | 20% | 0.35 | 16 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0051260 | Biological process | protein homooligomerization |
| GO_0002221 | Biological process | pattern recognition receptor signaling pathway |
| GO_0006954 | Biological process | inflammatory response |
| GO_0016045 | Biological process | detection of bacterium |
| GO_0046456 | Biological process | icosanoid biosynthetic process |
| GO_0045087 | Biological process | innate immune response |
| GO_0070269 | Biological process | pyroptotic inflammatory response |
| GO_0097202 | Biological process | activation of cysteine-type endopeptidase activity |
| GO_0032731 | Biological process | positive regulation of interleukin-1 beta production |
| GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
| GO_0010954 | Biological process | positive regulation of protein processing |
| GO_0042742 | Biological process | defense response to bacterium |
| GO_0002218 | Biological process | activation of innate immune response |
| GO_0006915 | Biological process | apoptotic process |
| GO_0050729 | Biological process | positive regulation of inflammatory response |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0072557 | Cellular component | IPAF inflammasome complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0061702 | Cellular component | canonical inflammasome complex |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0061133 | Molecular function | endopeptidase activator activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0000287 | Molecular function | magnesium ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0089720 | Molecular function | caspase binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | NLRC4 |
| Protein name | NLR family CARD domain-containing protein 4 (CARD, LRR, and NACHT-containing protein) (CED-4-like protein Clan) (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf) NLR family CARD domain-containing protein 4 (Ice protease-activating factor) NLR family CARD domain containing 4 |
| Synonyms | CLAN UNQ6189/PRO20215 IPAF CLAN1 CARD12 |
| Description | FUNCTION: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis . The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity). . |
| Accessions | A0A494BZZ1 Q9NPP4 ENST00000404025.3 ENST00000652197.2 ENST00000402280.6 [Q9NPP4-1] A0A499FIV7 ENST00000360906.9 [Q9NPP4-1] ENST00000342905.10 [Q9NPP4-2] |
