CCL20 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_0019722Biological processcalcium-mediated signaling
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007165Biological processsignal transduction
GO_0006935Biological processchemotaxis
GO_0007267Biological processcell-cell signaling
GO_0006955Biological processimmune response
GO_0072679Biological processthymocyte migration
GO_0070098Biological processchemokine-mediated signaling pathway
GO_0030335Biological processpositive regulation of cell migration
GO_0042742Biological processdefense response to bacterium
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_2000406Biological processpositive regulation of T cell migration
GO_0072678Biological processT cell migration
GO_0060326Biological processcell chemotaxis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0008009Molecular functionchemokine activity
GO_0048020Molecular functionCCR chemokine receptor binding
GO_0005515Molecular functionprotein binding
GO_0031731Molecular functionCCR6 chemokine receptor binding

IV. Literature review

[source]
Gene nameCCL20
Protein nameC-C motif chemokine ligand 20
C-C motif chemokine 20 (Beta-chemokine exodus-1) (CC chemokine LARC) (Liver and activation-regulated chemokine) (Macrophage inflammatory protein 3 alpha) (MIP-3-alpha) (Small-inducible cytokine A20) [Cleaved into: CCL20(1-67); CCL20(1-64); CCL20(2-70)]
SynonymsSCYA20
MIP3A
LARC
DescriptionFUNCTION: Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions . The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases . CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes . Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes . Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility . Inhibits proliferation of myeloid progenitors in colony formation assays . May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 . .

AccessionsENST00000409189.7 [P78556-2]
ENST00000646475.1
A0A2R8Y806
ENST00000358813.5 [P78556-1]
P78556