Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| dendritic cell | 12 studies | 41% ± 22% | |
| conventional dendritic cell | 10 studies | 26% ± 8% | |
| endothelial cell of artery | 4 studies | 31% ± 11% | |
| monocyte | 3 studies | 20% ± 4% | |
| endothelial cell | 3 studies | 18% ± 1% | |
| epithelial cell | 3 studies | 26% ± 5% |
Insufficient scRNA-seq data for expression of IDO1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 1569.83 | 576 / 578 | 76% | 37.49 | 874 / 1155 |
| thymus | 96% | 331.44 | 630 / 653 | 31% | 5.59 | 189 / 605 |
| uterus | 50% | 79.28 | 85 / 170 | 77% | 80.12 | 354 / 459 |
| intestine | 72% | 238.99 | 691 / 966 | 46% | 20.67 | 244 / 527 |
| kidney | 52% | 59.21 | 46 / 89 | 56% | 19.41 | 508 / 901 |
| stomach | 49% | 133.29 | 175 / 359 | 51% | 38.93 | 146 / 286 |
| spleen | 95% | 373.69 | 230 / 241 | 0% | 0 | 0 / 0 |
| bladder | 43% | 34.48 | 9 / 21 | 47% | 34.36 | 237 / 504 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 73.04 | 26 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 100.59 | 40 / 45 |
| breast | 49% | 133.04 | 227 / 459 | 38% | 15.98 | 425 / 1118 |
| esophagus | 37% | 65.53 | 541 / 1445 | 50% | 24.99 | 91 / 183 |
| prostate | 63% | 151.24 | 155 / 245 | 23% | 3.17 | 116 / 502 |
| ovary | 20% | 18.47 | 36 / 180 | 62% | 19.70 | 268 / 430 |
| muscle | 70% | 132.11 | 566 / 803 | 0% | 0 | 0 / 0 |
| skin | 23% | 17.88 | 424 / 1809 | 45% | 19.72 | 213 / 472 |
| adipose | 63% | 398.89 | 758 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 21% | 22.57 | 54 / 258 | 28% | 4.39 | 64 / 230 |
| pancreas | 9% | 6.11 | 30 / 328 | 39% | 11.32 | 69 / 178 |
| peripheral blood | 40% | 76.23 | 367 / 929 | 0% | 0 | 0 / 0 |
| heart | 30% | 46.41 | 259 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 22% | 25.26 | 300 / 1335 | 0% | 0 | 0 / 0 |
| liver | 8% | 4.49 | 17 / 226 | 12% | 2.06 | 50 / 406 |
| eye | 0% | 0 | 0 / 0 | 10% | 1.89 | 8 / 80 |
| brain | 1% | 15.97 | 25 / 2642 | 3% | 0.74 | 22 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0002678 | Biological process | positive regulation of chronic inflammatory response |
| GO_0070233 | Biological process | negative regulation of T cell apoptotic process |
| GO_0002666 | Biological process | positive regulation of T cell tolerance induction |
| GO_0006954 | Biological process | inflammatory response |
| GO_0042098 | Biological process | T cell proliferation |
| GO_0019441 | Biological process | tryptophan catabolic process to kynurenine |
| GO_0032735 | Biological process | positive regulation of interleukin-12 production |
| GO_0007565 | Biological process | female pregnancy |
| GO_0032693 | Biological process | negative regulation of interleukin-10 production |
| GO_0006569 | Biological process | tryptophan catabolic process |
| GO_0034354 | Biological process | 'de novo' NAD biosynthetic process from tryptophan |
| GO_0036269 | Biological process | swimming behavior |
| GO_0070234 | Biological process | positive regulation of T cell apoptotic process |
| GO_0033555 | Biological process | multicellular organismal response to stress |
| GO_0042130 | Biological process | negative regulation of T cell proliferation |
| GO_0046006 | Biological process | regulation of activated T cell proliferation |
| GO_0032496 | Biological process | response to lipopolysaccharide |
| GO_0034276 | Biological process | kynurenic acid biosynthetic process |
| GO_0002830 | Biological process | positive regulation of type 2 immune response |
| GO_0030485 | Cellular component | smooth muscle contractile fiber |
| GO_0032421 | Cellular component | stereocilium bundle |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0009055 | Molecular function | electron transfer activity |
| GO_0004833 | Molecular function | tryptophan 2,3-dioxygenase activity |
| GO_0020037 | Molecular function | heme binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0033754 | Molecular function | indoleamine 2,3-dioxygenase activity |
| Gene name | IDO1 |
| Protein name | Indoleamine 2,3-dioxygenase 1 Indoleamine 2,3-dioxygenase 1 (IDO-1) (EC 1.13.11.52) (Indoleamine-pyrrole 2,3-dioxygenase) |
| Synonyms | INDO IDO |
| Description | FUNCTION: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway . Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses . Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells . Acts as a suppressor of anti-tumor immunity . Limits the growth of intracellular pathogens by depriving tryptophan . Protects the fetus from maternal immune rejection . . |
| Accessions | P14902 A0A348GSI3 ENST00000518804.5 E5RH36 ENST00000518237.6 E5RIX2 J3KN03 ENST00000519154.5 A0A140T9Z2 ENST00000253513.11 ENST00000522495.5 ENST00000522840.1 |
