Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 16 studies | 29% ± 13% | |
astrocyte | 14 studies | 39% ± 17% | |
pericyte | 13 studies | 39% ± 17% | |
oligodendrocyte | 11 studies | 35% ± 12% | |
oligodendrocyte precursor cell | 10 studies | 33% ± 11% | |
type I pneumocyte | 8 studies | 47% ± 21% | |
epithelial cell | 8 studies | 37% ± 20% | |
adipocyte | 8 studies | 30% ± 9% | |
fibroblast | 8 studies | 32% ± 4% | |
ciliated cell | 8 studies | 31% ± 12% | |
macrophage | 7 studies | 30% ± 11% | |
microglial cell | 7 studies | 27% ± 12% | |
smooth muscle cell | 7 studies | 31% ± 12% | |
GABAergic neuron | 6 studies | 35% ± 16% | |
club cell | 6 studies | 39% ± 16% | |
type II pneumocyte | 5 studies | 44% ± 9% | |
cholangiocyte | 4 studies | 51% ± 22% | |
mesothelial cell | 4 studies | 30% ± 9% | |
basal cell | 4 studies | 36% ± 23% | |
luminal cell of prostate epithelium | 4 studies | 25% ± 5% | |
glutamatergic neuron | 4 studies | 51% ± 11% | |
interneuron | 4 studies | 30% ± 13% | |
hepatocyte | 3 studies | 50% ± 21% | |
connective tissue cell | 3 studies | 27% ± 5% | |
myeloid cell | 3 studies | 21% ± 3% | |
monocyte | 3 studies | 19% ± 1% | |
respiratory goblet cell | 3 studies | 40% ± 18% | |
goblet cell | 3 studies | 43% ± 37% | |
transit amplifying cell | 3 studies | 39% ± 31% | |
neuron | 3 studies | 38% ± 13% | |
renal principal cell | 3 studies | 44% ± 15% | |
mucus secreting cell | 3 studies | 37% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 2447.57 | 245 / 245 | 100% | 98.76 | 502 / 502 |
stomach | 100% | 1878.71 | 359 / 359 | 99% | 32.45 | 284 / 286 |
intestine | 100% | 1767.92 | 966 / 966 | 99% | 30.03 | 522 / 527 |
pancreas | 100% | 1041.33 | 328 / 328 | 99% | 37.56 | 176 / 178 |
breast | 100% | 2187.87 | 459 / 459 | 99% | 41.43 | 1102 / 1118 |
esophagus | 100% | 1030.18 | 1442 / 1445 | 98% | 32.47 | 180 / 183 |
lung | 100% | 1948.37 | 578 / 578 | 98% | 26.19 | 1128 / 1155 |
bladder | 100% | 1642.33 | 21 / 21 | 95% | 19.99 | 477 / 504 |
kidney | 100% | 1971.65 | 89 / 89 | 93% | 19.56 | 842 / 901 |
thymus | 100% | 2696.96 | 653 / 653 | 90% | 20.27 | 546 / 605 |
brain | 90% | 1523.86 | 2389 / 2642 | 98% | 21.23 | 691 / 705 |
ovary | 100% | 1974.60 | 180 / 180 | 88% | 16.98 | 379 / 430 |
uterus | 100% | 1015.54 | 170 / 170 | 87% | 15.86 | 398 / 459 |
adrenal gland | 97% | 655.12 | 251 / 258 | 83% | 14.74 | 190 / 230 |
skin | 100% | 1658.57 | 1804 / 1809 | 77% | 12.30 | 365 / 472 |
liver | 99% | 769.12 | 223 / 226 | 43% | 8.54 | 173 / 406 |
adipose | 100% | 2347.74 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2120.63 | 1335 / 1335 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.46 | 1 / 1 |
muscle | 100% | 1409.21 | 801 / 803 | 0% | 0 | 0 / 0 |
spleen | 97% | 577.19 | 234 / 241 | 0% | 0 | 0 / 0 |
heart | 96% | 935.70 | 830 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 76% | 12.15 | 34 / 45 |
eye | 0% | 0 | 0 / 0 | 51% | 5.57 | 41 / 80 |
lymph node | 0% | 0 | 0 / 0 | 31% | 4.45 | 9 / 29 |
peripheral blood | 20% | 450.75 | 184 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0043154 | Biological process | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
GO_0016567 | Biological process | protein ubiquitination |
GO_0000165 | Biological process | MAPK cascade |
GO_0046330 | Biological process | positive regulation of JNK cascade |
GO_0032436 | Biological process | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
GO_2000564 | Biological process | regulation of CD8-positive, alpha-beta T cell proliferation |
GO_0051865 | Biological process | protein autoubiquitination |
GO_0001764 | Biological process | neuron migration |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_1904044 | Biological process | response to aldosterone |
GO_0043370 | Biological process | regulation of CD4-positive, alpha-beta T cell differentiation |
GO_2001237 | Biological process | negative regulation of extrinsic apoptotic signaling pathway |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0030027 | Cellular component | lamellipodium |
GO_0061630 | Molecular function | ubiquitin protein ligase activity |
GO_0005078 | Molecular function | MAP-kinase scaffold activity |
GO_0046872 | Molecular function | metal ion binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SH3RF1 |
Protein name | SH3 domain containing ring finger 1 E3 ubiquitin-protein ligase SH3RF1 (EC 2.3.2.27) (Plenty of SH3s) (Protein POSH) (RING finger protein 142) (RING-type E3 ubiquitin transferase SH3RF1) (SH3 domain-containing RING finger protein 1) (SH3 multiple domains protein 2) |
Synonyms | SH3MD2 POSH KIAA1494 RNF142 POSH1 |
Description | FUNCTION: Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination . Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis . Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly (By similarity). .; FUNCTION: (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity. . |
Accessions | D6RAL3 ENST00000502315.1 ENST00000284637.14 [Q7Z6J0-1] D6RHX5 ENST00000510806.1 H0YA90 Q7Z6J0 ENST00000511421.5 |