Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 27 studies | 31% ± 14% | |
| fibroblast | 19 studies | 25% ± 10% | |
| astrocyte | 15 studies | 43% ± 19% | |
| oligodendrocyte | 15 studies | 63% ± 20% | |
| oligodendrocyte precursor cell | 15 studies | 56% ± 21% | |
| pericyte | 15 studies | 26% ± 12% | |
| endothelial cell of lymphatic vessel | 12 studies | 34% ± 16% | |
| microglial cell | 12 studies | 31% ± 13% | |
| glutamatergic neuron | 10 studies | 49% ± 25% | |
| smooth muscle cell | 10 studies | 27% ± 9% | |
| GABAergic neuron | 9 studies | 48% ± 22% | |
| mast cell | 8 studies | 24% ± 8% | |
| epithelial cell | 8 studies | 33% ± 23% | |
| adipocyte | 8 studies | 30% ± 9% | |
| neuron | 7 studies | 42% ± 17% | |
| retinal cone cell | 7 studies | 27% ± 10% | |
| retina horizontal cell | 6 studies | 29% ± 12% | |
| ciliated cell | 6 studies | 23% ± 6% | |
| interneuron | 5 studies | 55% ± 18% | |
| macrophage | 5 studies | 37% ± 10% | |
| connective tissue cell | 5 studies | 20% ± 7% | |
| capillary endothelial cell | 5 studies | 25% ± 9% | |
| amacrine cell | 5 studies | 28% ± 13% | |
| dendritic cell | 5 studies | 23% ± 6% | |
| lymphocyte | 5 studies | 24% ± 9% | |
| natural killer cell | 5 studies | 20% ± 4% | |
| club cell | 5 studies | 24% ± 8% | |
| myofibroblast cell | 5 studies | 26% ± 12% | |
| type I pneumocyte | 5 studies | 23% ± 8% | |
| basal cell | 5 studies | 34% ± 24% | |
| glial cell | 4 studies | 39% ± 1% | |
| granule cell | 4 studies | 37% ± 16% | |
| retinal bipolar neuron | 4 studies | 27% ± 5% | |
| Mueller cell | 4 studies | 25% ± 9% | |
| erythrocyte | 4 studies | 43% ± 19% | |
| glomerular endothelial cell | 3 studies | 21% ± 1% | |
| differentiation-committed oligodendrocyte precursor | 3 studies | 64% ± 6% | |
| progenitor cell | 3 studies | 33% ± 2% | |
| CD16-negative, CD56-bright natural killer cell, human | 3 studies | 19% ± 1% | |
| CD16-positive, CD56-dim natural killer cell, human | 3 studies | 19% ± 3% | |
| mesothelial cell | 3 studies | 26% ± 9% | |
| vein endothelial cell | 3 studies | 35% ± 19% | |
| myeloid cell | 3 studies | 20% ± 6% | |
| GABAergic amacrine cell | 3 studies | 33% ± 10% | |
| OFF-bipolar cell | 3 studies | 34% ± 12% | |
| ON-bipolar cell | 3 studies | 33% ± 13% | |
| glycinergic amacrine cell | 3 studies | 30% ± 5% | |
| retinal ganglion cell | 3 studies | 35% ± 13% | |
| retinal rod cell | 3 studies | 27% ± 6% | |
| rod bipolar cell | 3 studies | 34% ± 15% | |
| endothelial cell of vascular tree | 3 studies | 30% ± 16% | |
| alveolar macrophage | 3 studies | 31% ± 9% | |
| chondrocyte | 3 studies | 39% ± 16% | |
| monocyte | 3 studies | 24% ± 3% | |
| respiratory goblet cell | 3 studies | 30% ± 11% | |
| gamma-delta T cell | 3 studies | 19% ± 1% | |
| Schwann cell | 3 studies | 41% ± 25% | |
| transit amplifying cell | 3 studies | 40% ± 34% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 3520.91 | 1445 / 1445 | 100% | 24.82 | 183 / 183 |
| lung | 100% | 3947.51 | 578 / 578 | 100% | 19.86 | 1152 / 1155 |
| breast | 100% | 4124.86 | 459 / 459 | 100% | 24.80 | 1115 / 1118 |
| brain | 100% | 3088.54 | 2640 / 2642 | 100% | 27.28 | 703 / 705 |
| prostate | 100% | 3649.89 | 245 / 245 | 100% | 16.80 | 500 / 502 |
| uterus | 100% | 6312.90 | 170 / 170 | 99% | 21.58 | 453 / 459 |
| bladder | 100% | 4142.19 | 21 / 21 | 99% | 17.83 | 497 / 504 |
| thymus | 100% | 3296.88 | 653 / 653 | 99% | 16.86 | 596 / 605 |
| ovary | 100% | 5315.07 | 180 / 180 | 98% | 11.92 | 421 / 430 |
| pancreas | 99% | 1732.70 | 324 / 328 | 98% | 21.69 | 175 / 178 |
| stomach | 100% | 2292.51 | 359 / 359 | 97% | 14.51 | 277 / 286 |
| intestine | 100% | 3651.68 | 966 / 966 | 96% | 14.98 | 507 / 527 |
| kidney | 100% | 1900.36 | 89 / 89 | 96% | 14.35 | 861 / 901 |
| skin | 100% | 5307.12 | 1809 / 1809 | 94% | 17.74 | 442 / 472 |
| adrenal gland | 100% | 2014.68 | 258 / 258 | 93% | 11.91 | 215 / 230 |
| liver | 77% | 708.20 | 173 / 226 | 65% | 5.96 | 263 / 406 |
| blood vessel | 100% | 3744.06 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2526.34 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.24 | 1 / 1 |
| adipose | 100% | 3898.24 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1482.81 | 796 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 16.81 | 44 / 45 |
| heart | 94% | 1413.96 | 812 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 10.45 | 26 / 29 |
| eye | 0% | 0 | 0 / 0 | 79% | 8.35 | 63 / 80 |
| peripheral blood | 32% | 626.38 | 295 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0000165 | Biological process | MAPK cascade |
| GO_0005829 | Cellular component | cytosol |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0008349 | Molecular function | MAP kinase kinase kinase kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0004672 | Molecular function | protein kinase activity |
| Gene name | MAP4K5 |
| Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5) Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) Mitogen-activated protein kinase kinase kinase kinase 5 |
| Synonyms | |
| Description | FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. . FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. . FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. . |
| Accessions | ENST00000554091.5 ENST00000013125.9 A0A804HIS2 G3V4Q4 G3V4T8 G3V5C6 ENST00000555216.5 ENST00000682126.1 ENST00000557390.6 Q9Y4K4 |