NLRP3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NLRP3 at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_1901224Biological processpositive regulation of non-canonical NF-kappaB signal transduction
GO_0002221Biological processpattern recognition receptor signaling pathway
GO_0006954Biological processinflammatory response
GO_0032753Biological processpositive regulation of interleukin-4 production
GO_0044546Biological processNLRP3 inflammasome complex assembly
GO_0045087Biological processinnate immune response
GO_0007165Biological processsignal transduction
GO_0070269Biological processpyroptotic inflammatory response
GO_0002674Biological processnegative regulation of acute inflammatory response
GO_0032691Biological processnegative regulation of interleukin-1 beta production
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_2000553Biological processpositive regulation of T-helper 2 cell cytokine production
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0098586Biological processcellular response to virus
GO_0050728Biological processnegative regulation of inflammatory response
GO_0051604Biological processprotein maturation
GO_0007231Biological processosmosensory signaling pathway
GO_0009595Biological processdetection of biotic stimulus
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006915Biological processapoptotic process
GO_0045630Biological processpositive regulation of T-helper 2 cell differentiation
GO_0050729Biological processpositive regulation of inflammatory response
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006952Biological processdefense response
GO_0002830Biological processpositive regulation of type 2 immune response
GO_0072559Cellular componentNLRP3 inflammasome complex
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0005815Cellular componentmicrotubule organizing center
GO_0000139Cellular componentGolgi membrane
GO_0031021Cellular componentinterphase microtubule organizing center
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043531Molecular functionADP binding
GO_0042834Molecular functionpeptidoglycan binding
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0043565Molecular functionsequence-specific DNA binding
GO_0042802Molecular functionidentical protein binding
GO_0035591Molecular functionsignaling adaptor activity
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005524Molecular functionATP binding
GO_0140608Molecular functioncysteine-type endopeptidase activator activity
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0005515Molecular functionprotein binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_0140299Molecular functionsmall molecule sensor activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameNLRP3
Protein nameNLRP3
Cryopyrin, NACHT, LRR and PYD domains-containing protein 3
NACHT, LRR and PYD domains-containing protein 3 (EC 3.6.4.-) (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)
NACHT, LRR and PYD domains-containing protein 3
NLR family pyrin domain containing 3
SynonymsCIAS1
NALP3
PYPAF1
C1orf7
hCG_1982559
DescriptionFUNCTION: Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis . In response to pathogens and other damage-associated signals that affect the integrity of membranes, initiates the formation of the inflammasome polymeric complex composed of NLRP3, CASP1 and PYCARD/ASC . Recruitment of pro-caspase-1 (proCASP1) to the NLRP3 inflammasome promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), promoting cytokine secretion and pyroptosis . Activation of NLRP3 inflammasome is also required for HMGB1 secretion; stimulating inflammatory responses . Under resting conditions, ADP-bound NLRP3 is autoinhibited . NLRP3 activation stimuli include extracellular ATP, nigericin, reactive oxygen species, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, such as asbestos, silica, aluminum salts, cytosolic dsRNA, etc . Almost all stimuli trigger intracellular K(+) efflux (By similarity). These stimuli lead to membrane perturbation and activation of NLRP3 (By similarity). Upon activation, NLRP3 is transported to microtubule organizing center (MTOC), where it is unlocked by NEK7, leading to its relocalization to dispersed trans-Golgi network (dTGN) vesicle membranes and formation of an active inflammasome complex . Associates with dTGN vesicle membranes by binding to phosphatidylinositol 4-phosphate (PtdIns4P) . Shows ATPase activity . .; FUNCTION: Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription (By similarity). Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3' (By similarity). May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity). .

AccessionsENST00000474792.2
ENST00000642259.1
A0A7I2UNQ2
ENST00000391828.8
A0A7I2YME5
Q96P20
A0A7I2R3P8
A0A7I2PJH0
A0A7I2PRX0
A0A4Y5USH5
ENST00000348069.7
ENST00000366496.7
ENST00000391827.3
ENST00000643234.2
A0A7I2PMC6
ENST00000336119.8
ENST00000697350.1
A0A345Z977
A0A2R8YEG7