RARRES2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061760Biological processantifungal innate immune response
GO_0006954Biological processinflammatory response
GO_0050921Biological processpositive regulation of chemotaxis
GO_0045087Biological processinnate immune response
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_0048566Biological processembryonic digestive tract development
GO_0006935Biological processchemotaxis
GO_0001934Biological processpositive regulation of protein phosphorylation
GO_0010759Biological processpositive regulation of macrophage chemotaxis
GO_0001523Biological processretinoid metabolic process
GO_0008286Biological processinsulin receptor signaling pathway
GO_0050830Biological processdefense response to Gram-positive bacterium
GO_0050994Biological processregulation of lipid catabolic process
GO_0030154Biological processcell differentiation
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0019732Biological processantifungal humoral response
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0031012Cellular componentextracellular matrix
GO_0031089Cellular componentplatelet dense granule lumen
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRARRES2
Protein nameRetinoic acid receptor responder protein 2 (Chemerin)
Retinoic acid receptor responder protein 2 (Chemerin) (RAR-responsive protein TIG2) (Tazarotene-induced gene 2 protein)
SynonymsTIG2
tcag7.770
DescriptionFUNCTION: Adipocyte-secreted protein (adipokine) that regulates adipogenesis, metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Acts also as a ligand for CMKLR2. Can also bind to C-C chemokine receptor-like 2 (CCRL2), but with a lower affinity than it does to CMKLR1 or CMKLR2 . Positively regulates adipocyte differentiation, modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis, a process essential for the expansion of white adipose tissue. Also acts as a pro-inflammatory adipokine, causing an increase in secretion of pro-inflammatory and prodiabetic adipokines, which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity, altered glucose and lipid metabolism, and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1, particularly immature plasmacytoid dendritic cells, but also immature myeloid DCs, macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity, as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin. .

AccessionsA0A090N7U9
Q99969
ENST00000482669.1
ENST00000223271.8
ENST00000467793.5
C9J8S2
ENST00000466675.5