SH3RF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0016567Biological processprotein ubiquitination
GO_0000165Biological processMAPK cascade
GO_0046330Biological processpositive regulation of JNK cascade
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_2000564Biological processregulation of CD8-positive, alpha-beta T cell proliferation
GO_0051865Biological processprotein autoubiquitination
GO_0001764Biological processneuron migration
GO_0043066Biological processnegative regulation of apoptotic process
GO_1904044Biological processresponse to aldosterone
GO_0043370Biological processregulation of CD4-positive, alpha-beta T cell differentiation
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0030027Cellular componentlamellipodium
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005078Molecular functionMAP-kinase scaffold activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSH3RF1
Protein nameSH3 domain containing ring finger 1
E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2)
SynonymsSH3MD2
POSH
KIAA1494
RNF142
POSH1
DescriptionFUNCTION: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination . Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis . Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). .; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. .

AccessionsD6RAL3
ENST00000502315.1
ENST00000284637.14 [Q7Z6J0-1]
D6RHX5
ENST00000510806.1
H0YA90
Q7Z6J0
ENST00000511421.5