MAP3K2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	26 studies	29% ± 13%	Explore
endothelial cell	22 studies	29% ± 13%	Explore
classical monocyte	19 studies	30% ± 11%	Explore
fibroblast	17 studies	24% ± 9%	Explore
plasmacytoid dendritic cell	15 studies	32% ± 11%	Explore
B cell	14 studies	25% ± 8%	Explore
astrocyte	14 studies	30% ± 16%	Explore
monocyte	13 studies	28% ± 10%	Explore
oligodendrocyte	13 studies	33% ± 12%	Explore
conventional dendritic cell	13 studies	23% ± 10%	Explore
microglial cell	12 studies	40% ± 16%	Explore
dendritic cell	11 studies	34% ± 17%	Explore
non-classical monocyte	11 studies	28% ± 14%	Explore
ciliated cell	10 studies	27% ± 12%	Explore
glutamatergic neuron	10 studies	40% ± 23%	Explore
oligodendrocyte precursor cell	10 studies	30% ± 14%	Explore
myeloid cell	10 studies	31% ± 10%	Explore
smooth muscle cell	9 studies	21% ± 4%	Explore
type I pneumocyte	9 studies	24% ± 9%	Explore
pericyte	9 studies	23% ± 9%	Explore
mast cell	8 studies	21% ± 6%	Explore
neutrophil	8 studies	24% ± 8%	Explore
naive B cell	8 studies	22% ± 6%	Explore
GABAergic neuron	8 studies	39% ± 19%	Explore
epithelial cell	8 studies	37% ± 20%	Explore
adipocyte	8 studies	29% ± 6%	Explore
T cell	7 studies	25% ± 6%	Explore
natural killer cell	7 studies	22% ± 3%	Explore
mononuclear phagocyte	7 studies	22% ± 5%	Explore
basal cell	7 studies	27% ± 15%	Explore
retinal cone cell	7 studies	24% ± 9%	Explore
endothelial cell of lymphatic vessel	6 studies	29% ± 10%	Explore
leukocyte	6 studies	27% ± 8%	Explore
CD4-positive, alpha-beta T cell	6 studies	19% ± 4%	Explore
neuron	6 studies	40% ± 21%	Explore
interneuron	6 studies	40% ± 23%	Explore
club cell	6 studies	24% ± 8%	Explore
type II pneumocyte	6 studies	22% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	22% ± 4%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	19% ± 3%	Explore
CD8-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	23% ± 5%	Explore
memory B cell	5 studies	22% ± 7%	Explore
amacrine cell	5 studies	21% ± 6%	Explore
retina horizontal cell	5 studies	20% ± 6%	Explore
alveolar macrophage	5 studies	33% ± 18%	Explore
CD16-negative, CD56-bright natural killer cell, human	4 studies	19% ± 1%	Explore
mature NK T cell	4 studies	22% ± 6%	Explore
granule cell	4 studies	28% ± 8%	Explore
retinal pigment epithelial cell	4 studies	37% ± 19%	Explore
cardiac muscle cell	4 studies	23% ± 2%	Explore
lymphocyte	4 studies	31% ± 10%	Explore
retinal rod cell	4 studies	26% ± 6%	Explore
respiratory goblet cell	4 studies	27% ± 14%	Explore
regulatory T cell	4 studies	20% ± 4%	Explore
connective tissue cell	4 studies	20% ± 3%	Explore
goblet cell	4 studies	29% ± 18%	Explore
myofibroblast cell	4 studies	24% ± 9%	Explore
hematopoietic precursor cell	3 studies	26% ± 6%	Explore
GABAergic interneuron	3 studies	26% ± 4%	Explore
glial cell	3 studies	18% ± 2%	Explore
retinal ganglion cell	3 studies	23% ± 6%	Explore
plasma cell	3 studies	30% ± 7%	Explore
mesothelial cell	3 studies	25% ± 6%	Explore
tissue-resident macrophage	3 studies	24% ± 5%	Explore
retinal bipolar neuron	3 studies	16% ± 1%	Explore
GABAergic amacrine cell	3 studies	23% ± 8%	Explore
Mueller cell	3 studies	24% ± 11%	Explore
OFF-bipolar cell	3 studies	20% ± 6%	Explore
ON-bipolar cell	3 studies	19% ± 5%	Explore
glycinergic amacrine cell	3 studies	21% ± 3%	Explore
rod bipolar cell	3 studies	21% ± 7%	Explore
gamma-delta T cell	3 studies	30% ± 3%	Explore
endothelial cell of vascular tree	3 studies	29% ± 15%	Explore
hepatocyte	3 studies	54% ± 15%	Explore
pancreatic A cell	3 studies	41% ± 13%	Explore
ependymal cell	3 studies	32% ± 15%	Explore
enteroendocrine cell	3 studies	22% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	16 studies	34% ± 18%	Explore
lung	9 studies	24% ± 8%	Explore
peripheral blood	5 studies	31% ± 8%	Explore
eye	5 studies	30% ± 16%	Explore
heart	4 studies	20% ± 4%	Explore
liver	4 studies	31% ± 17%	Explore
intestine	3 studies	18% ± 1%	Explore
adipose	3 studies	28% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3295.92	1445 / 1445	100%	30.26	183 / 183
lung	100%	4933.04	578 / 578	100%	21.85	1155 / 1155
breast	100%	4166.51	459 / 459	100%	24.92	1115 / 1118
ovary	100%	4378.85	180 / 180	100%	12.90	428 / 430
thymus	100%	4813.61	653 / 653	99%	22.52	601 / 605
brain	99%	2172.76	2616 / 2642	100%	15.73	705 / 705
uterus	100%	4594.93	170 / 170	99%	17.83	454 / 459
prostate	100%	3425.10	245 / 245	99%	15.77	496 / 502
bladder	100%	3921.67	21 / 21	98%	15.54	495 / 504
pancreas	100%	2106.43	327 / 328	98%	20.39	175 / 178
kidney	100%	2576.29	89 / 89	98%	19.81	883 / 901
stomach	100%	2837.16	359 / 359	98%	18.68	279 / 286
intestine	100%	4058.94	966 / 966	97%	15.54	510 / 527
adrenal gland	100%	3148.98	258 / 258	95%	12.59	219 / 230
liver	100%	2863.97	226 / 226	95%	11.03	386 / 406
skin	100%	4693.01	1809 / 1809	90%	14.14	423 / 472
adipose	100%	4410.88	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4801.65	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	13.05	29 / 29
spleen	100%	4195.58	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.14	45 / 45
ureter	0%	0	0 / 0	100%	4.55	1 / 1
muscle	100%	3413.40	802 / 803	0%	0	0 / 0
peripheral blood	99%	5281.75	920 / 929	0%	0	0 / 0
heart	97%	1949.45	837 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	59%	6.04	47 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0035556	Biological process	intracellular signal transduction
GO_0071260	Biological process	cellular response to mechanical stimulus
GO_0000165	Biological process	MAPK cascade
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0004709	Molecular function	MAP kinase kinase kinase activity
GO_0019901	Molecular function	protein kinase binding
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0106310	Molecular function	protein serine kinase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding
GO_0005524	Molecular function	ATP binding
GO_0004672	Molecular function	protein kinase activity

IV. Literature review

[source]

Gene name	MAP3K2
Protein name	MAP3K2 protein Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
Synonyms	MEKK2 MAPKKK2
Description	FUNCTION: Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics. .
Accessions	Q6P084 ENST00000682094.1 ENST00000344908.9 Q9Y2U5 ENST00000409947.5

MAP3K2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review