KSR2 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	62% ± 27%	Explore
GABAergic neuron	10 studies	55% ± 29%	Explore
oligodendrocyte precursor cell	10 studies	32% ± 15%	Explore
interneuron	6 studies	58% ± 28%	Explore
neuron	5 studies	34% ± 10%	Explore
astrocyte	5 studies	32% ± 21%	Explore
granule cell	4 studies	51% ± 19%	Explore
amacrine cell	4 studies	27% ± 8%	Explore
GABAergic interneuron	3 studies	55% ± 10%	Explore
retinal bipolar neuron	3 studies	20% ± 5%	Explore
retina horizontal cell	3 studies	18% ± 2%	Explore
rod bipolar cell	3 studies	33% ± 12%	Explore

Name	Number of supported studies	Average coverage
brain	12 studies	43% ± 25%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	92%	445.96	600 / 653	61%	1.24	370 / 605
brain	93%	1970.84	2454 / 2642	57%	2.65	399 / 705
kidney	87%	365.24	77 / 89	14%	0.34	130 / 901
ureter	0%	0	0 / 0	100%	1.70	1 / 1
pancreas	81%	231.15	265 / 328	14%	0.49	25 / 178
adrenal gland	17%	112.00	44 / 258	45%	2.29	104 / 230
bladder	24%	63.57	5 / 21	17%	0.53	86 / 504
prostate	22%	58.33	55 / 245	16%	0.24	80 / 502
ovary	0%	0	0 / 180	38%	0.73	163 / 430
breast	9%	20.78	43 / 459	23%	0.42	252 / 1118
intestine	19%	44.51	185 / 966	6%	0.10	33 / 527
stomach	8%	20.91	30 / 359	7%	0.21	21 / 286
lung	4%	8.32	26 / 578	10%	0.22	118 / 1155
lymph node	0%	0	0 / 0	14%	0.26	4 / 29
esophagus	1%	1.26	8 / 1445	12%	0.25	22 / 183
uterus	1%	3.20	2 / 170	7%	0.12	31 / 459
liver	0%	0	0 / 226	2%	0.04	9 / 406
skin	1%	4.26	26 / 1809	1%	0.01	3 / 472
eye	0%	0	0 / 0	1%	0.01	1 / 80
peripheral blood	1%	1.72	6 / 929	0%	0	0 / 0
adipose	0%	1.02	3 / 1204	0%	0	0 / 0
heart	0%	0.77	2 / 861	0%	0	0 / 0
blood vessel	0%	0.28	1 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45

GO_0007265	Biological process	Ras protein signal transduction
GO_0120162	Biological process	positive regulation of cold-induced thermogenesis
GO_0019722	Biological process	calcium-mediated signaling
GO_0043410	Biological process	positive regulation of MAPK cascade
GO_0000165	Biological process	MAPK cascade
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0031434	Molecular function	mitogen-activated protein kinase kinase binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0005515	Molecular function	protein binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0005078	Molecular function	MAP-kinase scaffold activity
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0004672	Molecular function	protein kinase activity

Gene name	KSR2
Protein name	Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1)
Synonyms
Description	FUNCTION: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 . Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. .
Accessions	ENST00000339824.7 [Q6VAB6-1] Q6VAB6

KSR2 report