CERS6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1900143Biological processpositive regulation of oligodendrocyte apoptotic process
GO_0030148Biological processsphingolipid biosynthetic process
GO_0014003Biological processoligodendrocyte development
GO_0006954Biological processinflammatory response
GO_0046513Biological processceramide biosynthetic process
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0003677Molecular functionDNA binding
GO_0050291Molecular functionsphingosine N-acyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCERS6
Protein nameCeramide synthase 6 (CerS6) (LAG1 longevity assurance homolog 6) (Sphingoid base N-palmitoyltransferase CERS6) (EC 2.3.1.291)
SynonymsLASS6
DescriptionFUNCTION: Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) . Can use other acyl donors, but with less efficiency (By similarity). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively . Ceramides generated by CERS6 play a role in inflammatory response (By similarity). Acts as a regulator of metabolism and hepatic lipid accumulation (By similarity). Under high fat diet, palmitoyl- (C16:0-) ceramides generated by CERS6 specifically bind the mitochondrial fission factor MFF, thereby promoting mitochondrial fragmentation and contributing to the development of obesity (By similarity). .

AccessionsENST00000305747.11 [Q6ZMG9-1]
ENST00000392687.4 [Q6ZMG9-2]
Q6ZMG9