SCN9A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0048266Biological processbehavioral response to pain
GO_0009636Biological processresponse to toxic substance
GO_0050974Biological processdetection of mechanical stimulus involved in sensory perception
GO_0006954Biological processinflammatory response
GO_0050965Biological processdetection of temperature stimulus involved in sensory perception of pain
GO_0086002Biological processcardiac muscle cell action potential involved in contraction
GO_0009791Biological processpost-embryonic development
GO_0006814Biological processsodium ion transport
GO_0035725Biological processsodium ion transmembrane transport
GO_0007623Biological processcircadian rhythm
GO_0001518Cellular componentvoltage-gated sodium channel complex
GO_0030424Cellular componentaxon
GO_0005886Cellular componentplasma membrane
GO_0005248Molecular functionvoltage-gated sodium channel activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSCN9A
Protein nameSodium voltage-gated channel alpha subunit 9
Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)
Uncharacterized protein SCN9A
Voltage-gated sodium channel subunit alpha NaV1.7
SynonymsNENA
DescriptionFUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient . It is a tetrodotoxin-sensitive Na(+) channel isoform . Plays a role in pain mechanisms, especially in the development of inflammatory pain . .

AccessionsA0A0C4DG82
ENST00000667201.2
ENST00000643319.1
ENST00000645283.1
ENST00000303354.11 [Q15858-1]
A0A590UJB2
F5C0A4
H7C064
Q53QP0
ENST00000667991.1
ENST00000642356.2 [Q15858-1]
A0A2R8YCX9
ENST00000452182.2
A0A590UK23
ENST00000409672.5 [Q15858-3]
A0A2R8Y7G0
ENST00000645907.1 [Q15858-4]
ENST00000454569.6
Q15858