Name | Number of supported studies | Average coverage | |
---|---|---|---|
dendritic cell | 14 studies | 36% ± 15% | |
glutamatergic neuron | 13 studies | 65% ± 21% | |
oligodendrocyte precursor cell | 13 studies | 38% ± 15% | |
astrocyte | 13 studies | 35% ± 13% | |
macrophage | 13 studies | 36% ± 17% | |
microglial cell | 12 studies | 33% ± 16% | |
GABAergic neuron | 11 studies | 61% ± 23% | |
ciliated cell | 10 studies | 30% ± 12% | |
pericyte | 10 studies | 38% ± 15% | |
endothelial cell | 10 studies | 38% ± 17% | |
epithelial cell | 9 studies | 38% ± 13% | |
plasmacytoid dendritic cell | 9 studies | 31% ± 11% | |
myeloid cell | 8 studies | 32% ± 11% | |
basal cell | 8 studies | 32% ± 20% | |
adipocyte | 8 studies | 27% ± 6% | |
fibroblast | 8 studies | 29% ± 11% | |
endothelial cell of lymphatic vessel | 7 studies | 34% ± 12% | |
neuron | 7 studies | 54% ± 24% | |
interneuron | 7 studies | 62% ± 26% | |
cardiac muscle cell | 6 studies | 58% ± 23% | |
smooth muscle cell | 6 studies | 25% ± 5% | |
intestinal crypt stem cell | 5 studies | 31% ± 7% | |
transit amplifying cell | 5 studies | 37% ± 29% | |
retinal ganglion cell | 5 studies | 40% ± 24% | |
club cell | 5 studies | 23% ± 8% | |
amacrine cell | 5 studies | 34% ± 16% | |
retina horizontal cell | 5 studies | 35% ± 18% | |
Mueller cell | 5 studies | 37% ± 11% | |
monocyte | 5 studies | 38% ± 10% | |
granule cell | 4 studies | 53% ± 12% | |
brush cell | 4 studies | 34% ± 12% | |
goblet cell | 4 studies | 39% ± 31% | |
classical monocyte | 3 studies | 21% ± 4% | |
hematopoietic precursor cell | 3 studies | 27% ± 3% | |
GABAergic interneuron | 3 studies | 70% ± 2% | |
GABAergic amacrine cell | 3 studies | 50% ± 17% | |
glycinergic amacrine cell | 3 studies | 42% ± 15% | |
hepatocyte | 3 studies | 46% ± 16% | |
neural progenitor cell | 3 studies | 30% ± 9% | |
ependymal cell | 3 studies | 42% ± 19% | |
granulocyte monocyte progenitor cell | 3 studies | 29% ± 9% | |
enteroendocrine cell | 3 studies | 32% ± 2% | |
alveolar macrophage | 3 studies | 47% ± 9% | |
lymphocyte | 3 studies | 21% ± 2% | |
mast cell | 3 studies | 25% ± 6% | |
podocyte | 3 studies | 63% ± 18% | |
mucus secreting cell | 3 studies | 27% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1293.99 | 1443 / 1445 | 99% | 32.88 | 182 / 183 |
stomach | 100% | 1787.55 | 359 / 359 | 97% | 33.07 | 277 / 286 |
intestine | 99% | 1164.30 | 952 / 966 | 98% | 29.80 | 516 / 527 |
breast | 100% | 1160.50 | 458 / 459 | 96% | 48.80 | 1077 / 1118 |
lung | 99% | 1000.12 | 573 / 578 | 93% | 20.41 | 1072 / 1155 |
ovary | 100% | 1495.16 | 180 / 180 | 83% | 10.27 | 355 / 430 |
thymus | 100% | 957.53 | 651 / 653 | 80% | 13.93 | 487 / 605 |
bladder | 100% | 998.57 | 21 / 21 | 80% | 16.26 | 404 / 504 |
uterus | 100% | 1554.31 | 170 / 170 | 79% | 11.09 | 362 / 459 |
prostate | 100% | 980.73 | 244 / 245 | 78% | 11.90 | 393 / 502 |
brain | 90% | 924.45 | 2383 / 2642 | 84% | 10.83 | 593 / 705 |
pancreas | 82% | 405.02 | 269 / 328 | 86% | 15.24 | 153 / 178 |
skin | 100% | 2139.30 | 1809 / 1809 | 64% | 9.10 | 304 / 472 |
kidney | 98% | 641.01 | 87 / 89 | 64% | 8.13 | 581 / 901 |
adrenal gland | 100% | 1029.30 | 258 / 258 | 62% | 9.50 | 142 / 230 |
liver | 82% | 439.35 | 186 / 226 | 32% | 3.25 | 130 / 406 |
adipose | 100% | 1409.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1060.28 | 1331 / 1335 | 0% | 0 | 0 / 0 |
heart | 94% | 1902.41 | 813 / 861 | 0% | 0 | 0 / 0 |
muscle | 93% | 616.63 | 746 / 803 | 0% | 0 | 0 / 0 |
spleen | 85% | 373.53 | 204 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 82% | 16.94 | 37 / 45 |
peripheral blood | 56% | 820.12 | 522 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 33% | 2.82 | 26 / 80 |
lymph node | 0% | 0 | 0 / 0 | 28% | 2.48 | 8 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_1900143 | Biological process | positive regulation of oligodendrocyte apoptotic process |
GO_0030148 | Biological process | sphingolipid biosynthetic process |
GO_0014003 | Biological process | oligodendrocyte development |
GO_0006954 | Biological process | inflammatory response |
GO_0046513 | Biological process | ceramide biosynthetic process |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0003677 | Molecular function | DNA binding |
GO_0050291 | Molecular function | sphingosine N-acyltransferase activity |
GO_0005515 | Molecular function | protein binding |
Gene name | CERS6 |
Protein name | Ceramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291) |
Synonyms | LASS6 |
Description | FUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) . Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively . Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). . |
Accessions | ENST00000305747.11 [Q6ZMG9-1] ENST00000392687.4 [Q6ZMG9-2] Q6ZMG9 |