CLEC7A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0051712Biological processpositive regulation of killing of cells of another organism
GO_0050766Biological processpositive regulation of phagocytosis
GO_0009756Biological processcarbohydrate mediated signaling
GO_0061760Biological processantifungal innate immune response
GO_1903431Biological processpositive regulation of cell maturation
GO_0006954Biological processinflammatory response
GO_0050850Biological processpositive regulation of calcium-mediated signaling
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045087Biological processinnate immune response
GO_0002720Biological processpositive regulation of cytokine production involved in immune response
GO_0042832Biological processdefense response to protozoan
GO_0032747Biological processpositive regulation of interleukin-23 production
GO_2000318Biological processpositive regulation of T-helper 17 type immune response
GO_0010628Biological processpositive regulation of gene expression
GO_0032735Biological processpositive regulation of interleukin-12 production
GO_0032733Biological processpositive regulation of interleukin-10 production
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0032743Biological processpositive regulation of interleukin-2 production
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0002223Biological processstimulatory C-type lectin receptor signaling pathway
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0002732Biological processpositive regulation of dendritic cell cytokine production
GO_0051251Biological processpositive regulation of lymphocyte activation
GO_0001775Biological processcell activation
GO_0030335Biological processpositive regulation of cell migration
GO_0006910Biological processphagocytosis, recognition
GO_0016046Biological processdetection of fungus
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0008037Biological processcell recognition
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0032757Biological processpositive regulation of interleukin-8 production
GO_0071639Biological processpositive regulation of monocyte chemotactic protein-1 production
GO_0001878Biological processresponse to yeast
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0032729Biological processpositive regulation of type II interferon production
GO_0032930Biological processpositive regulation of superoxide anion generation
GO_0071226Biological processcellular response to molecule of fungal origin
GO_0043122Biological processregulation of canonical NF-kappaB signal transduction
GO_0060267Biological processpositive regulation of respiratory burst
GO_0001879Biological processdetection of yeast
GO_0042110Biological processT cell activation
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0070884Biological processregulation of calcineurin-NFAT signaling cascade
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0032491Biological processdetection of molecule of fungal origin
GO_0090303Biological processpositive regulation of wound healing
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0009986Cellular componentcell surface
GO_0005737Cellular componentcytoplasm
GO_0038187Molecular functionpattern recognition receptor activity
GO_0001872Molecular function(1->3)-beta-D-glucan binding
GO_0030246Molecular functioncarbohydrate binding
GO_0046872Molecular functionmetal ion binding
GO_0042287Molecular functionMHC protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCLEC7A
Protein nameC-type lectin domain family 7 member A isoform 1
C-type lectin domain containing 7A (C-type lectin domain family 7 member A isoform 2) (cDNA FLJ59887, moderately similar to Homo sapiens C-type lectin domain family 7, member A (CLEC7A), transcript variant 4, mRNA)
C-type lectin domain containing 7A transcript variant 8
C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)
C-type lectin domain containing 7A transcript variant 7
SynonymsCLECSF12
DKFZp686L24211
BGR
UNQ539/PRO1082
DECTIN1
DescriptionFUNCTION: Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi . Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia . Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). .

AccessionsA0A2Z5YRT6
Q9BXN2
ENST00000529761.5 [Q9BXN2-1]
A0A2Z5YRU4
ENST00000310002.4 [Q9BXN2-9]
ENST00000304084.13 [Q9BXN2-1]
ENST00000531192.5 [Q9BXN2-4]
ENST00000465100.5 [Q9BXN2-10]
ENST00000525605.1
ENST00000349926.9 [Q9BXN2-8]
Q68D78
ENST00000533022.5 [Q9BXN2-3]
ENST00000396484.6 [Q9BXN2-5]
ENST00000353231.9 [Q9BXN2-2]
A0A0S2Z5Q1
ENST00000298523.9 [Q9BXN2-7]