LOXL3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LOXL3 at tissue level.

III. Associated gene sets

GO_0001837Biological processepithelial to mesenchymal transition
GO_0030324Biological processlung development
GO_0006954Biological processinflammatory response
GO_0018057Biological processpeptidyl-lysine oxidation
GO_0021510Biological processspinal cord development
GO_0061053Biological processsomite development
GO_2001046Biological processpositive regulation of integrin-mediated signaling pathway
GO_1905590Biological processfibronectin fibril organization
GO_0060021Biological processroof of mouth development
GO_2000329Biological processnegative regulation of T-helper 17 cell lineage commitment
GO_0030199Biological processcollagen fibril organization
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0062023Cellular componentcollagen-containing extracellular matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004720Molecular functionprotein-lysine 6-oxidase activity
GO_0001968Molecular functionfibronectin binding
GO_0005507Molecular functioncopper ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLOXL3
Protein nameLysyl oxidase like 3
Uncharacterized protein LOXL3
Lysyl oxidase homolog (EC 1.4.3.13)
Lysyl oxidase homolog 3 (EC 1.4.3.-) (EC 1.4.3.13) (Lysyl oxidase-like protein 3)
Alternative protein LOXL3
SynonymsLOXL
DescriptionFUNCTION: Protein-lysine 6-oxidase that mediates the oxidation of peptidyl lysine residues to allysine in target proteins . Catalyzes the post-translational oxidative deamination of peptidyl lysine residues in precursors of elastin and different types of collagens, a prerequisite in the formation of cross-links between collagens and elastin . Required for somite boundary formation by catalyzing oxidation of fibronectin (FN1), enhancing integrin signaling in myofibers and their adhesion to the myotendinous junction (MTJ) (By similarity). Acts as a regulator of inflammatory response by inhibiting differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acts by interacting with STAT3 in the nucleus and catalyzing both deacetylation and oxidation of lysine residues on STAT3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity . Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated . Also able to catalyze deacetylation of lysine residues on STAT3 . .; FUNCTION: [Isoform 1]: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type VIII . .; FUNCTION: [Isoform 2]: Shows protein-lysine 6-oxidase activity toward elastin and different types of collagens, with the highest activity toward collagen type IV . .

FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). .

FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). .

FUNCTION: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). .

AccessionsC9J5M1
ENST00000409549.5
P58215
ENST00000409986.5
L8E911
ENST00000264094.8 [P58215-1]
H7C248
ENST00000409249.5
Q53TY1
B8ZZT6
E7END4
ENST00000413469.1
ENST00000393937.6 [P58215-3]
B9A025
ENST00000420535.1