Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 27 studies | 31% ± 14% | |
fibroblast | 19 studies | 25% ± 10% | |
astrocyte | 15 studies | 43% ± 19% | |
oligodendrocyte | 15 studies | 63% ± 20% | |
oligodendrocyte precursor cell | 15 studies | 56% ± 21% | |
pericyte | 15 studies | 26% ± 12% | |
endothelial cell of lymphatic vessel | 12 studies | 34% ± 16% | |
microglial cell | 12 studies | 31% ± 13% | |
glutamatergic neuron | 10 studies | 49% ± 25% | |
smooth muscle cell | 10 studies | 27% ± 9% | |
GABAergic neuron | 9 studies | 48% ± 22% | |
mast cell | 8 studies | 24% ± 8% | |
epithelial cell | 8 studies | 33% ± 23% | |
adipocyte | 8 studies | 30% ± 9% | |
neuron | 7 studies | 42% ± 17% | |
retinal cone cell | 7 studies | 27% ± 10% | |
retina horizontal cell | 6 studies | 29% ± 12% | |
ciliated cell | 6 studies | 23% ± 6% | |
interneuron | 5 studies | 55% ± 18% | |
macrophage | 5 studies | 37% ± 10% | |
connective tissue cell | 5 studies | 20% ± 7% | |
capillary endothelial cell | 5 studies | 25% ± 9% | |
amacrine cell | 5 studies | 28% ± 13% | |
dendritic cell | 5 studies | 23% ± 6% | |
lymphocyte | 5 studies | 24% ± 9% | |
natural killer cell | 5 studies | 20% ± 4% | |
club cell | 5 studies | 24% ± 8% | |
myofibroblast cell | 5 studies | 26% ± 12% | |
type I pneumocyte | 5 studies | 23% ± 8% | |
basal cell | 5 studies | 34% ± 24% | |
glial cell | 4 studies | 39% ± 1% | |
granule cell | 4 studies | 37% ± 16% | |
retinal bipolar neuron | 4 studies | 27% ± 5% | |
Mueller cell | 4 studies | 25% ± 9% | |
erythrocyte | 4 studies | 43% ± 19% | |
glomerular endothelial cell | 3 studies | 21% ± 1% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 64% ± 6% | |
progenitor cell | 3 studies | 33% ± 2% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 19% ± 1% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 19% ± 3% | |
mesothelial cell | 3 studies | 26% ± 9% | |
vein endothelial cell | 3 studies | 35% ± 19% | |
myeloid cell | 3 studies | 20% ± 6% | |
GABAergic amacrine cell | 3 studies | 33% ± 10% | |
OFF-bipolar cell | 3 studies | 34% ± 12% | |
ON-bipolar cell | 3 studies | 33% ± 13% | |
glycinergic amacrine cell | 3 studies | 30% ± 5% | |
retinal ganglion cell | 3 studies | 35% ± 13% | |
retinal rod cell | 3 studies | 27% ± 6% | |
rod bipolar cell | 3 studies | 34% ± 15% | |
endothelial cell of vascular tree | 3 studies | 30% ± 16% | |
alveolar macrophage | 3 studies | 31% ± 9% | |
chondrocyte | 3 studies | 39% ± 16% | |
monocyte | 3 studies | 24% ± 3% | |
respiratory goblet cell | 3 studies | 30% ± 11% | |
gamma-delta T cell | 3 studies | 19% ± 1% | |
Schwann cell | 3 studies | 41% ± 25% | |
transit amplifying cell | 3 studies | 40% ± 34% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3520.91 | 1445 / 1445 | 100% | 24.82 | 183 / 183 |
lung | 100% | 3947.51 | 578 / 578 | 100% | 19.86 | 1152 / 1155 |
breast | 100% | 4124.86 | 459 / 459 | 100% | 24.80 | 1115 / 1118 |
brain | 100% | 3088.54 | 2640 / 2642 | 100% | 27.28 | 703 / 705 |
prostate | 100% | 3649.89 | 245 / 245 | 100% | 16.80 | 500 / 502 |
uterus | 100% | 6312.90 | 170 / 170 | 99% | 21.58 | 453 / 459 |
bladder | 100% | 4142.19 | 21 / 21 | 99% | 17.83 | 497 / 504 |
thymus | 100% | 3296.88 | 653 / 653 | 99% | 16.86 | 596 / 605 |
ovary | 100% | 5315.07 | 180 / 180 | 98% | 11.92 | 421 / 430 |
pancreas | 99% | 1732.70 | 324 / 328 | 98% | 21.69 | 175 / 178 |
stomach | 100% | 2292.51 | 359 / 359 | 97% | 14.51 | 277 / 286 |
intestine | 100% | 3651.68 | 966 / 966 | 96% | 14.98 | 507 / 527 |
kidney | 100% | 1900.36 | 89 / 89 | 96% | 14.35 | 861 / 901 |
skin | 100% | 5307.12 | 1809 / 1809 | 94% | 17.74 | 442 / 472 |
adrenal gland | 100% | 2014.68 | 258 / 258 | 93% | 11.91 | 215 / 230 |
liver | 77% | 708.20 | 173 / 226 | 65% | 5.96 | 263 / 406 |
blood vessel | 100% | 3744.06 | 1335 / 1335 | 0% | 0 | 0 / 0 |
spleen | 100% | 2526.34 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 9.24 | 1 / 1 |
adipose | 100% | 3898.24 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 99% | 1482.81 | 796 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 16.81 | 44 / 45 |
heart | 94% | 1413.96 | 812 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 90% | 10.45 | 26 / 29 |
eye | 0% | 0 | 0 / 0 | 79% | 8.35 | 63 / 80 |
peripheral blood | 32% | 626.38 | 295 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0035556 | Biological process | intracellular signal transduction |
GO_0006468 | Biological process | protein phosphorylation |
GO_0000165 | Biological process | MAPK cascade |
GO_0005829 | Cellular component | cytosol |
GO_0005886 | Cellular component | plasma membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0004674 | Molecular function | protein serine/threonine kinase activity |
GO_0106310 | Molecular function | protein serine kinase activity |
GO_0005515 | Molecular function | protein binding |
GO_0008349 | Molecular function | MAP kinase kinase kinase kinase activity |
GO_0005524 | Molecular function | ATP binding |
GO_0004672 | Molecular function | protein kinase activity |
Gene name | MAP4K5 |
Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) Mitogen-activated protein kinase kinase kinase kinase 5 |
Synonyms | |
Description | FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. . FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. . FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. . |
Accessions | ENST00000554091.5 ENST00000013125.9 A0A804HIS2 G3V4Q4 G3V4T8 G3V5C6 ENST00000555216.5 ENST00000682126.1 ENST00000557390.6 Q9Y4K4 |