MAPK7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of MAPK7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of MAPK7 at tissue level.

III. Associated gene sets

GO_2000352Biological processnegative regulation of endothelial cell apoptotic process
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0070885Biological processnegative regulation of calcineurin-NFAT signaling cascade
GO_0000165Biological processMAPK cascade
GO_0007165Biological processsignal transduction
GO_0033173Biological processcalcineurin-NFAT signaling cascade
GO_1902176Biological processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO_0071363Biological processcellular response to growth factor stimulus
GO_0034392Biological processnegative regulation of smooth muscle cell apoptotic process
GO_0045765Biological processregulation of angiogenesis
GO_0060761Biological processnegative regulation of response to cytokine stimulus
GO_0034115Biological processnegative regulation of heterotypic cell-cell adhesion
GO_0035556Biological processintracellular signal transduction
GO_0050728Biological processnegative regulation of inflammatory response
GO_0030154Biological processcell differentiation
GO_0007189Biological processadenylate cyclase-activating G protein-coupled receptor signaling pathway
GO_2001240Biological processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0071499Biological processcellular response to laminar fluid shear stress
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0004707Molecular functionMAP kinase activity
GO_0004857Molecular functionenzyme inhibitor activity
GO_0106310Molecular functionprotein serine kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0051019Molecular functionmitogen-activated protein kinase binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameMAPK7
Protein namemitogen-activated protein kinase (EC 2.7.11.24)
Mitogen-activated protein kinase 7
Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)
Mitogen-activated protein kinase (EC 2.7.11.24)
SynonymsBMK1
ERK5
PRKM7
DescriptionFUNCTION: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction. .

AccessionsENST00000603493.1
ENST00000579284.5
ENST00000482850.1
ENST00000299612.11 [Q13164-2]
ENST00000395604.8 [Q13164-1]
ENST00000443215.5
S4R3I1
J3KT61
ENST00000581260.5
Q13164
ENST00000308406.9 [Q13164-1]
J3KT50
ENST00000395602.8 [Q13164-1]
C9JUK9
I3L0J8