POU4F2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of POU4F2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of POU4F2 at tissue level.

III. Associated gene sets

GO_2000679Biological processpositive regulation of transcription regulatory region DNA binding
GO_0007605Biological processsensory perception of sound
GO_0046326Biological processpositive regulation of glucose import
GO_0032869Biological processcellular response to insulin stimulus
GO_0090259Biological processregulation of retinal ganglion cell axon guidance
GO_0045773Biological processpositive regulation of axon extension
GO_0000165Biological processMAPK cascade
GO_0007507Biological processheart development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0071392Biological processcellular response to estradiol stimulus
GO_0050885Biological processneuromuscular process controlling balance
GO_0060041Biological processretina development in camera-type eye
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_1902870Biological processnegative regulation of amacrine cell differentiation
GO_0045672Biological processpositive regulation of osteoclast differentiation
GO_0030182Biological processneuron differentiation
GO_0045597Biological processpositive regulation of cell differentiation
GO_0071345Biological processcellular response to cytokine stimulus
GO_1904178Biological processnegative regulation of adipose tissue development
GO_0043068Biological processpositive regulation of programmed cell death
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_1990791Biological processdorsal root ganglion development
GO_0048675Biological processaxon extension
GO_0045596Biological processnegative regulation of cell differentiation
GO_0051090Biological processregulation of DNA-binding transcription factor activity
GO_0031290Biological processretinal ganglion cell axon guidance
GO_0030520Biological processestrogen receptor signaling pathway
GO_0007411Biological processaxon guidance
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016607Cellular componentnuclear speck
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0001227Molecular functionDNA-binding transcription repressor activity, RNA polymerase II-specific
GO_0002039Molecular functionp53 binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePOU4F2
Protein namePOU domain, class 4, transcription factor 2 (Brain-specific homeobox/POU domain protein 3B) (Brain-3B) (Brn-3B)
SynonymsBRN3B
DescriptionFUNCTION: Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells . Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner . Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation (By similarity). .

AccessionsQ12837
ENST00000281321.3 [Q12837-1]