NFATC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006954Biological processinflammatory response
GO_1905653Biological processpositive regulation of artery morphogenesis
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0001816Biological processcytokine production
GO_0033173Biological processcalcineurin-NFAT signaling cascade
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1905064Biological processnegative regulation of vascular associated smooth muscle cell differentiation
GO_0045429Biological processpositive regulation of nitric oxide biosynthetic process
GO_0006606Biological processprotein import into nucleus
GO_0045059Biological processpositive thymic T cell selection
GO_0043065Biological processpositive regulation of apoptotic process
GO_1904157Biological processDN4 thymocyte differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNFATC3
Protein nameNuclear factor of activated T-cells c3 isoform IAL-deltaXa (Nuclear factor of activated T-cells c3 isoform IAS-deltaXa) (Nuclear factor of activated T-cells c3 isoform IC-deltaXa) (Nuclear factor of activated T-cells c3 isoform ID-deltaXa) (Nuclear factor of activated T-cells c3 isoform IE-deltaXa) (Nuclear factor of activated T-cells c3 isoform IF-deltaXa)
Nuclear factor of activated T-cells c3 isoform IAL-IX (Nuclear factor of activated T-cells c3 isoform IAS-IX) (Nuclear factor of activated T-cells c3 isoform IC-IX) (Nuclear factor of activated T-cells c3 isoform ID-IX) (Nuclear factor of activated T-cells c3 isoform IE-IX) (Nuclear factor of activated T-cells c3 isoform IF-IX)
Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c)
Nuclear factor of activated T-cells c3 isoform IB-deltaXa (Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3, isoform CRA_b)
Nuclear factor of activated T-cells c3 isoform IB-Xa (Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3, isoform CRA_a)
Nuclear factor of activated T-cells c3 isoform IAL-Xa (Nuclear factor of activated T-cells c3 isoform IAS-Xa) (Nuclear factor of activated T-cells c3 isoform IC-Xa) (Nuclear factor of activated T-cells c3 isoform ID-Xa) (Nuclear factor of activated T-cells c3 isoform IE-Xa) (Nuclear factor of activated T-cells c3 isoform IF-Xa)
Nuclear factor of activated T cells 3
Nuclear factor of activated T-cells c3 isoform IB-IX
SynonymsNFAT4
hCG_28103
DescriptionFUNCTION: Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 . Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). .

AccessionsH3BRM3
ENST00000565750.2
I3L3K7
B5B2S5
ENST00000562171.1
ENST00000568466.6
B5B2S0
ENST00000562926.5
H3BRS1
ENST00000349223.9 [Q12968-3]
B5B2S3
H3BU30
ENST00000575270.5
ENST00000561714.5
Q12968
ENST00000329524.8 [Q12968-2]
ENST00000570212.5
B5B2S1
H3BR83
B5B2S2
ENST00000539828.6
B5B2S4
F8VPH9
ENST00000346183.8 [Q12968-1]