ZFP36L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045577Biological processregulation of B cell differentiation
GO_0010468Biological processregulation of gene expression
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0006397Biological processmRNA processing
GO_0008283Biological processcell population proliferation
GO_0032869Biological processcellular response to insulin stimulus
GO_0043488Biological processregulation of mRNA stability
GO_0051028Biological processmRNA transport
GO_0000165Biological processMAPK cascade
GO_0007507Biological processheart development
GO_0045647Biological processnegative regulation of erythrocyte differentiation
GO_0071364Biological processcellular response to epidermal growth factor stimulus
GO_0060710Biological processchorio-allantoic fusion
GO_0035264Biological processmulticellular organism growth
GO_0001570Biological processvasculogenesis
GO_0045657Biological processpositive regulation of monocyte differentiation
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_0045616Biological processregulation of keratinocyte differentiation
GO_0031086Biological processnuclear-transcribed mRNA catabolic process, deadenylation-independent decay
GO_0048382Biological processmesendoderm development
GO_0006417Biological processregulation of translation
GO_0097403Biological processcellular response to raffinose
GO_0033077Biological processT cell differentiation in thymus
GO_0071356Biological processcellular response to tumor necrosis factor
GO_1900153Biological processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0072091Biological processregulation of stem cell proliferation
GO_0071320Biological processcellular response to cAMP
GO_1904582Biological processpositive regulation of intracellular mRNA localization
GO_0070371Biological processERK1 and ERK2 cascade
GO_0071375Biological processcellular response to peptide hormone stimulus
GO_0045600Biological processpositive regulation of fat cell differentiation
GO_0071472Biological processcellular response to salt stress
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0003342Biological processproepicardium development
GO_0006915Biological processapoptotic process
GO_1901991Biological processnegative regulation of mitotic cell cycle phase transition
GO_0000288Biological processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0071385Biological processcellular response to glucocorticoid stimulus
GO_1902172Biological processregulation of keratinocyte apoptotic process
GO_0038066Biological processp38MAPK cascade
GO_0021915Biological processneural tube development
GO_0010837Biological processregulation of keratinocyte proliferation
GO_0045661Biological processregulation of myoblast differentiation
GO_0009611Biological processresponse to wounding
GO_0044344Biological processcellular response to fibroblast growth factor stimulus
GO_0071456Biological processcellular response to hypoxia
GO_0031440Biological processregulation of mRNA 3'-end processing
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0071889Molecular function14-3-3 protein binding
GO_0003729Molecular functionmRNA binding
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0046872Molecular functionmetal ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZFP36L1
Protein nameZFP36 ring finger protein like 1
mRNA decay activator protein ZFP36 (Zinc finger protein 36)
mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1)
SynonymsBRF1
RNF162B
ERF1
BERG36
TIS11B
DescriptionFUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis . Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery . Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes . Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs . Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress . Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA . Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA . Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA . In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) . In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells . Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion . Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis . Plays a role in myoblast cell differentiation (By similarity). .

FUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. .

FUNCTION: Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. .

AccessionsG3V515
G3V2D5
ENST00000557086.1
G3V2P5
Q07352
ENST00000336440.4
ENST00000557022.1
ENST00000553375.1
ENST00000439696.3