TRIM14 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM14 at tissue level.

III. Associated gene sets

GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0016567Biological processprotein ubiquitination
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006954Biological processinflammatory response
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0032897Biological processnegative regulation of viral transcription
GO_0045087Biological processinnate immune response
GO_0005741Cellular componentmitochondrial outer membrane
GO_0045335Cellular componentphagocytic vesicle
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0060090Molecular functionmolecular adaptor activity
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM14
Protein nameTripartite motif-containing protein 14
Tripartite motif containing 14
SynonymsKIAA0129
DescriptionFUNCTION: Plays an essential role in the innate immune defense against viruses and bacteria . Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of viral replication . Plays also a role in the inhibition of ebolavirus infection by enhancing IFN-beta and NF-kappa-B activation after binding to the viral protein NP . Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways . Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation . Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression . Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity). Inhibits also OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. Mechanistically, recruits USP14 to remove the 'Lys-63'-linked ubiquitination of KDM4D, preventing its recognition by OPTN and subsequent degradation . .

AccessionsENST00000341469.7 [Q14142-1]
Q14142
ENST00000342043.3 [Q14142-1]
F2Z2M2
ENST00000475147.1
ENST00000375098.7 [Q14142-1]