Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| dendritic cell | 14 studies | 36% ± 15% | |
| glutamatergic neuron | 13 studies | 65% ± 21% | |
| oligodendrocyte precursor cell | 13 studies | 38% ± 15% | |
| astrocyte | 13 studies | 35% ± 13% | |
| macrophage | 13 studies | 36% ± 17% | |
| microglial cell | 12 studies | 33% ± 16% | |
| GABAergic neuron | 11 studies | 61% ± 23% | |
| ciliated cell | 10 studies | 30% ± 12% | |
| pericyte | 10 studies | 38% ± 15% | |
| endothelial cell | 10 studies | 38% ± 17% | |
| epithelial cell | 9 studies | 38% ± 13% | |
| plasmacytoid dendritic cell | 9 studies | 31% ± 11% | |
| myeloid cell | 8 studies | 32% ± 11% | |
| basal cell | 8 studies | 32% ± 20% | |
| adipocyte | 8 studies | 27% ± 6% | |
| fibroblast | 8 studies | 29% ± 11% | |
| endothelial cell of lymphatic vessel | 7 studies | 34% ± 12% | |
| neuron | 7 studies | 54% ± 24% | |
| interneuron | 7 studies | 62% ± 26% | |
| cardiac muscle cell | 6 studies | 58% ± 23% | |
| smooth muscle cell | 6 studies | 25% ± 5% | |
| intestinal crypt stem cell | 5 studies | 31% ± 7% | |
| transit amplifying cell | 5 studies | 37% ± 29% | |
| retinal ganglion cell | 5 studies | 40% ± 24% | |
| club cell | 5 studies | 23% ± 8% | |
| amacrine cell | 5 studies | 34% ± 16% | |
| retina horizontal cell | 5 studies | 35% ± 18% | |
| Mueller cell | 5 studies | 37% ± 11% | |
| monocyte | 5 studies | 38% ± 10% | |
| granule cell | 4 studies | 53% ± 12% | |
| brush cell | 4 studies | 34% ± 12% | |
| goblet cell | 4 studies | 39% ± 31% | |
| classical monocyte | 3 studies | 21% ± 4% | |
| hematopoietic precursor cell | 3 studies | 27% ± 3% | |
| GABAergic interneuron | 3 studies | 70% ± 2% | |
| GABAergic amacrine cell | 3 studies | 50% ± 17% | |
| glycinergic amacrine cell | 3 studies | 42% ± 15% | |
| hepatocyte | 3 studies | 46% ± 16% | |
| neural progenitor cell | 3 studies | 30% ± 9% | |
| ependymal cell | 3 studies | 42% ± 19% | |
| granulocyte monocyte progenitor cell | 3 studies | 29% ± 9% | |
| enteroendocrine cell | 3 studies | 32% ± 2% | |
| alveolar macrophage | 3 studies | 47% ± 9% | |
| lymphocyte | 3 studies | 21% ± 2% | |
| mast cell | 3 studies | 25% ± 6% | |
| podocyte | 3 studies | 63% ± 18% | |
| mucus secreting cell | 3 studies | 27% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1293.99 | 1443 / 1445 | 99% | 32.88 | 182 / 183 |
| stomach | 100% | 1787.55 | 359 / 359 | 97% | 33.07 | 277 / 286 |
| intestine | 99% | 1164.30 | 952 / 966 | 98% | 29.80 | 516 / 527 |
| breast | 100% | 1160.50 | 458 / 459 | 96% | 48.80 | 1077 / 1118 |
| lung | 99% | 1000.12 | 573 / 578 | 93% | 20.41 | 1072 / 1155 |
| ovary | 100% | 1495.16 | 180 / 180 | 83% | 10.27 | 355 / 430 |
| thymus | 100% | 957.53 | 651 / 653 | 80% | 13.93 | 487 / 605 |
| bladder | 100% | 998.57 | 21 / 21 | 80% | 16.26 | 404 / 504 |
| uterus | 100% | 1554.31 | 170 / 170 | 79% | 11.09 | 362 / 459 |
| prostate | 100% | 980.73 | 244 / 245 | 78% | 11.90 | 393 / 502 |
| brain | 90% | 924.45 | 2383 / 2642 | 84% | 10.83 | 593 / 705 |
| pancreas | 82% | 405.02 | 269 / 328 | 86% | 15.24 | 153 / 178 |
| skin | 100% | 2139.30 | 1809 / 1809 | 64% | 9.10 | 304 / 472 |
| kidney | 98% | 641.01 | 87 / 89 | 64% | 8.13 | 581 / 901 |
| adrenal gland | 100% | 1029.30 | 258 / 258 | 62% | 9.50 | 142 / 230 |
| liver | 82% | 439.35 | 186 / 226 | 32% | 3.25 | 130 / 406 |
| adipose | 100% | 1409.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1060.28 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| heart | 94% | 1902.41 | 813 / 861 | 0% | 0 | 0 / 0 |
| muscle | 93% | 616.63 | 746 / 803 | 0% | 0 | 0 / 0 |
| spleen | 85% | 373.53 | 204 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 16.94 | 37 / 45 |
| peripheral blood | 56% | 820.12 | 522 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 33% | 2.82 | 26 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 2.48 | 8 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1900143 | Biological process | positive regulation of oligodendrocyte apoptotic process |
| GO_0030148 | Biological process | sphingolipid biosynthetic process |
| GO_0014003 | Biological process | oligodendrocyte development |
| GO_0006954 | Biological process | inflammatory response |
| GO_0046513 | Biological process | ceramide biosynthetic process |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0003677 | Molecular function | DNA binding |
| GO_0050291 | Molecular function | sphingosine N-acyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | CERS6 |
| Protein name | Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291) |
| Synonyms | LASS6 |
| Description | FUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) . Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively . Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). . |
| Accessions | ENST00000305747.11 [Q6ZMG9-1] ENST00000392687.4 [Q6ZMG9-2] Q6ZMG9 |