I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| basal cell | 8 studies | 27% ± 9% | |
| epithelial cell | 5 studies | 29% ± 17% | |
| keratinocyte | 4 studies | 47% ± 15% | |
| squamous epithelial cell | 3 studies | 41% ± 9% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| basal cell | 8 studies | 27% ± 9% | |
| epithelial cell | 5 studies | 29% ± 17% | |
| keratinocyte | 4 studies | 47% ± 15% | |
| squamous epithelial cell | 3 studies | 41% ± 9% |
Insufficient scRNA-seq data for expression of KRT16 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 41% | 22455.65 | 588 / 1445 | 64% | 1140.96 | 117 / 183 |
| tonsil | 0% | 0 | 0 / 0 | 93% | 3319.37 | 42 / 45 |
| skin | 75% | 14196.15 | 1351 / 1809 | 14% | 453.64 | 65 / 472 |
| uterus | 2% | 804.01 | 3 / 170 | 64% | 1597.97 | 293 / 459 |
| breast | 41% | 1140.51 | 187 / 459 | 16% | 83.02 | 181 / 1118 |
| blood vessel | 51% | 1287.55 | 683 / 1335 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 9.22 | 1 / 328 | 49% | 171.44 | 88 / 178 |
| lung | 0% | 2.16 | 1 / 578 | 40% | 429.01 | 460 / 1155 |
| bladder | 0% | 0 | 0 / 21 | 37% | 462.89 | 184 / 504 |
| prostate | 24% | 428.76 | 60 / 245 | 1% | 0.73 | 5 / 502 |
| adipose | 13% | 419.25 | 152 / 1204 | 0% | 0 | 0 / 0 |
| intestine | 0% | 0.67 | 1 / 966 | 7% | 62.94 | 39 / 527 |
| ovary | 1% | 2.89 | 1 / 180 | 4% | 2.92 | 18 / 430 |
| stomach | 1% | 13.18 | 5 / 359 | 3% | 6.92 | 8 / 286 |
| adrenal gland | 2% | 20.59 | 6 / 258 | 0% | 0.27 | 1 / 230 |
| thymus | 0% | 3.49 | 1 / 653 | 2% | 4.37 | 11 / 605 |
| liver | 0% | 0 | 0 / 226 | 1% | 1.85 | 3 / 406 |
| muscle | 1% | 9.74 | 5 / 803 | 0% | 0 | 0 / 0 |
| kidney | 0% | 0 | 0 / 89 | 0% | 1.93 | 3 / 901 |
| brain | 0% | 0.51 | 2 / 2642 | 0% | 0.07 | 1 / 705 |
| peripheral blood | 0% | 2.73 | 2 / 929 | 0% | 0 | 0 / 0 |
| heart | 0% | 1.06 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0030216 | Biological process | keratinocyte differentiation |
| GO_0006954 | Biological process | inflammatory response |
| GO_0002009 | Biological process | morphogenesis of an epithelium |
| GO_0061436 | Biological process | establishment of skin barrier |
| GO_0030855 | Biological process | epithelial cell differentiation |
| GO_0045087 | Biological process | innate immune response |
| GO_0031424 | Biological process | keratinization |
| GO_0051546 | Biological process | keratinocyte migration |
| GO_0007010 | Biological process | cytoskeleton organization |
| GO_0042633 | Biological process | hair cycle |
| GO_0045109 | Biological process | intermediate filament organization |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005882 | Cellular component | intermediate filament |
| GO_0001533 | Cellular component | cornified envelope |
| GO_0005829 | Cellular component | cytosol |
| GO_0045095 | Cellular component | keratin filament |
| GO_0005634 | Cellular component | nucleus |
| GO_0005200 | Molecular function | structural constituent of cytoskeleton |
| GO_0005515 | Molecular function | protein binding |
| Gene name | KRT16 |
| Protein name | Keratin 16 Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16) |
| Synonyms | KRT16A |
| Description | FUNCTION: Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance. . |
| Accessions | K7ENW6 ENST00000301653.9 ENST00000593067.1 P08779 ENST00000590990.1 K7ENV3 |
